Abstract

Background: Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. Objective: This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. Methods: A total of 564 first, fourth and seventh graders (314 children with overweight/obesity and 250 children with normal weight) completed an in-hospital health examination in 2010. All students received a physical examination, underwent blood sample collection and completed a questionnaire. Multiple linear regression analyses were performed for analyses. Results: Among the fourth and seventh graders (P=.003 and.001, respectively), the students with overweight/obesity displayed significantly higher levels of NO than those with normal weight; however, no difference was observed in males and females. In multiple linear regression models, a high level of anxiety was independently associated with low NO levels (β=−1.33, 95% confidence interval −2.24 to −0.41) in first graders who with overweight/obesity. No association between NO levels and psychological traits was evident among students with normal weight. Conclusions: Our results enrich the limited data and suggest that NO may be associated with obesity and psychopathology and should be a concern in the pathophysiology of childhood mental health and obesity.

Original languageEnglish
JournalPediatric obesity
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Taiwan
Nitric Oxide
Obesity
Psychology
Linear Models
Pediatric Obesity
Students
Weights and Measures
Anxiety
Anger
Psychopathology
Self Concept
Physical Examination
Mental Health
Regression Analysis
Confidence Intervals
Depression
Health

Keywords

  • anxiety
  • children
  • nitric oxide (NO)
  • obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Health Policy
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

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title = "Associations of nitric oxide with obesity and psychological traits among children and adolescents in Taiwan",
abstract = "Background: Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. Objective: This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. Methods: A total of 564 first, fourth and seventh graders (314 children with overweight/obesity and 250 children with normal weight) completed an in-hospital health examination in 2010. All students received a physical examination, underwent blood sample collection and completed a questionnaire. Multiple linear regression analyses were performed for analyses. Results: Among the fourth and seventh graders (P=.003 and.001, respectively), the students with overweight/obesity displayed significantly higher levels of NO than those with normal weight; however, no difference was observed in males and females. In multiple linear regression models, a high level of anxiety was independently associated with low NO levels (β=−1.33, 95{\%} confidence interval −2.24 to −0.41) in first graders who with overweight/obesity. No association between NO levels and psychological traits was evident among students with normal weight. Conclusions: Our results enrich the limited data and suggest that NO may be associated with obesity and psychopathology and should be a concern in the pathophysiology of childhood mental health and obesity.",
keywords = "anxiety, children, nitric oxide (NO), obesity",
author = "Chung, {Kuo Hsuan} and Chiou, {Hung Yi} and Chang, {Jung Su} and Chen, {Yi Hua}",
year = "2019",
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doi = "10.1111/ijpo.12593",
language = "English",
journal = "Pediatric obesity",
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AU - Chung, Kuo Hsuan

AU - Chiou, Hung Yi

AU - Chang, Jung Su

AU - Chen, Yi Hua

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N2 - Background: Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. Objective: This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. Methods: A total of 564 first, fourth and seventh graders (314 children with overweight/obesity and 250 children with normal weight) completed an in-hospital health examination in 2010. All students received a physical examination, underwent blood sample collection and completed a questionnaire. Multiple linear regression analyses were performed for analyses. Results: Among the fourth and seventh graders (P=.003 and.001, respectively), the students with overweight/obesity displayed significantly higher levels of NO than those with normal weight; however, no difference was observed in males and females. In multiple linear regression models, a high level of anxiety was independently associated with low NO levels (β=−1.33, 95% confidence interval −2.24 to −0.41) in first graders who with overweight/obesity. No association between NO levels and psychological traits was evident among students with normal weight. Conclusions: Our results enrich the limited data and suggest that NO may be associated with obesity and psychopathology and should be a concern in the pathophysiology of childhood mental health and obesity.

AB - Background: Findings concerning nitric oxide (NO) in children and adolescents with obesity are scant. Objective: This study examined the links of NO with obesity and psychological traits (ie, self-concept, anxiety, depression, anger and disruptive behaviour) in children and adolescents in Taiwan. Methods: A total of 564 first, fourth and seventh graders (314 children with overweight/obesity and 250 children with normal weight) completed an in-hospital health examination in 2010. All students received a physical examination, underwent blood sample collection and completed a questionnaire. Multiple linear regression analyses were performed for analyses. Results: Among the fourth and seventh graders (P=.003 and.001, respectively), the students with overweight/obesity displayed significantly higher levels of NO than those with normal weight; however, no difference was observed in males and females. In multiple linear regression models, a high level of anxiety was independently associated with low NO levels (β=−1.33, 95% confidence interval −2.24 to −0.41) in first graders who with overweight/obesity. No association between NO levels and psychological traits was evident among students with normal weight. Conclusions: Our results enrich the limited data and suggest that NO may be associated with obesity and psychopathology and should be a concern in the pathophysiology of childhood mental health and obesity.

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