Abstract

Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

Original languageEnglish
Article number291
JournalBMC Nephrology
Volume18
Issue number1
DOIs
Publication statusPublished - Sep 7 2017

Fingerprint

Endothelins
Renal Insufficiency
Chronic Kidney Failure
Genes
Tibial Arteries
Quantitative Trait Loci
Vasoconstrictor Agents
Single Nucleotide Polymorphism
Blood Vessels
Cause of Death
Hospitalization
Homeostasis
Biomarkers
Gene Expression

Keywords

  • Cardiovascular
  • Endothelin
  • Renal failure

ASJC Scopus subject areas

  • Nephrology

Cite this

Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure. / Kao, Chih Chin; Cheng, Shih Ying; Wu, Mei Yi; Chien, Shu Chen; Lu, Hsing Fang; Hsu, Yu Wen; Zhang, Yan Feng; Wu, Mai Szu; Chang, Wei Chiao.

In: BMC Nephrology, Vol. 18, No. 1, 291, 07.09.2017.

Research output: Contribution to journalArticle

@article{ae5cf5f4355b44049f80f1c290e31571,
title = "Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure",
abstract = "Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62{\%} (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.",
keywords = "Cardiovascular, Endothelin, Renal failure",
author = "Kao, {Chih Chin} and Cheng, {Shih Ying} and Wu, {Mei Yi} and Chien, {Shu Chen} and Lu, {Hsing Fang} and Hsu, {Yu Wen} and Zhang, {Yan Feng} and Wu, {Mai Szu} and Chang, {Wei Chiao}",
year = "2017",
month = "9",
day = "7",
doi = "10.1186/s12882-017-0707-2",
language = "English",
volume = "18",
journal = "BMC Nephrology",
issn = "1471-2369",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure

AU - Kao, Chih Chin

AU - Cheng, Shih Ying

AU - Wu, Mei Yi

AU - Chien, Shu Chen

AU - Lu, Hsing Fang

AU - Hsu, Yu Wen

AU - Zhang, Yan Feng

AU - Wu, Mai Szu

AU - Chang, Wei Chiao

PY - 2017/9/7

Y1 - 2017/9/7

N2 - Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

AB - Background: Cardiovascular (CV) complications are the main cause of death in end-stage renal disease (ESRD) patients. The high CV risks are attributable to the additive effects of multiple factors. Endothelin (EDN) is a potent vasoconstrictor and plays a role in regulating vascular homeostasis. However, whether variants of the EDN gene are associated with risks of CV events is not known. We conducted a study to investigate associations of variants of the EDN gene with CV events in ESRD patients. Methods: A cohort of 190 ESRD patients was recruited, and 19 tagged single-nucleotide polymorphisms within the EDN gene family were selected for genotyping through a TaqMan assay. Data on clinical characteristics and hospitalizations for CV events were collected. Associations of genetic variants of the EDN gene with CV events were analyzed. Results: In this cohort, 62% (n = 118) of patients were hospitalized for a CV event. The EDN1 rs4714384 (CC/TC vs. TT) polymorphism was associated with an increased risk of a CV event after multiple testing (p < 0.001). Further functional exploration showed that it was a quantitative trait locus which may significantly alter gene expression in the tibial artery. Conclusions: EDN1 rs4714384 is very likely an important biomarker of CV events in ESRD patients.

KW - Cardiovascular

KW - Endothelin

KW - Renal failure

UR - http://www.scopus.com/inward/record.url?scp=85028958941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028958941&partnerID=8YFLogxK

U2 - 10.1186/s12882-017-0707-2

DO - 10.1186/s12882-017-0707-2

M3 - Article

VL - 18

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

IS - 1

M1 - 291

ER -