Associations of gene polymorphisms in interferon-alpha signature-related genes with autoimmune thyroid diseases

Jiunn Diann Lin, Shun Fa Yang, Yuan Hung Wang, Wen Fang Fang, Kam Tsun Tang, Chao Wen Cheng

Research output: Contribution to journalArticle

Abstract

Summary: Interferon (IFN)-α treatment predisposes patients to the occurrence of autoimmune thyroid disease (AITD). Methods: We investigated associations of single nucleotide polymorphisms (SNPs) of molecules participating in the IFN-α signature, including rs2304204 and rs2304206 of IFN regulatory factor 3 (IRF3), rs1061501 of IRF7, and rs7708392 of TNFA1P3-interacting protein 1 with serum IFN-α levels and AITD in an ethnic Chinese (ie Taiwanese) population. Totally, 319 patients with Graves' disease (GD), 83 patients with Hashimoto's thyroiditis (HT) and 351 healthy controls were recruited. Results: There were increased percentages of the C allele, and CC and TC + CC genotypes of rs1061501 in GD patients compared to the controls. HT patients had higher serum IFN-α levels compared to the controls, while there was no difference in serum IFN-α levels between patients with GD and controls. However, patients with GD in a remission status had lower serum IFN-α levels than those without remission. On the other hand, the C allele of rs1061501 was only associated with serum IFN-α levels in patients with HT. Conclusions: The SNP rs1061501 of IRF7 was associated with the development of GD. Serum IFN-α levels were associated with HT, while they might modify the disease status of GD. Moreover, a genetic effect of rs1061501 on regulating serum IFN-α production was observed in HT.

Original languageEnglish
Pages (from-to)860-868
Number of pages9
JournalClinical Endocrinology
Volume91
Issue number6
DOIs
Publication statusPublished - Dec 1 2019

Keywords

  • autoimmune thyroid disease
  • Graves' disease
  • Hashimoto's thyroiditis
  • interferon regulatory factor 3
  • interferon regulatory factor 7

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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