TY - JOUR
T1 - Associations between personal exposure to metals in fine particulate matter and autonomic nervous system dysfunction among healthy adults
AU - Liao, Yi Hsueh
AU - Chen, Wei Liang
AU - Wang, Chung Ching
AU - Lai, Ching Huang
N1 - Funding Information:
This study was supported by grants (NSC102-EPA-F-003-001 and 103-2314-B-016-007) from the Environmental Protection Administration and National Science Council of Taiwan, Republic of China and the Ministry of Science and Technology.
Publisher Copyright:
© The Author(s).
PY - 2020/8
Y1 - 2020/8
N2 - The impact of airborne particulate matter and its metal components on autonomic nervous system (ANS) dysfunction in healthy subjects remains unclear. The aim of this study was to examine the effects of personal exposure to airborne particulate matter on the ANS in young, healthy adults. This longitudinal study recruited 82 adults aged 20 to 35 years from districts A and B. District A had lower ambient PM2.5 levels than district B. Personal exposure to fine particulate matter and metals in PM2.5 was collected every two months. The heart rate variability (HRV) indices of each participant were measured three times. The relationship among the PM2.5 concentration, metals in PM2.5 and HRV level was investigated by a generalized estimating equation with an autoregression of order 1. The average age of the participants was 26.4 ± 3.6 years in district A and 21.9 ± 1.5 years in district B (p < 0.001). After adjusting for covariables, significant changes in Log10 standard deviation of normal to normal (SDNN) intervals and Log10 square root of the mean of the sum of the squares of differences (r-MSSDs) were related to unit changes in Log10 iron in PM2.5 (β = –0.033, 95% CI = –0.060 to –0.0056, p < 0.05 and β = –0.041, 95% CI = –0.075 to –0.0076, p < 0.05, respectively). The Log10 SDNN levels were significantly positively related to Log10 gallium in PM2.5 (β = 0.054, 95% CI = 0.0064 to 0.10, p < 0.05). Exposure to heavy metals in airborne particulate matter was associated with ANS dysfunction.
AB - The impact of airborne particulate matter and its metal components on autonomic nervous system (ANS) dysfunction in healthy subjects remains unclear. The aim of this study was to examine the effects of personal exposure to airborne particulate matter on the ANS in young, healthy adults. This longitudinal study recruited 82 adults aged 20 to 35 years from districts A and B. District A had lower ambient PM2.5 levels than district B. Personal exposure to fine particulate matter and metals in PM2.5 was collected every two months. The heart rate variability (HRV) indices of each participant were measured three times. The relationship among the PM2.5 concentration, metals in PM2.5 and HRV level was investigated by a generalized estimating equation with an autoregression of order 1. The average age of the participants was 26.4 ± 3.6 years in district A and 21.9 ± 1.5 years in district B (p < 0.001). After adjusting for covariables, significant changes in Log10 standard deviation of normal to normal (SDNN) intervals and Log10 square root of the mean of the sum of the squares of differences (r-MSSDs) were related to unit changes in Log10 iron in PM2.5 (β = –0.033, 95% CI = –0.060 to –0.0056, p < 0.05 and β = –0.041, 95% CI = –0.075 to –0.0076, p < 0.05, respectively). The Log10 SDNN levels were significantly positively related to Log10 gallium in PM2.5 (β = 0.054, 95% CI = 0.0064 to 0.10, p < 0.05). Exposure to heavy metals in airborne particulate matter was associated with ANS dysfunction.
KW - Autonomic nervous system
KW - Metals
KW - Particulate matter
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U2 - 10.4209/aaqr.2020.04.0156
DO - 10.4209/aaqr.2020.04.0156
M3 - Article
AN - SCOPUS:85088924155
SN - 1680-8584
VL - 20
SP - 1842
EP - 1849
JO - Aerosol and Air Quality Research
JF - Aerosol and Air Quality Research
IS - 8
ER -