@article{edb96feb471a469abc018cd213acbfb5,
title = "Associations between MTHFR polymorphisms and the risk of potentially malignant oral disorders",
abstract = "Aim: The study aimed to investigate the role of two polymorphisms of methylenetetrahydrofolate reductase (MTHFR), C677T and A1298C, in the risk of potentially malignant oral disorders (PMODs). Materials and Methods: Genotypes of the MTHFR C677T and A1298C polymorphisms were determined using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) for 224 PMOD cases and 485 age-matched controls. Results: The C677T T allele-carrying genotypes were significantly associated with a decreased risk of PMODs [odds ratio (OR)=0.62, 95% confidence interval (CI)=0.44-0.86]. Haplotype analysis also indicated that the 677T/1298A haplotype was associated with a decreased risk of PMODs (OR=0.56, 95%CI=0.40-0.80). No significant interaction was observed between MTHFR polymorphisms and lifestyle factors. Conclusion: Our findings suggest that the T-allele-carrying MTHFR C677T genotype or haplotype may reduce the risk of PMODs. However, these observations require further confirmation using larger samples. {\textcopyright} 2018 International Institute of Anticancer Research. All rights reserved.",
keywords = "Genetic polymorphism, Methylenetetrahydrofolate reductase, Potentially malignant oral disorders, Taiwan, 5,10 methylenetetrahydrofolate reductase (FADH2), genomic DNA, methylenetetrahydrofolate reductase (NADPH2), adult, alcohol consumption, allele, Article, carcinogenesis, cigarette smoking, comparative study, controlled study, genetic association, genotype, haplotype, human, lifestyle, major clinical study, male, molecular pathology, mouth carcinoma, potentially malignant oral disorder, priority journal, procedures, risk reduction, single nucleotide polymorphism, case control study, genetic predisposition, genetics, middle aged, mouth tumor, polymerase chain reaction, restriction fragment length polymorphism, Adult, Alleles, Case-Control Studies, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Methylenetetrahydrofolate Reductase (NADPH2), Middle Aged, Mouth Neoplasms, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Polymorphism, Single Nucleotide, Genetic polymorphism, Methylenetetrahydrofolate reductase, Potentially malignant oral disorders, Taiwan",
author = "T. Senghore and Y.-F. Li and F.-C. Sung and M.-H. Tsai and C.-H. Hua and C.-S. Liu and M.-F. Hung and C.-C. Yeh",
note = "Export Date: 18 October 2018 CODEN: ANTRD 通訊地址: Yeh, C.-C.; School of Public Health, Taipei Medical University, 250 Wu-Hsing Street, Taiwan; 電子郵件: ccyeh@tmu.edu.tw 化學物質/CAS: 5,10 methylenetetrahydrofolate reductase (FADH2), 9028-69-7; methylenetetrahydrofolate reductase (NADPH2), 71822-25-8; Methylenetetrahydrofolate Reductase (NADPH2) 參考文獻: Gupta, B., Johnson, N.W., Kumar, N., Global epidemiology of head and neck cancers: A continuing challenge (2016) Oncology, 91 (1), pp. 13-23; Chiang, C.-J., Lo, W.-C., Yang, Y.-W., You, S.-L., Chen, C.-J., Lai, M.S., Incidence and survival of adult cancer patients in Taiwan, 2002-2012 (2016) J Formosan Med Assoc, 115 (12), p. 13; Yang, P.Y., Chen, Y.T., Wang, Y.H., Su, N.Y., Yu, H.C., Chang, Y.C., Malignant transformation of oral submucous fibrosis in Taiwan: A nationwide population-based retrospective cohort study (2017) J Oral Pathol Med, 46 (10), pp. 1040-1045; Lyu, M.Y., Guo, Y.S., Li, S., Yang, D., Hua, H., Hospital-based epidemiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population (2017) Int Dent J, 67 (4), pp. 252-259; Paulino, Y.C., Hurwitz, E.L., Warnakulasuriya, S., Gatewood, R.R., Pierson, K.D., Tenorio, L.F., Novotny, R., Badowski, G., Screening for oral potentially malignant disorders among areca (betel) nut chewers in Guam and Saipan (2014) BMC Oral Health, 14, p. 151; Fenech, M., The role of folic acid and vitamin B12 in genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Miri-Moghaddam, E., Saravani, S., Garme, Y., Khosravi, A., Bazi, A., Motazedian, J., Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in South-East Iran (2016) J Oral Pathol Med, 45 (2), pp. 96-100; Weisberg, I., Tran, P., Christensen, B., Sibani, S., Rozen, R., A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity (1998) Mol Genet Metab, 64 (3), pp. 169-172; Fenech, M., The role of folic acid and vitamin B12 in genomic stability of human cells (2001) Mutat Res, 475 (1-2), pp. 57-67; Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., Rozen, R., A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase (1995) Nat Genet, 10 (1), pp. 111-113; Van Der Put, N.M., Gabreels, F., Stevens, E.M., Smeitink, J.A., Trijbels, F.J., Eskes, T.K., Van Den Heuvel, L.P., Blom, H.J., A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects? 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year = "2018",
language = "English",
volume = "38",
pages = "4021--4026",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "7",
}
