Abstract

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

Original languageEnglish
Article numbere0140549
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 22 2015

Fingerprint

osteoporosis
Polymorphism
Osteoporosis
Genes
Minerals
Bone
genetic polymorphism
Population
bone density
Bone Density
genes
pathogenesis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis. / Lu, Hsing Fang; Hung, Kuo Sheng; Hsu, Yu Wen; Tai, Yu-Ting; Huang, Lin Shan; Wang, Yu Jia; Wong, Henry Sung Ching; Hsu, Yi Hsiang; Chang, Wei Chiao.

In: PLoS One, Vol. 10, No. 10, e0140549, 22.10.2015.

Research output: Contribution to journalArticle

Lu, Hsing Fang ; Hung, Kuo Sheng ; Hsu, Yu Wen ; Tai, Yu-Ting ; Huang, Lin Shan ; Wang, Yu Jia ; Wong, Henry Sung Ching ; Hsu, Yi Hsiang ; Chang, Wei Chiao. / Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis. In: PLoS One. 2015 ; Vol. 10, No. 10.
@article{6cadd333beeb465993710b7b7d806294,
title = "Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis",
abstract = "Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.",
author = "Lu, {Hsing Fang} and Hung, {Kuo Sheng} and Hsu, {Yu Wen} and Yu-Ting Tai and Huang, {Lin Shan} and Wang, {Yu Jia} and Wong, {Henry Sung Ching} and Hsu, {Yi Hsiang} and Chang, {Wei Chiao}",
year = "2015",
month = "10",
day = "22",
doi = "10.1371/journal.pone.0140549",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

TY - JOUR

T1 - Association study between the FTCDNL1 (FONG) and susceptibility to osteoporosis

AU - Lu, Hsing Fang

AU - Hung, Kuo Sheng

AU - Hsu, Yu Wen

AU - Tai, Yu-Ting

AU - Huang, Lin Shan

AU - Wang, Yu Jia

AU - Wong, Henry Sung Ching

AU - Hsu, Yi Hsiang

AU - Chang, Wei Chiao

PY - 2015/10/22

Y1 - 2015/10/22

N2 - Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

AB - Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.

UR - http://www.scopus.com/inward/record.url?scp=84949467798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949467798&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0140549

DO - 10.1371/journal.pone.0140549

M3 - Article

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e0140549

ER -