Association of traumatic brain injury in childhood and attention-deficit/hyperactivity disorder: A population-based study

Ling Yu Yang, Chao Ching Huang, Wen Ta Chiu, Li Tung Huang, Wei Cheng Lo, Jia Yi Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background:We evaluated the risk of attention-deficit hyperactivity disorder (ADHD) following childhood traumatic brain injury (TBI).Methods:Using Taiwan's National Health Insurance Research Database, we included 10,416 newly diagnosed TBI children (aged ≤12 y) between 2001 and 2002 and 41,664 children without TBI, who were frequency matched by sex, age, and year of the index medical service with each TBI child, as controls. Children who had been diagnosed with ADHD prior to their medical service index were excluded. Each individual was followed for 9 y to identify ADHD diagnosis. We also compared the ADHD risk in children who were treated for fractures but not TBI as sensitivity analysis.Results:During the 9-y follow-up period, children with TBI had a higher ADHD risk (adjusted hazard ratio (AHR) = 1.32, 95% confidence interval (CI) = 1.19, 1.45) than did those without TBI. Furthermore, children with mild and severe TBI had higher AHRs for ADHD than did those without TBI (AHR = 1.30; 95% CI = 1.10, 1.53; and AHR = 1.37; 95% CI = 1.22, 1.55). However, no significant association was observed between fractures and ADHD.Conclusion:TBI in childhood is associated with a greater likelihood of developing ADHD.

Original languageEnglish
Pages (from-to)356-362
Number of pages7
JournalPediatric Research
Volume80
Issue number3
DOIs
Publication statusPublished - Sep 1 2016

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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