Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure

Kuan Yen Tung, Kuen Yuh Wu, Ching Hui Tsai, Ming Wei Su, Chien Han Chen, Ming Hung Lin, Yang Ching Chen, Wen Chia Wu, Yungling Leo Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction: Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and urinary cotinine level, and also determined the association of time inside the house on asthma phenotypes when children exposed to ETS. Methods: A total of 222 asthmatic children and 205 non-asthmatic controls were recruited in the Genetic and Biomarker study for Childhood Asthma (GBCA). Structured questionnaires and time-location pattern questionnaires were administered by face-to-face interview. Urinary cotinine was measured by liquid chromatography tandem mass spectrometry (LC/MS/MS). The level of household ETS exposure was assessed using the cotinine/creatinine ratio (CCR). Results: In general, urinary cotinine and CCR were higher in subjects exposed to household ETS than those who never had ETS at home. A significant positive relationship was found between average time inside the house and urinary CCR in asthmatic children with current ETS at home (β=0.278, p=0.02). After adjustment for age and gender, average time inside the house was positively related to severe wheeze in asthmatic children with household ETS within 1 month (OR: 1.26, 95%: 1.02-1.64). Conclusions: Our study suggests that the major source of ETS exposure for children is due to longer period of exposures among children living with adult smokers at home. Home-smoking restrictions that effectively prevent children from being exposed to ETS would be worthwhile.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalEnvironmental Research
Volume124
DOIs
Publication statusPublished - Jul 1 2013
Externally publishedYes

Fingerprint

Cotinine
Tobacco
Smoke
Creatinine
asthma
Asthma
exposure
tobacco smoke
household
Pulmonary diseases
respiratory disease
Liquid chromatography
Otitis Media
Biomarkers
indoor air
Tandem Mass Spectrometry
smoking
Liquid Chromatography
Mass spectrometry
biomarker

Keywords

  • Asthma phenotype
  • CCR
  • Environmental tobacco smoke
  • ETS
  • GBCA
  • Time inside the house
  • Time-location pattern
  • Urinary cotinine

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Science(all)

Cite this

Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure. / Tung, Kuan Yen; Wu, Kuen Yuh; Tsai, Ching Hui; Su, Ming Wei; Chen, Chien Han; Lin, Ming Hung; Chen, Yang Ching; Wu, Wen Chia; Lee, Yungling Leo.

In: Environmental Research, Vol. 124, 01.07.2013, p. 7-12.

Research output: Contribution to journalArticle

Tung, Kuan Yen ; Wu, Kuen Yuh ; Tsai, Ching Hui ; Su, Ming Wei ; Chen, Chien Han ; Lin, Ming Hung ; Chen, Yang Ching ; Wu, Wen Chia ; Lee, Yungling Leo. / Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure. In: Environmental Research. 2013 ; Vol. 124. pp. 7-12.
@article{68a56fe6288f4fb8aeeddfa0cdad5014,
title = "Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure",
abstract = "Introduction: Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and urinary cotinine level, and also determined the association of time inside the house on asthma phenotypes when children exposed to ETS. Methods: A total of 222 asthmatic children and 205 non-asthmatic controls were recruited in the Genetic and Biomarker study for Childhood Asthma (GBCA). Structured questionnaires and time-location pattern questionnaires were administered by face-to-face interview. Urinary cotinine was measured by liquid chromatography tandem mass spectrometry (LC/MS/MS). The level of household ETS exposure was assessed using the cotinine/creatinine ratio (CCR). Results: In general, urinary cotinine and CCR were higher in subjects exposed to household ETS than those who never had ETS at home. A significant positive relationship was found between average time inside the house and urinary CCR in asthmatic children with current ETS at home (β=0.278, p=0.02). After adjustment for age and gender, average time inside the house was positively related to severe wheeze in asthmatic children with household ETS within 1 month (OR: 1.26, 95{\%}: 1.02-1.64). Conclusions: Our study suggests that the major source of ETS exposure for children is due to longer period of exposures among children living with adult smokers at home. Home-smoking restrictions that effectively prevent children from being exposed to ETS would be worthwhile.",
keywords = "Asthma phenotype, CCR, Environmental tobacco smoke, ETS, GBCA, Time inside the house, Time-location pattern, Urinary cotinine",
author = "Tung, {Kuan Yen} and Wu, {Kuen Yuh} and Tsai, {Ching Hui} and Su, {Ming Wei} and Chen, {Chien Han} and Lin, {Ming Hung} and Chen, {Yang Ching} and Wu, {Wen Chia} and Lee, {Yungling Leo}",
year = "2013",
month = "7",
day = "1",
doi = "10.1016/j.envres.2013.03.002",
language = "English",
volume = "124",
pages = "7--12",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Association of time-location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure

AU - Tung, Kuan Yen

AU - Wu, Kuen Yuh

AU - Tsai, Ching Hui

AU - Su, Ming Wei

AU - Chen, Chien Han

AU - Lin, Ming Hung

AU - Chen, Yang Ching

AU - Wu, Wen Chia

AU - Lee, Yungling Leo

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Introduction: Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and urinary cotinine level, and also determined the association of time inside the house on asthma phenotypes when children exposed to ETS. Methods: A total of 222 asthmatic children and 205 non-asthmatic controls were recruited in the Genetic and Biomarker study for Childhood Asthma (GBCA). Structured questionnaires and time-location pattern questionnaires were administered by face-to-face interview. Urinary cotinine was measured by liquid chromatography tandem mass spectrometry (LC/MS/MS). The level of household ETS exposure was assessed using the cotinine/creatinine ratio (CCR). Results: In general, urinary cotinine and CCR were higher in subjects exposed to household ETS than those who never had ETS at home. A significant positive relationship was found between average time inside the house and urinary CCR in asthmatic children with current ETS at home (β=0.278, p=0.02). After adjustment for age and gender, average time inside the house was positively related to severe wheeze in asthmatic children with household ETS within 1 month (OR: 1.26, 95%: 1.02-1.64). Conclusions: Our study suggests that the major source of ETS exposure for children is due to longer period of exposures among children living with adult smokers at home. Home-smoking restrictions that effectively prevent children from being exposed to ETS would be worthwhile.

AB - Introduction: Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and urinary cotinine level, and also determined the association of time inside the house on asthma phenotypes when children exposed to ETS. Methods: A total of 222 asthmatic children and 205 non-asthmatic controls were recruited in the Genetic and Biomarker study for Childhood Asthma (GBCA). Structured questionnaires and time-location pattern questionnaires were administered by face-to-face interview. Urinary cotinine was measured by liquid chromatography tandem mass spectrometry (LC/MS/MS). The level of household ETS exposure was assessed using the cotinine/creatinine ratio (CCR). Results: In general, urinary cotinine and CCR were higher in subjects exposed to household ETS than those who never had ETS at home. A significant positive relationship was found between average time inside the house and urinary CCR in asthmatic children with current ETS at home (β=0.278, p=0.02). After adjustment for age and gender, average time inside the house was positively related to severe wheeze in asthmatic children with household ETS within 1 month (OR: 1.26, 95%: 1.02-1.64). Conclusions: Our study suggests that the major source of ETS exposure for children is due to longer period of exposures among children living with adult smokers at home. Home-smoking restrictions that effectively prevent children from being exposed to ETS would be worthwhile.

KW - Asthma phenotype

KW - CCR

KW - Environmental tobacco smoke

KW - ETS

KW - GBCA

KW - Time inside the house

KW - Time-location pattern

KW - Urinary cotinine

UR - http://www.scopus.com/inward/record.url?scp=84878403838&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878403838&partnerID=8YFLogxK

U2 - 10.1016/j.envres.2013.03.002

DO - 10.1016/j.envres.2013.03.002

M3 - Article

C2 - 23623351

AN - SCOPUS:84878403838

VL - 124

SP - 7

EP - 12

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -