Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization

Ching Chang Huang, Ying Hsien Chen, Mao Shin Lin, Cheng Hsin Lin, Hung Yuan Li, Ming Jang Chiu, Chi Chao Chao, Yen Wen Wu, Ya Fang Chen, Jen Kuang Lee, Ming Jiuh Wang, Ming Fong Chen, Hsien Li Kao

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives This study sought to report the effect of carotid artery stenting (CS) on neurocognitive function (NCF) in patients with severe carotid artery occlusive disease, depending on baseline brain perfusion status. Background The effect of CS on NCF has been controversial. Methods We prospectively enrolled 61 patients with carotid artery disease (22 with occlusion, 39 with severe stenosis) in whom CS was attempted. Computed tomography perfusion and NCF assessments including Mini-Mental State Examination (MMSE), Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog), verbal fluency, and Color Trails Test Parts 1 and 2 were applied before and 3 months after intervention. Results Successful recanalization was achieved in 14 of 22 occlusion patients (64%) and in all 39 severe stenosis patients. Two cases were excluded due to procedural cerebral complications. The patients were divided into 3 groups: group 1 (n = 8) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS failed; group 2 (n = 33) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS was successful; and group 3 (n = 19) consisted of patients without abnormal baseline ipsilateral cerebral perfusion in whom CS was successful. The demographics and baseline NCF were similar among groups. Only in group 2 was there significant improvement in ADAS-Cog (pre-procedure median [interquartile range]: 6 [4 to 9] vs. post-procedure: 5 [3 to 7], p = 0.002), MMSE (pre-procedure: 27 [25 to 28] vs. post-procedure: 28 [25 to 29], p = 0.004) and Color Trails Test Part 1 (pre-procedure: 100 [78.5 to 136.5] s vs. post-procedure: 97 [60 to 128.5] s, p = 0.003) after CS. Significant difference in changes from baseline was observed only in the Color Trails Test Part 1 among groups (group 1 vs. 2 vs. 3: 1.5 [-14 to 11.5] vs. -12.5 [-36.5 to 0.5] vs. -0.5 [-11 to 27], p = 0.0159). Significant correlation between the change of ipsilateral brain perfusion and MMSE (r = -0.33, p = 0.01) was also identified. Conclusions Successful CS for severe carotid stenosis/occlusion improves NCF, but only in patients with objective baseline abnormal cerebral perfusion.

Original languageEnglish
Pages (from-to)2503-2509
Number of pages7
JournalJournal of the American College of Cardiology
Volume61
Issue number25
DOIs
Publication statusPublished - Jun 25 2013
Externally publishedYes

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Carotid Arteries
Perfusion
Carotid Artery Diseases
Color
Alzheimer Disease
Pathologic Constriction
Carotid Stenosis
Brain
Tomography
Demography

Keywords

  • brain perfusion
  • carotid stenosis
  • carotid stenting
  • neurocognitive function

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization. / Huang, Ching Chang; Chen, Ying Hsien; Lin, Mao Shin; Lin, Cheng Hsin; Li, Hung Yuan; Chiu, Ming Jang; Chao, Chi Chao; Wu, Yen Wen; Chen, Ya Fang; Lee, Jen Kuang; Wang, Ming Jiuh; Chen, Ming Fong; Kao, Hsien Li.

In: Journal of the American College of Cardiology, Vol. 61, No. 25, 25.06.2013, p. 2503-2509.

Research output: Contribution to journalArticle

Huang, CC, Chen, YH, Lin, MS, Lin, CH, Li, HY, Chiu, MJ, Chao, CC, Wu, YW, Chen, YF, Lee, JK, Wang, MJ, Chen, MF & Kao, HL 2013, 'Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization', Journal of the American College of Cardiology, vol. 61, no. 25, pp. 2503-2509. https://doi.org/10.1016/j.jacc.2013.02.059
Huang, Ching Chang ; Chen, Ying Hsien ; Lin, Mao Shin ; Lin, Cheng Hsin ; Li, Hung Yuan ; Chiu, Ming Jang ; Chao, Chi Chao ; Wu, Yen Wen ; Chen, Ya Fang ; Lee, Jen Kuang ; Wang, Ming Jiuh ; Chen, Ming Fong ; Kao, Hsien Li. / Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization. In: Journal of the American College of Cardiology. 2013 ; Vol. 61, No. 25. pp. 2503-2509.
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abstract = "Objectives This study sought to report the effect of carotid artery stenting (CS) on neurocognitive function (NCF) in patients with severe carotid artery occlusive disease, depending on baseline brain perfusion status. Background The effect of CS on NCF has been controversial. Methods We prospectively enrolled 61 patients with carotid artery disease (22 with occlusion, 39 with severe stenosis) in whom CS was attempted. Computed tomography perfusion and NCF assessments including Mini-Mental State Examination (MMSE), Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog), verbal fluency, and Color Trails Test Parts 1 and 2 were applied before and 3 months after intervention. Results Successful recanalization was achieved in 14 of 22 occlusion patients (64{\%}) and in all 39 severe stenosis patients. Two cases were excluded due to procedural cerebral complications. The patients were divided into 3 groups: group 1 (n = 8) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS failed; group 2 (n = 33) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS was successful; and group 3 (n = 19) consisted of patients without abnormal baseline ipsilateral cerebral perfusion in whom CS was successful. The demographics and baseline NCF were similar among groups. Only in group 2 was there significant improvement in ADAS-Cog (pre-procedure median [interquartile range]: 6 [4 to 9] vs. post-procedure: 5 [3 to 7], p = 0.002), MMSE (pre-procedure: 27 [25 to 28] vs. post-procedure: 28 [25 to 29], p = 0.004) and Color Trails Test Part 1 (pre-procedure: 100 [78.5 to 136.5] s vs. post-procedure: 97 [60 to 128.5] s, p = 0.003) after CS. Significant difference in changes from baseline was observed only in the Color Trails Test Part 1 among groups (group 1 vs. 2 vs. 3: 1.5 [-14 to 11.5] vs. -12.5 [-36.5 to 0.5] vs. -0.5 [-11 to 27], p = 0.0159). Significant correlation between the change of ipsilateral brain perfusion and MMSE (r = -0.33, p = 0.01) was also identified. Conclusions Successful CS for severe carotid stenosis/occlusion improves NCF, but only in patients with objective baseline abnormal cerebral perfusion.",
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T1 - Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization

AU - Huang, Ching Chang

AU - Chen, Ying Hsien

AU - Lin, Mao Shin

AU - Lin, Cheng Hsin

AU - Li, Hung Yuan

AU - Chiu, Ming Jang

AU - Chao, Chi Chao

AU - Wu, Yen Wen

AU - Chen, Ya Fang

AU - Lee, Jen Kuang

AU - Wang, Ming Jiuh

AU - Chen, Ming Fong

AU - Kao, Hsien Li

PY - 2013/6/25

Y1 - 2013/6/25

N2 - Objectives This study sought to report the effect of carotid artery stenting (CS) on neurocognitive function (NCF) in patients with severe carotid artery occlusive disease, depending on baseline brain perfusion status. Background The effect of CS on NCF has been controversial. Methods We prospectively enrolled 61 patients with carotid artery disease (22 with occlusion, 39 with severe stenosis) in whom CS was attempted. Computed tomography perfusion and NCF assessments including Mini-Mental State Examination (MMSE), Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog), verbal fluency, and Color Trails Test Parts 1 and 2 were applied before and 3 months after intervention. Results Successful recanalization was achieved in 14 of 22 occlusion patients (64%) and in all 39 severe stenosis patients. Two cases were excluded due to procedural cerebral complications. The patients were divided into 3 groups: group 1 (n = 8) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS failed; group 2 (n = 33) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS was successful; and group 3 (n = 19) consisted of patients without abnormal baseline ipsilateral cerebral perfusion in whom CS was successful. The demographics and baseline NCF were similar among groups. Only in group 2 was there significant improvement in ADAS-Cog (pre-procedure median [interquartile range]: 6 [4 to 9] vs. post-procedure: 5 [3 to 7], p = 0.002), MMSE (pre-procedure: 27 [25 to 28] vs. post-procedure: 28 [25 to 29], p = 0.004) and Color Trails Test Part 1 (pre-procedure: 100 [78.5 to 136.5] s vs. post-procedure: 97 [60 to 128.5] s, p = 0.003) after CS. Significant difference in changes from baseline was observed only in the Color Trails Test Part 1 among groups (group 1 vs. 2 vs. 3: 1.5 [-14 to 11.5] vs. -12.5 [-36.5 to 0.5] vs. -0.5 [-11 to 27], p = 0.0159). Significant correlation between the change of ipsilateral brain perfusion and MMSE (r = -0.33, p = 0.01) was also identified. Conclusions Successful CS for severe carotid stenosis/occlusion improves NCF, but only in patients with objective baseline abnormal cerebral perfusion.

AB - Objectives This study sought to report the effect of carotid artery stenting (CS) on neurocognitive function (NCF) in patients with severe carotid artery occlusive disease, depending on baseline brain perfusion status. Background The effect of CS on NCF has been controversial. Methods We prospectively enrolled 61 patients with carotid artery disease (22 with occlusion, 39 with severe stenosis) in whom CS was attempted. Computed tomography perfusion and NCF assessments including Mini-Mental State Examination (MMSE), Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-Cog), verbal fluency, and Color Trails Test Parts 1 and 2 were applied before and 3 months after intervention. Results Successful recanalization was achieved in 14 of 22 occlusion patients (64%) and in all 39 severe stenosis patients. Two cases were excluded due to procedural cerebral complications. The patients were divided into 3 groups: group 1 (n = 8) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS failed; group 2 (n = 33) consisted of patients with abnormal baseline ipsilateral cerebral perfusion in whom CS was successful; and group 3 (n = 19) consisted of patients without abnormal baseline ipsilateral cerebral perfusion in whom CS was successful. The demographics and baseline NCF were similar among groups. Only in group 2 was there significant improvement in ADAS-Cog (pre-procedure median [interquartile range]: 6 [4 to 9] vs. post-procedure: 5 [3 to 7], p = 0.002), MMSE (pre-procedure: 27 [25 to 28] vs. post-procedure: 28 [25 to 29], p = 0.004) and Color Trails Test Part 1 (pre-procedure: 100 [78.5 to 136.5] s vs. post-procedure: 97 [60 to 128.5] s, p = 0.003) after CS. Significant difference in changes from baseline was observed only in the Color Trails Test Part 1 among groups (group 1 vs. 2 vs. 3: 1.5 [-14 to 11.5] vs. -12.5 [-36.5 to 0.5] vs. -0.5 [-11 to 27], p = 0.0159). Significant correlation between the change of ipsilateral brain perfusion and MMSE (r = -0.33, p = 0.01) was also identified. Conclusions Successful CS for severe carotid stenosis/occlusion improves NCF, but only in patients with objective baseline abnormal cerebral perfusion.

KW - brain perfusion

KW - carotid stenosis

KW - carotid stenting

KW - neurocognitive function

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