Association of the PPAR-γ gene with altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics

Yun Ru Liu, Tsung Ming Hu, Tsuo Hung Lan, Hsien Jane Chiu, Yung Han Chang, Shuo Fei Chen, Yen Hsin Yu, Cheng Chung Chen, El Wui Loh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Metabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics. Methods: Single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS). Results: SNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile. Conclusion: Our study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalPsychiatry Investigation
Volume11
Issue number2
DOIs
Publication statusPublished - 2014

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Peroxisome Proliferator-Activated Receptors
Psychotic Disorders
Antipsychotic Agents
Schizophrenia
Glucose
Single Nucleotide Polymorphism
Genes
Retinoid X Receptors
Glycosylated Hemoglobin A
Lipid Metabolism
Haplotypes
Exons
Fasting
Triglycerides
Obesity
Lipids

Keywords

  • Glucose
  • PPAR-γ gene
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Association of the PPAR-γ gene with altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. / Liu, Yun Ru; Hu, Tsung Ming; Lan, Tsuo Hung; Chiu, Hsien Jane; Chang, Yung Han; Chen, Shuo Fei; Yu, Yen Hsin; Chen, Cheng Chung; Loh, El Wui.

In: Psychiatry Investigation, Vol. 11, No. 2, 2014, p. 179-185.

Research output: Contribution to journalArticle

Liu, Yun Ru ; Hu, Tsung Ming ; Lan, Tsuo Hung ; Chiu, Hsien Jane ; Chang, Yung Han ; Chen, Shuo Fei ; Yu, Yen Hsin ; Chen, Cheng Chung ; Loh, El Wui. / Association of the PPAR-γ gene with altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. In: Psychiatry Investigation. 2014 ; Vol. 11, No. 2. pp. 179-185.
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AU - Chen, Shuo Fei

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AB - Objective: Metabolic abnormalities, e.g., diabetes, are common among schizophrenia patients. Peroxisome proliferator activated receptor-γ (PPAR-γ) regulates glucose/lipid metabolisms, and schizophrenia like syndrome may be induced by actions involving retinoid X receptor-α/PPAR-γ heterodimers. We examined a possible role of the PPAR-γ gene in metabolic traits and psychosis profile in schizophrenia patients exposed to antipsychotics. Methods: Single nucleotide polymorphisms (SNPs) of the PPAR-γ gene and a serial of metabolic traits were determined in 394 schizophrenia patients, among which 372 were rated with Positive and Negative Syndrome Scale (PANSS). Results: SNP-10, -12, -18, -19, -20 and -26 were associated with glycated hemoglobin (HbA1c) whereas SNP-18, -19, -20 and -26 were associated with fasting plasma glucose (FPG). While SNP-23 was associated with triglycerides, no associations were identified between the other SNPs and lipids. Further haplotype analysis demonstrated an association between the PPAR-γ gene and psychosis profile. Conclusion: Our study suggests a role of the PPAR-γ gene in altered glucose levels and psychosis profile in schizophrenia patients exposed to antipsychotics. Although the Pro12Ala at exon B has been concerned an essential variant in the development of obesity, the lack of association of the variant with metabolic traits in this study should not be treated as impossibility or a proof of error because other factors, e.g., genes regulated by PPAR-γ, may have complicated the development of metabolic abnormalities. Whether the PPAR-γ gene modifies the risk of metabolic abnormalities or psychosis, or causes metabolic abnormalities that lead to psychosis, remains to be examined.

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