Abstract

© 2017, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. Introduction: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients. In the present study, we explored the association of different stroke subtypes and several comorbidities with poststroke HF. Methods: A population-based study was conducted using National Health Insurance Research Database (NHIRD) of Taiwan. First, we identified 17,168 patients diagnosed as having a stroke between January 1, 2002, and December 31, 2010. Then, we randomly selected 51,504 controls that never had a stroke and matched these controls to stroke patients in a 1:3 ratio by age (± 1 year old) and gender. Cox proportional hazards model was used to estimate hazard ratio (HR) and 95% confidence interval (CI). Results: Stroke patients had a significantly higher risk of HF (HR = 1.69). Female and male stroke patients had incidence rate ratios (IRRs) of 2.05 and 1.82 for HF, respectively. Significantly increased IRRs of 1.82, 1.52, and 2.63 for HF were found for stroke patients with 0, 1, and ≥ 2 comorbidities, respectively. All stroke patients, ischemic stroke patients, and intracerebral hemorrhagic (ICH) patients had HF risks of 1.65, 1.60, and 2.34, respectively. Conclusion: Overall, stroke significantly increases the incidence of HF, and the risk of HF is significantly higher in ICH patients and female gender. We should identify stroke patients at risk of HF and pay more attention to prevent them from fall in poststroke long-term care.
Original languageEnglish
JournalArchives of Osteoporosis
Volume12
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Hip Fractures
Taiwan
Stroke
Population
Comorbidity
National Health Programs
Osteoporosis
Incidence
Accidental Falls
Databases
Sarcopenia
Long-Term Care
Proportional Hazards Models
Research
Immobilization

Keywords

  • Longitudinal health insurance database
  • Post-stroke hip fracture
  • Public health
  • Stroke

Cite this

@article{e53d99ba3bbb4664abfc2220e152614b,
title = "Association of stroke subtypes with risk of hip fracture: a population-based study in Taiwan",
abstract = "{\circledC} 2017, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. Introduction: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients. In the present study, we explored the association of different stroke subtypes and several comorbidities with poststroke HF. Methods: A population-based study was conducted using National Health Insurance Research Database (NHIRD) of Taiwan. First, we identified 17,168 patients diagnosed as having a stroke between January 1, 2002, and December 31, 2010. Then, we randomly selected 51,504 controls that never had a stroke and matched these controls to stroke patients in a 1:3 ratio by age (± 1 year old) and gender. Cox proportional hazards model was used to estimate hazard ratio (HR) and 95{\%} confidence interval (CI). Results: Stroke patients had a significantly higher risk of HF (HR = 1.69). Female and male stroke patients had incidence rate ratios (IRRs) of 2.05 and 1.82 for HF, respectively. Significantly increased IRRs of 1.82, 1.52, and 2.63 for HF were found for stroke patients with 0, 1, and ≥ 2 comorbidities, respectively. All stroke patients, ischemic stroke patients, and intracerebral hemorrhagic (ICH) patients had HF risks of 1.65, 1.60, and 2.34, respectively. Conclusion: Overall, stroke significantly increases the incidence of HF, and the risk of HF is significantly higher in ICH patients and female gender. We should identify stroke patients at risk of HF and pay more attention to prevent them from fall in poststroke long-term care.",
keywords = "Longitudinal health insurance database, Post-stroke hip fracture, Public health, Stroke",
author = "Zheng, {Jing Quan} and Lai, {Hui Ju} and Zheng, {Cai Mei} and Yen, {Yu Chun} and Lu, {Kuo Cheng} and Hu, {Chaur Jong} and Lee, {Hsun Hua} and Wang, {Yuan Hung}",
year = "2017",
month = "12",
day = "1",
doi = "10.1007/s11657-017-0390-8",
language = "English",
volume = "12",
journal = "Archives of Osteoporosis",
issn = "1862-3522",
publisher = "Springer London",
number = "1",

}

TY - JOUR

T1 - Association of stroke subtypes with risk of hip fracture: a population-based study in Taiwan

AU - Zheng, Jing Quan

AU - Lai, Hui Ju

AU - Zheng, Cai Mei

AU - Yen, Yu Chun

AU - Lu, Kuo Cheng

AU - Hu, Chaur Jong

AU - Lee, Hsun Hua

AU - Wang, Yuan Hung

PY - 2017/12/1

Y1 - 2017/12/1

N2 - © 2017, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. Introduction: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients. In the present study, we explored the association of different stroke subtypes and several comorbidities with poststroke HF. Methods: A population-based study was conducted using National Health Insurance Research Database (NHIRD) of Taiwan. First, we identified 17,168 patients diagnosed as having a stroke between January 1, 2002, and December 31, 2010. Then, we randomly selected 51,504 controls that never had a stroke and matched these controls to stroke patients in a 1:3 ratio by age (± 1 year old) and gender. Cox proportional hazards model was used to estimate hazard ratio (HR) and 95% confidence interval (CI). Results: Stroke patients had a significantly higher risk of HF (HR = 1.69). Female and male stroke patients had incidence rate ratios (IRRs) of 2.05 and 1.82 for HF, respectively. Significantly increased IRRs of 1.82, 1.52, and 2.63 for HF were found for stroke patients with 0, 1, and ≥ 2 comorbidities, respectively. All stroke patients, ischemic stroke patients, and intracerebral hemorrhagic (ICH) patients had HF risks of 1.65, 1.60, and 2.34, respectively. Conclusion: Overall, stroke significantly increases the incidence of HF, and the risk of HF is significantly higher in ICH patients and female gender. We should identify stroke patients at risk of HF and pay more attention to prevent them from fall in poststroke long-term care.

AB - © 2017, International Osteoporosis Foundation and National Osteoporosis Foundation. Summary: Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. Introduction: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients. In the present study, we explored the association of different stroke subtypes and several comorbidities with poststroke HF. Methods: A population-based study was conducted using National Health Insurance Research Database (NHIRD) of Taiwan. First, we identified 17,168 patients diagnosed as having a stroke between January 1, 2002, and December 31, 2010. Then, we randomly selected 51,504 controls that never had a stroke and matched these controls to stroke patients in a 1:3 ratio by age (± 1 year old) and gender. Cox proportional hazards model was used to estimate hazard ratio (HR) and 95% confidence interval (CI). Results: Stroke patients had a significantly higher risk of HF (HR = 1.69). Female and male stroke patients had incidence rate ratios (IRRs) of 2.05 and 1.82 for HF, respectively. Significantly increased IRRs of 1.82, 1.52, and 2.63 for HF were found for stroke patients with 0, 1, and ≥ 2 comorbidities, respectively. All stroke patients, ischemic stroke patients, and intracerebral hemorrhagic (ICH) patients had HF risks of 1.65, 1.60, and 2.34, respectively. Conclusion: Overall, stroke significantly increases the incidence of HF, and the risk of HF is significantly higher in ICH patients and female gender. We should identify stroke patients at risk of HF and pay more attention to prevent them from fall in poststroke long-term care.

KW - Longitudinal health insurance database

KW - Post-stroke hip fracture

KW - Public health

KW - Stroke

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