Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa

Kristin E. Anderson, Thomas A. Sellers, Ping Ling Chen, Stephen S. Rich, Ching Ping Hong, Aaron R. Folsom

Research output: Contribution to journalArticle

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Abstract

BACKGROUND. The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity. Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992. METHODS. All participants were between the ages of 55 and 69 and held a valid Iowa driver's license. A total of 472 women in the cohort (1.35%) reported a history of SLS at baseline. Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa. Data were analyzed using Cox proportional hazards regression. RESULTS. During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS. Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI). Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P <0.01), they were not more likely to develop breast carcinoma (relative risk [RR] = 1.2; 95% confidence interval [CI] = 0.7-2. Adjustment for age at menarche, age at menopause, parity oral contraceptive use BMI, waist-to-hip ratio, and family history of breast carcinoma lowered the RR to 1 (95% CI = 0.6-1.9). CONCLUSIONS. Despite the high risk profiles of some women with SLS, these results do not suggest that the syndrome per se is associated with an increased risk of postmenopausal breast carcinoma.

Original languageEnglish
Pages (from-to)494-499
Number of pages6
JournalCancer
Volume79
Issue number3
DOIs
Publication statusPublished - Feb 1 1997

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Polycystic Ovary Syndrome
Prospective Studies
Breast Neoplasms
Incidence
Body Mass Index
Confidence Intervals
Breast Diseases
Menarche
Waist-Hip Ratio
Licensure
Oral Contraceptives
Menopause
Parity
Infertility
Fertility
Registries
Obesity
Phenotype
Health

Keywords

  • breast carcinoma
  • cohort
  • polycystic ovaries
  • postmenopausal
  • Stein-Leventhal syndrome

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. / Anderson, Kristin E.; Sellers, Thomas A.; Chen, Ping Ling; Rich, Stephen S.; Hong, Ching Ping; Folsom, Aaron R.

In: Cancer, Vol. 79, No. 3, 01.02.1997, p. 494-499.

Research output: Contribution to journalArticle

Anderson, Kristin E. ; Sellers, Thomas A. ; Chen, Ping Ling ; Rich, Stephen S. ; Hong, Ching Ping ; Folsom, Aaron R. / Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. In: Cancer. 1997 ; Vol. 79, No. 3. pp. 494-499.
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abstract = "BACKGROUND. The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity. Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992. METHODS. All participants were between the ages of 55 and 69 and held a valid Iowa driver's license. A total of 472 women in the cohort (1.35{\%}) reported a history of SLS at baseline. Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa. Data were analyzed using Cox proportional hazards regression. RESULTS. During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS. Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI). Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P <0.01), they were not more likely to develop breast carcinoma (relative risk [RR] = 1.2; 95{\%} confidence interval [CI] = 0.7-2. Adjustment for age at menarche, age at menopause, parity oral contraceptive use BMI, waist-to-hip ratio, and family history of breast carcinoma lowered the RR to 1 (95{\%} CI = 0.6-1.9). CONCLUSIONS. Despite the high risk profiles of some women with SLS, these results do not suggest that the syndrome per se is associated with an increased risk of postmenopausal breast carcinoma.",
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T1 - Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa

AU - Anderson, Kristin E.

AU - Sellers, Thomas A.

AU - Chen, Ping Ling

AU - Rich, Stephen S.

AU - Hong, Ching Ping

AU - Folsom, Aaron R.

PY - 1997/2/1

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N2 - BACKGROUND. The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity. Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992. METHODS. All participants were between the ages of 55 and 69 and held a valid Iowa driver's license. A total of 472 women in the cohort (1.35%) reported a history of SLS at baseline. Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa. Data were analyzed using Cox proportional hazards regression. RESULTS. During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS. Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI). Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P <0.01), they were not more likely to develop breast carcinoma (relative risk [RR] = 1.2; 95% confidence interval [CI] = 0.7-2. Adjustment for age at menarche, age at menopause, parity oral contraceptive use BMI, waist-to-hip ratio, and family history of breast carcinoma lowered the RR to 1 (95% CI = 0.6-1.9). CONCLUSIONS. Despite the high risk profiles of some women with SLS, these results do not suggest that the syndrome per se is associated with an increased risk of postmenopausal breast carcinoma.

AB - BACKGROUND. The Stein-Leventhal syndrome (SLS), first described in 1935, is characterized by infertility, hyperandrogenization, and obesity. Because this phenotype represents an aggregation of risk factors for postmenopausal breast carcinoma and because in general, a hormonal imbalance underlies the disorder, the authors examined the association between self-reported SLS and breast carcinoma incidence in a cohort of 34,835 cancer-free women assembled in 1986 and followed through 1992. METHODS. All participants were between the ages of 55 and 69 and held a valid Iowa driver's license. A total of 472 women in the cohort (1.35%) reported a history of SLS at baseline. Incident cases of breast carcinoma were identified annually using the State Health Registry of Iowa. Data were analyzed using Cox proportional hazards regression. RESULTS. During the follow-up period, there were 883 incident breast carcinomas, 14 among women reporting a history of SLS. Women with SLS were more likely than women without SLS to report fertility problems and menstrual irregularities, but there were no significant differences observed regarding body mass index (BMI). Although women with SLS were 1.8 times as likely to report benign breast disease than women without SLS (P <0.01), they were not more likely to develop breast carcinoma (relative risk [RR] = 1.2; 95% confidence interval [CI] = 0.7-2. Adjustment for age at menarche, age at menopause, parity oral contraceptive use BMI, waist-to-hip ratio, and family history of breast carcinoma lowered the RR to 1 (95% CI = 0.6-1.9). CONCLUSIONS. Despite the high risk profiles of some women with SLS, these results do not suggest that the syndrome per se is associated with an increased risk of postmenopausal breast carcinoma.

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KW - polycystic ovaries

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