Association of small-conductance calcium-activated potassium channels and atrial fibrillation - How far have we gone?

Shu Hsuan Chang, Sheng Nan Chang, Lian Yu Lin, Ling Ping Lai, Chuen Den Tseng, Yi Chih Wang, Chih Chieh Yu, Fu Tien Chiang, Juey Jen Hwang, Jiunn-Lee Lin, Chia Ti Tsai

Research output: Contribution to journalReview article

Abstract

Atrial fibrillation (AF) is the most common sustained and most important arrhythmia in clinical practice. The mechanisms underlying AF initiation and maintenance are known to be complex and heterogeneous. The general understanding of the detailed molecular basis of AF is still incomplete. Recently, these is increasing evidence that small conductance calcium-activated potassium (SK) channels are associated with atrial action potential repolarization and the pathogenesis of AF. Although the functional role of SK channels in the genesis of AF is not entirely clear, new insights into the basic pathophysiological mechanism of AF have been provided. Besides, genome-wide association studies also implicate that genes coding for SK channels are related to the risk of developing AF. This article reviews recent work on the association of SK channels and AF, genetic studies of SK channels, and discuss future investigation and developments regarding this field.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalActa Cardiologica Sinica
Volume30
Issue number1
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Small-Conductance Calcium-Activated Potassium Channels
Atrial Fibrillation
Genome-Wide Association Study
Action Potentials
Cardiac Arrhythmias
Maintenance

Keywords

  • Atrial fibrillation
  • Genetics
  • Small conductance calcium-activated potassium channels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Chang, S. H., Chang, S. N., Lin, L. Y., Lai, L. P., Tseng, C. D., Wang, Y. C., ... Tsai, C. T. (2014). Association of small-conductance calcium-activated potassium channels and atrial fibrillation - How far have we gone? Acta Cardiologica Sinica, 30(1), 10-15.

Association of small-conductance calcium-activated potassium channels and atrial fibrillation - How far have we gone? / Chang, Shu Hsuan; Chang, Sheng Nan; Lin, Lian Yu; Lai, Ling Ping; Tseng, Chuen Den; Wang, Yi Chih; Yu, Chih Chieh; Chiang, Fu Tien; Hwang, Juey Jen; Lin, Jiunn-Lee; Tsai, Chia Ti.

In: Acta Cardiologica Sinica, Vol. 30, No. 1, 01.01.2014, p. 10-15.

Research output: Contribution to journalReview article

Chang, SH, Chang, SN, Lin, LY, Lai, LP, Tseng, CD, Wang, YC, Yu, CC, Chiang, FT, Hwang, JJ, Lin, J-L & Tsai, CT 2014, 'Association of small-conductance calcium-activated potassium channels and atrial fibrillation - How far have we gone?', Acta Cardiologica Sinica, vol. 30, no. 1, pp. 10-15.
Chang, Shu Hsuan ; Chang, Sheng Nan ; Lin, Lian Yu ; Lai, Ling Ping ; Tseng, Chuen Den ; Wang, Yi Chih ; Yu, Chih Chieh ; Chiang, Fu Tien ; Hwang, Juey Jen ; Lin, Jiunn-Lee ; Tsai, Chia Ti. / Association of small-conductance calcium-activated potassium channels and atrial fibrillation - How far have we gone?. In: Acta Cardiologica Sinica. 2014 ; Vol. 30, No. 1. pp. 10-15.
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AU - Tseng, Chuen Den

AU - Wang, Yi Chih

AU - Yu, Chih Chieh

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AB - Atrial fibrillation (AF) is the most common sustained and most important arrhythmia in clinical practice. The mechanisms underlying AF initiation and maintenance are known to be complex and heterogeneous. The general understanding of the detailed molecular basis of AF is still incomplete. Recently, these is increasing evidence that small conductance calcium-activated potassium (SK) channels are associated with atrial action potential repolarization and the pathogenesis of AF. Although the functional role of SK channels in the genesis of AF is not entirely clear, new insights into the basic pathophysiological mechanism of AF have been provided. Besides, genome-wide association studies also implicate that genes coding for SK channels are related to the risk of developing AF. This article reviews recent work on the association of SK channels and AF, genetic studies of SK channels, and discuss future investigation and developments regarding this field.

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