Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects

Chang Fu Wu, Fu Hui Shen, Ya Ru Li, Tsung Ming Tsao, Ming Jer Tsai, Chu Chih Chen, Jing Shiang Hwang, Sandy Huey Jen Hsu, Hsing Chao, Kai Jen Chuang, Charles C K Chou, Ya Nan Wang, Chi Chang Ho, Ta Chen Su

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations approximately 8 months apart in 2013. Brachial–ankle pulse wave velocity (baPWV), a physiological indicator of arterial stiffness, and high-sensitivity C-reactive protein (hsCRP), a biomarker of vascular inflammations, were measured during each examination. Two exposure assessment methods were used for estimating the subjects' exposure to PM2.5 and NO2. The first method involved constructing daily land use regression (LUR) models according to measurements collected at ambient air quality monitoring stations. The second method required combining the LUR estimates with indoor monitoring data at the workplace of the subjects. Linear mixed models were used to examine the association between the exposure estimates and health outcomes. The results showed that a 10-μg/m3 increase in PM2.5 concentration at a 1-day lag was associated with 2.1% (95% confidence interval: 0.7%–3.6%) and 2.4% (0.8%–4.0%) increases in baPWV based on the two exposure assessment methods, whereas no significant association was observed for NO2. The significant effects of PM2.5 remained in the two-pollutant models. By contrast, NO2, but not PM2.5, was significantly associated with increased hsCRP levels (16.0%–37.3% in single-pollutant models and 26.4%–44.6% in two-pollutant models, per 10-ppb increase in NO2). In conclusion, arterial stiffness might be more sensitive to short-term PM2.5 exposure than is inflammation.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalScience of the Total Environment
Volume569-570
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Nitrogen Dioxide
Particulate Matter
nitrogen dioxide
particulate matter
Nitrogen
Land use
C-Reactive Protein
assessment method
Stiffness
wave velocity
Health
pollutant
Association reactions
stiffness
Proteins
Monitoring
land use
Biomarkers
protein
Air quality

Keywords

  • Air pollution
  • Arterial stiffness
  • Cardiovascular
  • Inflammation
  • Land use regression

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering

Cite this

Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects. / Wu, Chang Fu; Shen, Fu Hui; Li, Ya Ru; Tsao, Tsung Ming; Tsai, Ming Jer; Chen, Chu Chih; Hwang, Jing Shiang; Hsu, Sandy Huey Jen; Chao, Hsing; Chuang, Kai Jen; Chou, Charles C K; Wang, Ya Nan; Ho, Chi Chang; Su, Ta Chen.

In: Science of the Total Environment, Vol. 569-570, 01.11.2016, p. 300-305.

Research output: Contribution to journalArticle

Wu, CF, Shen, FH, Li, YR, Tsao, TM, Tsai, MJ, Chen, CC, Hwang, JS, Hsu, SHJ, Chao, H, Chuang, KJ, Chou, CCK, Wang, YN, Ho, CC & Su, TC 2016, 'Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects', Science of the Total Environment, vol. 569-570, pp. 300-305. https://doi.org/10.1016/j.scitotenv.2016.06.084
Wu, Chang Fu ; Shen, Fu Hui ; Li, Ya Ru ; Tsao, Tsung Ming ; Tsai, Ming Jer ; Chen, Chu Chih ; Hwang, Jing Shiang ; Hsu, Sandy Huey Jen ; Chao, Hsing ; Chuang, Kai Jen ; Chou, Charles C K ; Wang, Ya Nan ; Ho, Chi Chang ; Su, Ta Chen. / Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects. In: Science of the Total Environment. 2016 ; Vol. 569-570. pp. 300-305.
@article{a2a6f8a201e042d88a17a7a5c122da42,
title = "Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects",
abstract = "This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations approximately 8 months apart in 2013. Brachial–ankle pulse wave velocity (baPWV), a physiological indicator of arterial stiffness, and high-sensitivity C-reactive protein (hsCRP), a biomarker of vascular inflammations, were measured during each examination. Two exposure assessment methods were used for estimating the subjects' exposure to PM2.5 and NO2. The first method involved constructing daily land use regression (LUR) models according to measurements collected at ambient air quality monitoring stations. The second method required combining the LUR estimates with indoor monitoring data at the workplace of the subjects. Linear mixed models were used to examine the association between the exposure estimates and health outcomes. The results showed that a 10-μg/m3 increase in PM2.5 concentration at a 1-day lag was associated with 2.1{\%} (95{\%} confidence interval: 0.7{\%}–3.6{\%}) and 2.4{\%} (0.8{\%}–4.0{\%}) increases in baPWV based on the two exposure assessment methods, whereas no significant association was observed for NO2. The significant effects of PM2.5 remained in the two-pollutant models. By contrast, NO2, but not PM2.5, was significantly associated with increased hsCRP levels (16.0{\%}–37.3{\%} in single-pollutant models and 26.4{\%}–44.6{\%} in two-pollutant models, per 10-ppb increase in NO2). In conclusion, arterial stiffness might be more sensitive to short-term PM2.5 exposure than is inflammation.",
keywords = "Air pollution, Arterial stiffness, Cardiovascular, Inflammation, Land use regression",
author = "Wu, {Chang Fu} and Shen, {Fu Hui} and Li, {Ya Ru} and Tsao, {Tsung Ming} and Tsai, {Ming Jer} and Chen, {Chu Chih} and Hwang, {Jing Shiang} and Hsu, {Sandy Huey Jen} and Hsing Chao and Chuang, {Kai Jen} and Chou, {Charles C K} and Wang, {Ya Nan} and Ho, {Chi Chang} and Su, {Ta Chen}",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.scitotenv.2016.06.084",
language = "English",
volume = "569-570",
pages = "300--305",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

TY - JOUR

T1 - Association of short-term exposure to fine particulate matter and nitrogen dioxide with acute cardiovascular effects

AU - Wu, Chang Fu

AU - Shen, Fu Hui

AU - Li, Ya Ru

AU - Tsao, Tsung Ming

AU - Tsai, Ming Jer

AU - Chen, Chu Chih

AU - Hwang, Jing Shiang

AU - Hsu, Sandy Huey Jen

AU - Chao, Hsing

AU - Chuang, Kai Jen

AU - Chou, Charles C K

AU - Wang, Ya Nan

AU - Ho, Chi Chang

AU - Su, Ta Chen

PY - 2016/11/1

Y1 - 2016/11/1

N2 - This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations approximately 8 months apart in 2013. Brachial–ankle pulse wave velocity (baPWV), a physiological indicator of arterial stiffness, and high-sensitivity C-reactive protein (hsCRP), a biomarker of vascular inflammations, were measured during each examination. Two exposure assessment methods were used for estimating the subjects' exposure to PM2.5 and NO2. The first method involved constructing daily land use regression (LUR) models according to measurements collected at ambient air quality monitoring stations. The second method required combining the LUR estimates with indoor monitoring data at the workplace of the subjects. Linear mixed models were used to examine the association between the exposure estimates and health outcomes. The results showed that a 10-μg/m3 increase in PM2.5 concentration at a 1-day lag was associated with 2.1% (95% confidence interval: 0.7%–3.6%) and 2.4% (0.8%–4.0%) increases in baPWV based on the two exposure assessment methods, whereas no significant association was observed for NO2. The significant effects of PM2.5 remained in the two-pollutant models. By contrast, NO2, but not PM2.5, was significantly associated with increased hsCRP levels (16.0%–37.3% in single-pollutant models and 26.4%–44.6% in two-pollutant models, per 10-ppb increase in NO2). In conclusion, arterial stiffness might be more sensitive to short-term PM2.5 exposure than is inflammation.

AB - This study evaluated whether exposure to fine particulate matter (PM2.5) and nitrogen dioxide (NO2) is associated with cardiovascular effects by examining a panel of 89 healthy subjects in Taipei, Taiwan. The subjects received two health examinations approximately 8 months apart in 2013. Brachial–ankle pulse wave velocity (baPWV), a physiological indicator of arterial stiffness, and high-sensitivity C-reactive protein (hsCRP), a biomarker of vascular inflammations, were measured during each examination. Two exposure assessment methods were used for estimating the subjects' exposure to PM2.5 and NO2. The first method involved constructing daily land use regression (LUR) models according to measurements collected at ambient air quality monitoring stations. The second method required combining the LUR estimates with indoor monitoring data at the workplace of the subjects. Linear mixed models were used to examine the association between the exposure estimates and health outcomes. The results showed that a 10-μg/m3 increase in PM2.5 concentration at a 1-day lag was associated with 2.1% (95% confidence interval: 0.7%–3.6%) and 2.4% (0.8%–4.0%) increases in baPWV based on the two exposure assessment methods, whereas no significant association was observed for NO2. The significant effects of PM2.5 remained in the two-pollutant models. By contrast, NO2, but not PM2.5, was significantly associated with increased hsCRP levels (16.0%–37.3% in single-pollutant models and 26.4%–44.6% in two-pollutant models, per 10-ppb increase in NO2). In conclusion, arterial stiffness might be more sensitive to short-term PM2.5 exposure than is inflammation.

KW - Air pollution

KW - Arterial stiffness

KW - Cardiovascular

KW - Inflammation

KW - Land use regression

UR - http://www.scopus.com/inward/record.url?scp=84975885818&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975885818&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2016.06.084

DO - 10.1016/j.scitotenv.2016.06.084

M3 - Article

VL - 569-570

SP - 300

EP - 305

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -