Association of rhinosinusitis with nasopharyngeal carcinoma: A population-based study

Shih Han Hung, Po Yueh Chen, Herng Ching Lin, Jonathan Ting, Shiu Dong Chung

Research output: Contribution to journalArticle

21 Citations (Scopus)


Objectives/Hypothesis Although it is already known that the inflammation process elevates the risk of developing cancer, to date the association between rhinosinusitis and nasopharyngeal carcinoma (NPC) remains unknown. This study aimed to evaluate the association between rhinosinusitis and NPC based on a nationwide database. Study Design Case-control study. Methods In total, the cases comprised of 2,242 subjects with NPC and 6,726 randomly selected subjects as controls. Separate conditional logistic regression analyses were used to calculate the odds ratio (OR) for having been previously diagnosed with chronic and acute rhinosinusitis between the cases and controls. Results Of the total sample, 607subjects (6.77%) had been diagnosed with chronic rhinosinusitis prior to the index date: 322 (14.36%) cases with NPC and 285 (4.24%) controls (P

Original languageEnglish
Pages (from-to)1515-1520
Number of pages6
Issue number7
Publication statusPublished - 2014



  • nasopharyngeal carcinoma
  • Rhinosinusitis

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this