Association of reduced tumor necrosis factor alpha, gamma interferon, and interleukin-1β (IL-1β) but increased IL-10 expression with improved chest radiography in patients with pulmonary tuberculosis

Wen Lin Su, Wann Cherng Perng, Ching Hui Huang, Cheng Yu Yang, Chin Pyng Wu, Jenn Han Chen

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Mycobacterium tuberculosis infection is a major world health issue. The early identification of patients at risk for a poor response to anti-M. tuberculosis therapy would help elucidate the key players in the anti-M. tuberculosis response. The objective of the present study was to correlate the modulation of cytokine expression (interleukin-1 [IL-1], IL-6, IL-8, IL-10, IL-12, gamma interferon [IFN-γ], interferon-inducible protein [IP-10], and monocyte chemotactic protein 1 [MCP-1]) with the clinical response to 2 months of intensive therapy. From January to December 2007, 40 M. tuberculosis-infected patients and 40 healthy patients were recruited. After exclusion for diabetes, 32 patients and 36 controls were analyzed. The clinical responses of the M. tuberculosis-infected patients on the basis of the findings of chest radiography were compared to their plasma cytokine levels measured before and after 2 months of intensive anti-M. tuberculosis therapy and 6 months of therapy with human cytokine antibody arrays. Chest radiographs of 20 of 32 M. tuberculosis-infected patients showed improvement after 2 months of intensive therapy (early responders), while the M. tuberculosis infections in 12 of 32 of the patients resolved after a further 4 months (late responders). The levels of expression of TNF-α, MCP-1, IFN-γ, and IL-1β were decreased; and the level of IL-10 increased in early responders. After adjustment for age, gender, and the result of sputum culture for M. tuberculosis, significant differences in the levels of MCP-1 and IP-10 expression were observed between the early and the late responders after 2 months of intensive anti-M. tuberculosis therapy. Due to the interpatient variability in IP-10 levels, intrapatient monitoring of IP-10 levels may provide more insight into the M. tuberculosis responder status than comparison between patients. Plasma MCP-1 levels were normalized in patients who had resolved their M. tuberculosis infections. Further studies to evaluate the association of the modulation in MCP-1 levels with early and late responses are warranted.

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalClinical and Vaccine Immunology
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Chemokine CCL2
Radiography
Interleukin-1
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Interferon-alpha
Interleukin-10
Interferon-gamma
Thorax
Tumor Necrosis Factor-alpha
Cytokines
Mycobacterium Infections
Modulation
Plasmas
Interleukin-12
Medical problems
Interleukin-8
Interferons
Interleukin-6
Health

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Immunology
  • Immunology and Allergy
  • Microbiology (medical)

Cite this

Association of reduced tumor necrosis factor alpha, gamma interferon, and interleukin-1β (IL-1β) but increased IL-10 expression with improved chest radiography in patients with pulmonary tuberculosis. / Su, Wen Lin; Perng, Wann Cherng; Huang, Ching Hui; Yang, Cheng Yu; Wu, Chin Pyng; Chen, Jenn Han.

In: Clinical and Vaccine Immunology, Vol. 17, No. 2, 02.2010, p. 223-231.

Research output: Contribution to journalArticle

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