Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms

Ying Ju Lin, Yu Ching Lan, Chih Ho Lai, Ting Hsu Lin, Shao Mei Huang, Chiu Chu Liao, Cheng Wen Lin, Chien Hui Hung, Ni Tien, Xiang Liu, Wen Kuei Chien, Jin Hua Chen, Fuu Jen Tsai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients. Methods: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. Results: Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17–6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17–6.98). Conclusion: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalJournal of Clinical Laboratory Analysis
Volume28
Issue number6
DOIs
Publication statusPublished - Nov 1 2014
Externally publishedYes

Fingerprint

Coronary Aneurysm
Mucocutaneous Lymph Node Syndrome
Genetic Promoter Regions
Interleukin-10
Coronary Vessels
Polymorphism
Genetic Polymorphisms
Vasculitis
Taiwan
Gene Frequency
Haplotypes
Genes
Cytokines
Inflammation
Serum

Keywords

  • coronary artery aneurysms
  • genetic polymorphism
  • interleukin-10
  • Kawasaki disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

Cite this

Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms. / Lin, Ying Ju; Lan, Yu Ching; Lai, Chih Ho; Lin, Ting Hsu; Huang, Shao Mei; Liao, Chiu Chu; Lin, Cheng Wen; Hung, Chien Hui; Tien, Ni; Liu, Xiang; Chien, Wen Kuei; Chen, Jin Hua; Tsai, Fuu Jen.

In: Journal of Clinical Laboratory Analysis, Vol. 28, No. 6, 01.11.2014, p. 461-464.

Research output: Contribution to journalArticle

Lin, YJ, Lan, YC, Lai, CH, Lin, TH, Huang, SM, Liao, CC, Lin, CW, Hung, CH, Tien, N, Liu, X, Chien, WK, Chen, JH & Tsai, FJ 2014, 'Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms', Journal of Clinical Laboratory Analysis, vol. 28, no. 6, pp. 461-464. https://doi.org/10.1002/jcla.21710
Lin, Ying Ju ; Lan, Yu Ching ; Lai, Chih Ho ; Lin, Ting Hsu ; Huang, Shao Mei ; Liao, Chiu Chu ; Lin, Cheng Wen ; Hung, Chien Hui ; Tien, Ni ; Liu, Xiang ; Chien, Wen Kuei ; Chen, Jin Hua ; Tsai, Fuu Jen. / Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms. In: Journal of Clinical Laboratory Analysis. 2014 ; Vol. 28, No. 6. pp. 461-464.
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AU - Huang, Shao Mei

AU - Liao, Chiu Chu

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AB - Background: Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients. Methods: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. Results: Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17–6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17–6.98). Conclusion: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

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