Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms

Ying Ju Lin, Yu Ching Lan, Chih Ho Lai, Ting Hsu Lin, Shao Mei Huang, Chiu Chu Liao, Cheng Wen Lin, Chien Hui Hung, Ni Tien, Xiang Liu, Wen Kuei Chien, Jin Hua Chen, Fuu Jen Tsai

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12 Citations (Scopus)

Abstract

Background: Kawasaki disease (KD) is an acute, self-limited vasculitis in infants and young children. Interleukin-10 (IL-10) is a potent cytokine that exerts pleiotropic effects on immunoregulation and inflammation. Elevated IL-10 serum levels have been reported in the KD patients. Methods: In this study, we investigated whether IL-10 genetic polymorphisms contribute to coronary artery aneurysm (CAA) development among KD patients in Taiwan. A total of 58 KD patients with CAA and 277 unrelated healthy children matched for sex and age were enrolled for this study. Results: Higher G allele frequencies of IL-10 at -1082 position were observed in KD patients with CAA compared to the controls (P = 0.016, OR: 2.86, 95% CI, 1.17–6.98). In addition, higher IL-10 GCC haplotype frequencies were also observed in KD patients with CAA (P = 0.016, OR: 2.85, 95% CI, 1.17–6.98). Conclusion: Our data support the possibility that IL-10 gene polymorphisms may be related with CAA development of KD in Taiwanese population.

Original languageEnglish
Pages (from-to)461-464
Number of pages4
JournalJournal of Clinical Laboratory Analysis
Volume28
Issue number6
DOIs
Publication statusPublished - Nov 1 2014
Externally publishedYes

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Keywords

  • coronary artery aneurysms
  • genetic polymorphism
  • interleukin-10
  • Kawasaki disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology
  • Public Health, Environmental and Occupational Health
  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical
  • Microbiology (medical)

Cite this

Lin, Y. J., Lan, Y. C., Lai, C. H., Lin, T. H., Huang, S. M., Liao, C. C., Lin, C. W., Hung, C. H., Tien, N., Liu, X., Chien, W. K., Chen, J. H., & Tsai, F. J. (2014). Association of Promoter Genetic Variants in Interleukin-10 and Kawasaki Disease With Coronary Artery Aneurysms. Journal of Clinical Laboratory Analysis, 28(6), 461-464. https://doi.org/10.1002/jcla.21710