Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome

Te Fa Chiu; Chih Huang Li; Chun Chuan Chen; Chien Hsiun Chen; Chien Jui Cheng; Yu Ting Yan; Ruey Bing Yang

doi:10.1253/circj.CJ-12-0238

Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome

Te Fa Chiu, Chih Huang Li, Chun Chuan Chen, Chien Hsiun Chen, Chien Jui Cheng, Yu Ting Yan, Ruey Bing Yang

Department of Pathology

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P

Original language	English
Pages (from-to)	2226-2233
Number of pages	8
Journal	Circulation Journal
Volume	76
Issue number	9
DOIs	https://doi.org/10.1253/circj.CJ-12-0238
Publication status	Published - 2012

Keywords

Acute coronary syndrome
Biomarker
Myocardial infarction
Risk factors
Small heat shock protein

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Chiu, T. F., Li, C. H., Chen, C. C., Chen, C. H., Cheng, C. J., Yan, Y. T., & Yang, R. B. (2012). Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome. Circulation Journal, 76(9), 2226-2233. https://doi.org/10.1253/circj.CJ-12-0238

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abstract = "Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P",

keywords = "Acute coronary syndrome, Biomarker, Myocardial infarction, Risk factors, Small heat shock protein",

author = "Chiu, {Te Fa} and Li, {Chih Huang} and Chen, {Chun Chuan} and Chen, {Chien Hsiun} and Cheng, {Chien Jui} and Yan, {Yu Ting} and Yang, {Ruey Bing}",

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AU - Chiu, Te Fa

AU - Li, Chih Huang

AU - Chen, Chun Chuan

AU - Chen, Chien Hsiun

AU - Cheng, Chien Jui

AU - Yan, Yu Ting

AU - Yang, Ruey Bing

PY - 2012

Y1 - 2012

N2 - Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P

AB - Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P

KW - Acute coronary syndrome

KW - Biomarker

KW - Myocardial infarction

KW - Risk factors

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