Abstract
Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P
| Original language | English |
|---|---|
| Pages (from-to) | 2226-2233 |
| Number of pages | 8 |
| Journal | Circulation Journal |
| Volume | 76 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2012 |
Fingerprint
Keywords
- Acute coronary syndrome
- Biomarker
- Myocardial infarction
- Risk factors
- Small heat shock protein
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome. / Chiu, Te Fa; Li, Chih Huang; Chen, Chun Chuan; Chen, Chien Hsiun; Cheng, Chien Jui; Yan, Yu Ting; Yang, Ruey Bing.
In: Circulation Journal, Vol. 76, No. 9, 2012, p. 2226-2233.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of plasma concentration of small heat shock protein B7 with acute coronary syndrome
AU - Chiu, Te Fa
AU - Li, Chih Huang
AU - Chen, Chun Chuan
AU - Chen, Chien Hsiun
AU - Cheng, Chien Jui
AU - Yan, Yu Ting
AU - Yang, Ruey Bing
PY - 2012
Y1 - 2012
N2 - Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P
AB - Background: Heat shock proteins (HSPs) act as chaperones and have a protective function in cardiovascular diseases. The clinical association of a novel small HSPB7 with cardiovascular disease, however, has not been reported. The aim of this study was to investigate the potential biological functions of HSPB7 and its relationship with acute coronary syndrome (ACS). Methods and Results: A mouse myocardial infarction (MI) model and samples from clinical human subjects were used to determine plasma HSPB7 concentration after acute MI. The associations of plasma HSPB7 concentration with ACS and other risk factors of coronary artery disease were analyzed. Plasma HSPB7 concentration was found to be rapidly elevated in mice after coronary artery ligation. In addition, plasma HSPB7 concentration was significantly higher in patients with ACS than in control patients with non-cardiac chest pain (5.1 ng/ml vs. 2.9 ng/ml, P
KW - Acute coronary syndrome
KW - Biomarker
KW - Myocardial infarction
KW - Risk factors
KW - Small heat shock protein
UR - http://www.scopus.com/inward/record.url?scp=84865543506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865543506&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-12-0238
DO - 10.1253/circj.CJ-12-0238
M3 - Article
C2 - 22785082
AN - SCOPUS:84865543506
VL - 76
SP - 2226
EP - 2233
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 9
ER -