Association of physical performance and biochemical profile of mice with intrinsic endurance swimming

Wen Ching Huang, Yi Ju Hsu, Li Wei, Ying Ju Chen, Chi Chang Huang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We aimed to investigate the potential mediators and relationship affecting congenital exercise performance in an animal model with physical activity challenge from physiological and biochemical perspectives. A total of 75 male ICR mice (5 weeks old) were adapted for 1 week, then mice performed a non-loading and exhaustive swimming test and were assigned to 3 groups by exhaustive swimming time: low exercise capacity (LEC) (<3 hr), medium exercise capacity (MEC) (3-5 hr), and high exercise capacity (HEC) (>5 hr). After a 1-week rest, the 3 groups of mice performed an exhaustive swimming test with a 5% and 7.5% weight load and a forelimb grip-strength test, with a 1-week rest between tests. Blood samples were collected immediately after an acute exercise challenge and at the end of the experiment (resting status) to evaluate biochemical blood variables and their relation with physical performance. Physical activity, including exhaustive swimming and grip strength, was greater for HEC than other mice. The swimming performance and grip strength between groups were moderately correlated (r=0.443, p<0.05). Resting serum ammonium level was moderately correlated with endurance with a 7.5% weight load (r=-0.447, p<0.05) and with lactate level (r=0.598, p<0.05). The pulmonary morphology of the HEC group seemed to indicate benefits for aerobic exercise. Mice showed congenital exercise performance, which was significantly correlated with different physical challenges and biochemical variable values. This study may have implications for interference in intrinsic characteristics.

Original languageEnglish
Pages (from-to)892-901
Number of pages10
JournalInternational Journal of Medical Sciences
Volume13
Issue number12
DOIs
Publication statusPublished - Nov 2 2016

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Hand Strength
Exercise
Weights and Measures
Inbred ICR Mouse
Forelimb
Ammonium Compounds
Lactic Acid
Animal Models
Lung
Serum

Keywords

  • Ammonia
  • Congenital
  • Endurance swimming
  • Exercise performance
  • Forelimb grip

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of physical performance and biochemical profile of mice with intrinsic endurance swimming. / Huang, Wen Ching; Hsu, Yi Ju; Wei, Li; Chen, Ying Ju; Huang, Chi Chang.

In: International Journal of Medical Sciences, Vol. 13, No. 12, 02.11.2016, p. 892-901.

Research output: Contribution to journalArticle

Huang, Wen Ching ; Hsu, Yi Ju ; Wei, Li ; Chen, Ying Ju ; Huang, Chi Chang. / Association of physical performance and biochemical profile of mice with intrinsic endurance swimming. In: International Journal of Medical Sciences. 2016 ; Vol. 13, No. 12. pp. 892-901.
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