Association of pathobiologic determinants of atherosclerosis in youth risk score and carotid artery intima-media thickness in asymptomatic young heterozygous familial hypercholesterolemia patients

Hao Ming Cheng, Zhong Xuan Ye, Min Ji Charng

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Abstract

Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This study's aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 heterozygous FH patients (mean age 27) and 22 healthy control subjects (mean age 33). We computed the PDAY risk scores and measured the high-sensitive C-reactive protein (hsCRP) and carotid IMT. Results: In FH subjects, univariate analysis showed PDAY risk score was significant correlated with hsCRP and carotid IMT. Comparing FH subjects with the presence of carotid atheroma plaque (IMT > 1 mm) or without the plaque (IMT<1 mm), we found significantly higher PDAY risk score and hsCRP value in the presence group. By receiver operating characteristic curve, both hsCRP and PDAY risk score could predict the presence of carotid plaque. The multivariate analysis showed the correlation between PDAY risk score and carotid plaque (odds ratio for a 1-unit increase in the risk score was 1.161, 95% confidence interval: 1.027-1.312, p = 0.017). Conclusion: In young heterozygous FH subjects, PDAY risk score is strongly correlated with carotid IMT, and it might be a simple and useful tool for cardiovascular disease risk stratification in this population.

Original languageEnglish
Pages (from-to)152-157
Number of pages6
JournalActa Cardiologica Sinica
Volume27
Issue number3
Publication statusPublished - Sep 2011

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Carotid Intima-Media Thickness
Hyperlipoproteinemia Type II
Carotid Arteries
Atherosclerosis
C-Reactive Protein
Cardiovascular Diseases
Atherosclerotic Plaques
Hypercholesterolemia
ROC Curve
Population
Coronary Disease
Healthy Volunteers
Multivariate Analysis
Odds Ratio
Confidence Intervals
Inflammation

Keywords

  • C-reactive protein
  • Carotid intima-media thickness
  • Familial hypercholesterolemia
  • Pathobiologic determinants of atherosclerosis in youth risk score

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

@article{61909c0c865a4ddf88e45b10133cbcc8,
title = "Association of pathobiologic determinants of atherosclerosis in youth risk score and carotid artery intima-media thickness in asymptomatic young heterozygous familial hypercholesterolemia patients",
abstract = "Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This study's aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 heterozygous FH patients (mean age 27) and 22 healthy control subjects (mean age 33). We computed the PDAY risk scores and measured the high-sensitive C-reactive protein (hsCRP) and carotid IMT. Results: In FH subjects, univariate analysis showed PDAY risk score was significant correlated with hsCRP and carotid IMT. Comparing FH subjects with the presence of carotid atheroma plaque (IMT > 1 mm) or without the plaque (IMT<1 mm), we found significantly higher PDAY risk score and hsCRP value in the presence group. By receiver operating characteristic curve, both hsCRP and PDAY risk score could predict the presence of carotid plaque. The multivariate analysis showed the correlation between PDAY risk score and carotid plaque (odds ratio for a 1-unit increase in the risk score was 1.161, 95{\%} confidence interval: 1.027-1.312, p = 0.017). Conclusion: In young heterozygous FH subjects, PDAY risk score is strongly correlated with carotid IMT, and it might be a simple and useful tool for cardiovascular disease risk stratification in this population.",
keywords = "C-reactive protein, Carotid intima-media thickness, Familial hypercholesterolemia, Pathobiologic determinants of atherosclerosis in youth risk score",
author = "Cheng, {Hao Ming} and Ye, {Zhong Xuan} and Charng, {Min Ji}",
year = "2011",
month = "9",
language = "English",
volume = "27",
pages = "152--157",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
publisher = "Republic of China Society of Cardiology",
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T1 - Association of pathobiologic determinants of atherosclerosis in youth risk score and carotid artery intima-media thickness in asymptomatic young heterozygous familial hypercholesterolemia patients

AU - Cheng, Hao Ming

AU - Ye, Zhong Xuan

AU - Charng, Min Ji

PY - 2011/9

Y1 - 2011/9

N2 - Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This study's aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 heterozygous FH patients (mean age 27) and 22 healthy control subjects (mean age 33). We computed the PDAY risk scores and measured the high-sensitive C-reactive protein (hsCRP) and carotid IMT. Results: In FH subjects, univariate analysis showed PDAY risk score was significant correlated with hsCRP and carotid IMT. Comparing FH subjects with the presence of carotid atheroma plaque (IMT > 1 mm) or without the plaque (IMT<1 mm), we found significantly higher PDAY risk score and hsCRP value in the presence group. By receiver operating characteristic curve, both hsCRP and PDAY risk score could predict the presence of carotid plaque. The multivariate analysis showed the correlation between PDAY risk score and carotid plaque (odds ratio for a 1-unit increase in the risk score was 1.161, 95% confidence interval: 1.027-1.312, p = 0.017). Conclusion: In young heterozygous FH subjects, PDAY risk score is strongly correlated with carotid IMT, and it might be a simple and useful tool for cardiovascular disease risk stratification in this population.

AB - Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by extremely high cholesterol level, accelerated atherosclerosis and premature cardiovascular disease.We need an early risk stratification method for this population. Arisk score formula to estimate the probability of advanced atherosclerosis using coronary heart disease risk factors was developed for persons 15-34 years of age by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. This study's aim was to investigate the relation between PDAY risk score and carotid intima-media thickness (IMT) and inflammation markers in asymptomatic young FH subjects. Methods: We included 23 heterozygous FH patients (mean age 27) and 22 healthy control subjects (mean age 33). We computed the PDAY risk scores and measured the high-sensitive C-reactive protein (hsCRP) and carotid IMT. Results: In FH subjects, univariate analysis showed PDAY risk score was significant correlated with hsCRP and carotid IMT. Comparing FH subjects with the presence of carotid atheroma plaque (IMT > 1 mm) or without the plaque (IMT<1 mm), we found significantly higher PDAY risk score and hsCRP value in the presence group. By receiver operating characteristic curve, both hsCRP and PDAY risk score could predict the presence of carotid plaque. The multivariate analysis showed the correlation between PDAY risk score and carotid plaque (odds ratio for a 1-unit increase in the risk score was 1.161, 95% confidence interval: 1.027-1.312, p = 0.017). Conclusion: In young heterozygous FH subjects, PDAY risk score is strongly correlated with carotid IMT, and it might be a simple and useful tool for cardiovascular disease risk stratification in this population.

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