Association of Novel Gene Polymorphisms RRM1 -756T>C and -269 C>A With Breast Cancer

Dar Ren Chen, Chun Yi Chuang, Buor Chang Wu, Shun Fa Yang, Yu Hsien Peng, Hsiu Ting Tsai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Genetic variants are reported to play an important role in the susceptibility of breast cancer. Ribonucleotide reductase 1 (RRM1) is suggested to play an essential role in the regulation of cancer development. The purpose of this study was to identify novel gene polymorphisms of RRM1 -756T>C and RRM1 -269 C>A specific to patients with breast cancer and healthy controls. Methods: A total of 833 subjects, including 321 healthy controls and 512 patients with breast cancer, were recruited in this study. Allelic discrimination of RRM1 -756T>C (rs11030919) and RRM1 -269C>A (rs12806698) polymorphisms of the RRM1 gene was assessed with the real-time polymerase chain reaction. Results: The adjusted odds ratios and 95% confidence intervals were 1.20 (0.71-2.04) and 1.10 (0.65-1.86) to have breast cancer among individuals with CC alleles of RRM1 -756T>C and individuals with AA alleles of RRM1 -269C>A gene polymorphism, respectively, compared to individuals having wild type of RRM1 gene polymorphisms. Also, there was no significant genetic interaction effect on the susceptibility of breast cancer and nonassociation between genetic polymorphisms and clinical statuses of breast cancer. Conclusion: Gene polymorphisms of RRM1 -756T>C and RRM1 -269C>A may be not an important factor for the susceptibility of breast cancer.

Original languageEnglish
Pages (from-to)287-293
Number of pages7
JournalJournal of Clinical Laboratory Analysis
Volume28
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Polymorphism
Genes
Breast Neoplasms
Ribonucleotide Reductases
Alleles
Polymerase chain reaction
Genetic Polymorphisms
Real-Time Polymerase Chain Reaction
Odds Ratio
Confidence Intervals
Neoplasms

Keywords

  • Breast cancer
  • Ribonucleotide reductase 1
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Public Health, Environmental and Occupational Health
  • Hematology
  • Immunology and Allergy
  • Microbiology (medical)
  • Medical Laboratory Technology
  • Medicine(all)

Cite this

Association of Novel Gene Polymorphisms RRM1 -756T>C and -269 C>A With Breast Cancer. / Chen, Dar Ren; Chuang, Chun Yi; Wu, Buor Chang; Yang, Shun Fa; Peng, Yu Hsien; Tsai, Hsiu Ting.

In: Journal of Clinical Laboratory Analysis, Vol. 28, No. 4, 2014, p. 287-293.

Research output: Contribution to journalArticle

Chen, Dar Ren ; Chuang, Chun Yi ; Wu, Buor Chang ; Yang, Shun Fa ; Peng, Yu Hsien ; Tsai, Hsiu Ting. / Association of Novel Gene Polymorphisms RRM1 -756T>C and -269 C>A With Breast Cancer. In: Journal of Clinical Laboratory Analysis. 2014 ; Vol. 28, No. 4. pp. 287-293.
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AB - Background: Genetic variants are reported to play an important role in the susceptibility of breast cancer. Ribonucleotide reductase 1 (RRM1) is suggested to play an essential role in the regulation of cancer development. The purpose of this study was to identify novel gene polymorphisms of RRM1 -756T>C and RRM1 -269 C>A specific to patients with breast cancer and healthy controls. Methods: A total of 833 subjects, including 321 healthy controls and 512 patients with breast cancer, were recruited in this study. Allelic discrimination of RRM1 -756T>C (rs11030919) and RRM1 -269C>A (rs12806698) polymorphisms of the RRM1 gene was assessed with the real-time polymerase chain reaction. Results: The adjusted odds ratios and 95% confidence intervals were 1.20 (0.71-2.04) and 1.10 (0.65-1.86) to have breast cancer among individuals with CC alleles of RRM1 -756T>C and individuals with AA alleles of RRM1 -269C>A gene polymorphism, respectively, compared to individuals having wild type of RRM1 gene polymorphisms. Also, there was no significant genetic interaction effect on the susceptibility of breast cancer and nonassociation between genetic polymorphisms and clinical statuses of breast cancer. Conclusion: Gene polymorphisms of RRM1 -756T>C and RRM1 -269C>A may be not an important factor for the susceptibility of breast cancer.

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