Association of monoamine oxidase A alleles with alcoholism among male Chinese in Taiwan

Yun Pung P. Hsu, El W. Loh, Wei J. Chen, Chiao Chicy Chen, Jeng Ming Yu, Andrew T.A. Cheng

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Objective: The role of monoamine oxidase (MAO) in alcoholism was assessed by genetic association studies separately in five ethnic groups in Taiwan. Method: Restriction fragment length polymorphisms (RHLP) and dinucleotide repeat polymorphisms (DNRP) were used to determine MAOA and MAOB alleles in male alcoholic patients and nonalcoholic comparison subjects among Han Chinese and four aboriginal groups. Results: Significant associations of alcohol dependence with MAOA alleles (RFLP and DNRP) were found among the Han Chinese, but not among the aboriginal groups. No significant association with MAOB DNRP alleles was found in any group. Conclusions: Genetic heterogeneity may underlie alcoholism among different ethnic groups in Taiwan, and MAOA mutations may play a role in susceptibility to alcoholism among Han Chinese.

Original languageEnglish
Pages (from-to)1209-1211
Number of pages3
JournalAmerican Journal of Psychiatry
Volume153
Issue number9
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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