Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk

Ming Hsien Wu, Huey En Tzeng, Cheng Nan Wu, Te Cheng Yueh, Yen Chun Peng, Chun Hao Tsai, Yun Chi Wang, Tao Wei Ke, Jen Sheng Pei, Wen Shin Chang, Chia Wen Tsai, Da Tian Bau

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4 Citations (Scopus)

Abstract

Background/Aim: Matrix metalloproteinase-9 (MMP-9) is responsible for modifying extracellular components and plays a crucial role in the metastatic behavior of cancer. This study aimed at examining the role of MMP-9 rs3918242 genotypes on colorectal cancer (CRC) risk. Materials and Methods: A total of 362 CRC patients and 362 healthy subjects in Taiwan, were examined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: The MMP-9 rs3918242 TT genotype carriers had a slightly increased risk of CRC compared to CC carriers (p=0.1642, OR=1.88, 95% CI=0.84-4.16). Patients of CT/TT genotypes were on significantly higher risk of metastasis (p=0.0027) than those of CC genotype. No obvious association was found between MMP-9 genotype and CRC risk among ever-smokers, non-smokers, non-alcohol drinkers or alcohol drinkers. No significant correlation was observed between MMP-9 genotypic distributions with age, gender, tumor size or location. Conclusion: MMP-9 rs3918242 genotypes may interact with BMI to serve as a predictor for higher CRC risk, and independently as a predictor for metastasis.

Original languageEnglish
Pages (from-to)6523-6529
Number of pages7
JournalAnticancer Research
Volume39
Issue number12
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Case-control study
  • Colorectal cancer
  • Genotype
  • MMP-9
  • Polymorphism
  • Taiwan

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Wu, M. H., Tzeng, H. E., Wu, C. N., Yueh, T. C., Peng, Y. C., Tsai, C. H., Wang, Y. C., Ke, T. W., Pei, J. S., Chang, W. S., Tsai, C. W., & Bau, D. T. (2019). Association of matrix Metalloproteinase-9 rs3918242 promoter genotypes with colorectal cancer risk. Anticancer Research, 39(12), 6523-6529. https://doi.org/10.21873/anticanres.13867