Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

Kuang Chi Lai, Wei Yong Lin, Kee Ming Man, Chou Haung Tsai, Huey Yi Chen, Fuu Jen Tsai, Fun Jou Chen, Hsin Yi Chen, Hsin Ping Liu, Tsung Jung Ho, Po Hsun Huang, Po Len Liu, Feng Yen Lin, Jui Lung Shen, Jung Tung Liu, Yung Hsiang Chen, Wen Chi Chen

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Abstract

Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at 607C/A, 137G/C and 105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 105A/C polymorphism. The prevalence of the A/C C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 105A/C associated with urolithiasis was 2.772. The OR of the A/C C/C genotypes of IL-18 105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 105A/C polymorphisms may play a role in the development of urolithiasis.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
JournalScandinavian Journal of Urology and Nephrology
Volume44
Issue number1
DOIs
Publication statusPublished - 2010

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Keywords

  • Calcium oxalate
  • Interleukin-18 gene
  • Single-nucleotide polymorphisms
  • Urolithiasis

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Lai, K. C., Lin, W. Y., Man, K. M., Tsai, C. H., Chen, H. Y., Tsai, F. J., Chen, F. J., Chen, H. Y., Liu, H. P., Ho, T. J., Huang, P. H., Liu, P. L., Lin, F. Y., Shen, J. L., Liu, J. T., Chen, Y. H., & Chen, W. C. (2010). Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease. Scandinavian Journal of Urology and Nephrology, 44(1), 20-26. https://doi.org/10.3109/00365590903449332