Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

Kuang Chi Lai; Wei Yong Lin; Kee Ming Man; Chou Haung Tsai; Huey Yi Chen; Fuu Jen Tsai; Fun Jou Chen; Hsin Yi Chen; Hsin Ping Liu; Tsung Jung Ho; Po Hsun Huang; Po Len Liu; Feng Yen Lin; Jui Lung Shen; Jung Tung Liu; Yung Hsiang Chen; Wen Chi Chen

doi:10.3109/00365590903449332

Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

Kuang Chi Lai, Wei Yong Lin, Kee Ming Man, Chou Haung Tsai, Huey Yi Chen, Fuu Jen Tsai, Fun Jou Chen, Hsin Yi Chen, Hsin Ping Liu, Tsung Jung Ho, Po Hsun Huang, Po Len Liu, Feng Yen Lin, Jui Lung Shen, Jung Tung Liu, Yung Hsiang Chen, Wen Chi Chen

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at 607C/A, 137G/C and 105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 105A/C polymorphism. The prevalence of the A/C C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 105A/C associated with urolithiasis was 2.772. The OR of the A/C C/C genotypes of IL-18 105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 105A/C polymorphisms may play a role in the development of urolithiasis.

Original language	English
Pages (from-to)	20-26
Number of pages	7
Journal	Scandinavian Journal of Urology and Nephrology
Volume	44
Issue number	1
DOIs	https://doi.org/10.3109/00365590903449332
Publication status	Published - 2010

Keywords

Calcium oxalate
Interleukin-18 gene
Single-nucleotide polymorphisms
Urolithiasis

ASJC Scopus subject areas

Nephrology
Urology

Access to Document

10.3109/00365590903449332

Cite this

Lai, K. C., Lin, W. Y., Man, K. M., Tsai, C. H., Chen, H. Y., Tsai, F. J., Chen, F. J., Chen, H. Y., Liu, H. P., Ho, T. J., Huang, P. H., Liu, P. L., Lin, F. Y., Shen, J. L., Liu, J. T., Chen, Y. H., & Chen, W. C. (2010). Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease. Scandinavian Journal of Urology and Nephrology, 44(1), 20-26. https://doi.org/10.3109/00365590903449332

Lai, KC, Lin, WY, Man, KM, Tsai, CH, Chen, HY, Tsai, FJ, Chen, FJ, Chen, HY, Liu, HP, Ho, TJ, Huang, PH, Liu, PL, Lin, FY, Shen, JL, Liu, JT, Chen, YH & Chen, WC 2010, 'Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease', Scandinavian Journal of Urology and Nephrology, vol. 44, no. 1, pp. 20-26. https://doi.org/10.3109/00365590903449332

@article{9c55d2c261c94874b5649bbf2c534ee4,

title = "Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease",

abstract = "Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at 607C/A, 137G/C and 105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 105A/C polymorphism. The prevalence of the A/C C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 105A/C associated with urolithiasis was 2.772. The OR of the A/C C/C genotypes of IL-18 105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 105A/C polymorphisms may play a role in the development of urolithiasis.",

keywords = "Calcium oxalate, Interleukin-18 gene, Single-nucleotide polymorphisms, Urolithiasis",

author = "Lai, {Kuang Chi} and Lin, {Wei Yong} and Man, {Kee Ming} and Tsai, {Chou Haung} and Chen, {Huey Yi} and Tsai, {Fuu Jen} and Chen, {Fun Jou} and Chen, {Hsin Yi} and Liu, {Hsin Ping} and Ho, {Tsung Jung} and Huang, {Po Hsun} and Liu, {Po Len} and Lin, {Feng Yen} and Shen, {Jui Lung} and Liu, {Jung Tung} and Chen, {Yung Hsiang} and Chen, {Wen Chi}",

note = "Funding Information: This work was supported by grants NSC 97-2320-B-039-022-MY3 and NSC 98-2314-B-039-023-MY3 from the National Science Council, Taiwan, and grants CMU97-CMC-003, CMU97-279 and DMR-98-105 from the Center for Inflammation Research (CMU98-CT-10), China Medical University and Hospital, Taichung, Taiwan. The authors thank Miss Yi-Chun Chang, Chiao-Hui Chang and Ching-Yi Lu for manuscript preparation.",

year = "2010",

doi = "10.3109/00365590903449332",

language = "English",

volume = "44",

pages = "20--26",

journal = "Scandinavian Journal of Urology",

issn = "2168-1805",

publisher = "Informa Healthcare",

number = "1",

}

TY - JOUR

T1 - Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

AU - Lai, Kuang Chi

AU - Lin, Wei Yong

AU - Man, Kee Ming

AU - Tsai, Chou Haung

AU - Chen, Huey Yi

AU - Tsai, Fuu Jen

AU - Chen, Fun Jou

AU - Chen, Hsin Yi

AU - Liu, Hsin Ping

AU - Ho, Tsung Jung

AU - Huang, Po Hsun

AU - Liu, Po Len

AU - Lin, Feng Yen

AU - Shen, Jui Lung

AU - Liu, Jung Tung

AU - Chen, Yung Hsiang

AU - Chen, Wen Chi

N1 - Funding Information: This work was supported by grants NSC 97-2320-B-039-022-MY3 and NSC 98-2314-B-039-023-MY3 from the National Science Council, Taiwan, and grants CMU97-CMC-003, CMU97-279 and DMR-98-105 from the Center for Inflammation Research (CMU98-CT-10), China Medical University and Hospital, Taichung, Taiwan. The authors thank Miss Yi-Chun Chang, Chiao-Hui Chang and Ching-Yi Lu for manuscript preparation.

PY - 2010

Y1 - 2010

N2 - Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at 607C/A, 137G/C and 105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 105A/C polymorphism. The prevalence of the A/C C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 105A/C associated with urolithiasis was 2.772. The OR of the A/C C/C genotypes of IL-18 105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 105A/C polymorphisms may play a role in the development of urolithiasis.

AB - Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at 607C/A, 137G/C and 105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 105A/C polymorphism. The prevalence of the A/C C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 105A/C associated with urolithiasis was 2.772. The OR of the A/C C/C genotypes of IL-18 105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 105A/C polymorphisms may play a role in the development of urolithiasis.

KW - Calcium oxalate

KW - Interleukin-18 gene

KW - Single-nucleotide polymorphisms

KW - Urolithiasis

UR - http://www.scopus.com/inward/record.url?scp=76749163285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=76749163285&partnerID=8YFLogxK

U2 - 10.3109/00365590903449332

DO - 10.3109/00365590903449332

M3 - Article

C2 - 20017708

AN - SCOPUS:76749163285

VL - 44

SP - 20

EP - 26

JO - Scandinavian Journal of Urology

JF - Scandinavian Journal of Urology

SN - 2168-1805

IS - 1

ER -

Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this