Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan

Ying Ju Lin, Wen Ling Liao, Chung Hsing Wang, Li Ping Tsai, Chih Hsin Tang, Chien Hsiun Chen, Jer Yuarn Wu, Wen Miin Liang, Ai Ru Hsieh, Chi Fung Cheng, Jin Hua Chen, Wen Kuei Chien, Ting Hsu Lin, Chia Ming Wu, Chiu Chu Liao, Shao Mei Huang, Fuu Jen Tsai

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Abstract

Human height can be described as a classical and inherited trait model. Genome-wide association studies (GWAS) have revealed susceptible loci and provided insights into the polygenic nature of human height. Familial short stature (FSS) represents a suitable trait for investigating short stature genetics because disease associations with short stature have been ruled out in this case. In addition, FSS is caused only by genetically inherited factors. In this study, we explored the correlations of FSS risk with the genetic loci associated with human height in previous GWAS, alone and cumulatively. We systematically evaluated 34 known human height single nucleotide polymorphisms (SNPs) in relation to FSS in the additive model (p < 0.00005). A cumulative effect was observed: the odds ratios gradually increased with increasing genetic risk score quartiles (p < 0.001; Cochran-Armitage trend test). Six affected genes - ZBTB38, ZNF638, LCORL, CABLES1, CDK10, and TSEN15 - are located in the nucleus and have been implicated in embryonic, organismal, and tissue development. In conclusion, our study suggests that 13 human height GWAS-identified SNPs are associated with FSS risk both alone and cumulatively.

Original languageEnglish
Article number6372
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Taiwan
Genome-Wide Association Study
Single Nucleotide Polymorphism
Inborn Genetic Diseases
Genetic Loci
Human Genome
Odds Ratio
Genes

ASJC Scopus subject areas

  • General

Cite this

Lin, Y. J., Liao, W. L., Wang, C. H., Tsai, L. P., Tang, C. H., Chen, C. H., ... Tsai, F. J. (2017). Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan. Scientific Reports, 7(1), [6372]. https://doi.org/10.1038/s41598-017-06766-z

Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan. / Lin, Ying Ju; Liao, Wen Ling; Wang, Chung Hsing; Tsai, Li Ping; Tang, Chih Hsin; Chen, Chien Hsiun; Wu, Jer Yuarn; Liang, Wen Miin; Hsieh, Ai Ru; Cheng, Chi Fung; Chen, Jin Hua; Chien, Wen Kuei; Lin, Ting Hsu; Wu, Chia Ming; Liao, Chiu Chu; Huang, Shao Mei; Tsai, Fuu Jen.

In: Scientific Reports, Vol. 7, No. 1, 6372, 01.12.2017.

Research output: Contribution to journalArticle

Lin, YJ, Liao, WL, Wang, CH, Tsai, LP, Tang, CH, Chen, CH, Wu, JY, Liang, WM, Hsieh, AR, Cheng, CF, Chen, JH, Chien, WK, Lin, TH, Wu, CM, Liao, CC, Huang, SM & Tsai, FJ 2017, 'Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan', Scientific Reports, vol. 7, no. 1, 6372. https://doi.org/10.1038/s41598-017-06766-z
Lin, Ying Ju ; Liao, Wen Ling ; Wang, Chung Hsing ; Tsai, Li Ping ; Tang, Chih Hsin ; Chen, Chien Hsiun ; Wu, Jer Yuarn ; Liang, Wen Miin ; Hsieh, Ai Ru ; Cheng, Chi Fung ; Chen, Jin Hua ; Chien, Wen Kuei ; Lin, Ting Hsu ; Wu, Chia Ming ; Liao, Chiu Chu ; Huang, Shao Mei ; Tsai, Fuu Jen. / Association of human height-related genetic variants with familial short stature in Han Chinese in Taiwan. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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