Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan

Hong Yuan Hsu, Mei Hwei Chang, Hong Nerng Ho, Rhong Phong Hsieh, Shyh Dye Lee, Ding Shinn Chen, Chin Yun Lee, Kue Hsiung Hsieh

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36 Citations (Scopus)

Abstract

To determine the HLA-linked immune response gene that controls low responsiveness to hepatitis B surface antigen (HBsAg), HLA typing was performed in 33 initial non-responders (male:female = 23:10, age 1.5-46 years) who had poor antibody response (anti-HBs < 10 mIU ml-1) after four doses of plasma-derived hepatitis B vaccine. Of 33 initial non-responders, 26 received two additional doses of either the same vaccine (n = 18) or recombinant hepatitis B vaccine (n = 8) and returned for anti-HBs measurement. At 1 month after the sixth dose, anti-HBs was still <10 mIU ml-1 in 20 cases and 10-20 mIU ml-1 in three cases. Analysis of HLA antigen frequencies in these 23 ultimate low responders revealed that nine (39%) were positive for DR14, a statistically significant association of low responsiveness to hepatitis B vaccine with HLA-DR14. In addition, 26% of the ultimate low-responders were positive for DQ3, a frequency significantly lower than the expected rate in the general population. Among the nine ultimate low-responders with DR14, seven were heterozygous for this allele, while the other two cases had a single isolated DR14; and all nine were in association with DR52. These results suggest that a DR14-DR52 association, probably dominantly expressed, may be involved in the low immune responsiveness to hepatitis B vaccine of the Chinese population in Taiwan.

Original languageEnglish
Pages (from-to)1437-1440
Number of pages4
JournalVaccine
Volume11
Issue number14
DOIs
Publication statusPublished - Jan 1 1993
Externally publishedYes

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Keywords

  • hepatitis B vaccine
  • HLA
  • non-responder

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Hsu, H. Y., Chang, M. H., Ho, H. N., Hsieh, R. P., Lee, S. D., Chen, D. S., Lee, C. Y., & Hsieh, K. H. (1993). Association of HLA-DR14-DR52 with low responsiveness to hepatitis B vaccine in Chinese residents in Taiwan. Vaccine, 11(14), 1437-1440. https://doi.org/10.1016/0264-410X(93)90173-U