Association of high body lead store with severe intracranial carotid atherosclerosis

Tsong Hai Lee, Mei Chun Tseng, Chi Jen Chen, Ja Liang Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Lead is involved in the pathogenesis of atherosclerosis and hypertensive disease and may be related to cerebrovascular disease. We studied the association of body lead level with stroke subtypes and severity of cerebral atherosclerosis in order to identify the significance of lead exposure to cerebrovascular disease. Methods: From April, 2002 to March, 2005, we studied the lead level in all patients receiving digital subtraction angiography. Diameter stenosis at extracranial carotid, intracranial carotid and vertebrobasilar system was calculated according to the NASCET criteria. A blood sample and a mobilization test of 72-h urine sample were collected for lead measurement. Results: In a total of 213 subjects, 19 were free of stroke (blood lead level = 4.62 ± 2.41 μg/dL, body lead store = 39.04 ± 20.91 μg) and 194 were stroke patients (4.89 ± 2.75 μg/dL, 45.13 ± 29.8 μg; all stroke vs. non-stroke, P > 0.05). In the 153 subjects with atherosclerotic origin, body lead store but not blood lead level in the intracranial carotid system was significantly higher in ≥50% group than 0.05). Conclusion: Our study demonstrated that long-term lead exposure as measured by body lead store might carry a potential risk of intracranial carotid atherosclerosis.

Original languageEnglish
Pages (from-to)876-880
Number of pages5
JournalNeuroToxicology
Volume30
Issue number6
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Angiography
  • Atherosclerosis
  • Carotid artery
  • Lead
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Toxicology

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