Association of hepatitis c virus infection with risk of ESRD

A population-based study

Fu Hsiung Su, Chien Tien Su, Shih Ni Chang, Pei Chun Chen, Fung Chang Sung, Cheng Chieh Lin, Chih Ching Yeh

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background: The association between chronic hepatitis C virus (HCV) infection and end-stage renal disease (ESRD) has been widely debated. Study Design: National population-based cohort study. Setting & Participants: Insurance claims data from the Taiwan National Health Insurance Research Database in 2000-2005. Predictor: Chronic HCV infection as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Outcomes: ESRD as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Results: We identified 6,291 adults with chronic HCV infection. The control group included 31,455 sex- and age-matched individuals without evidence of chronic hepatitis. The incidence of ESRD was 2.14-fold higher in patients with chronic HCV infection (HR, 1.53; 95% CI, 1.17-2.01; P = 0.002) than in patients without HCV infection. Age stratification analysis showed that patients aged 50-59 years with chronic HCV infection (HR, 7.77; 95% CI, 4.23-14.3; P <0.001) had the highest risk of developing ESRD relative to patients aged 20-49 years without chronic HCV infection (interaction P <0.001). Limitations: Lack of clinical data. Conclusions: Patients with chronic HCV infection are at greater risk of developing ESRD than individuals without chronic HCV infection. In addition, the risk of developing ESRD is highest in younger patients with HCV infection. Early renal screening programs should be initiated for this high-risk group of young individuals with chronic HCV infection.

Original languageEnglish
Pages (from-to)553-560
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume60
Issue number4
DOIs
Publication statusPublished - Oct 2012

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Hepatitis Viruses
Virus Diseases
Hepacivirus
Chronic Kidney Failure
Chronic Hepatitis C
Population
International Classification of Diseases
National Health Programs
Chronic Hepatitis
Insurance
Taiwan
Cohort Studies
Databases

Keywords

  • end-stage renal disease
  • Hepatitis C virus

ASJC Scopus subject areas

  • Nephrology

Cite this

Association of hepatitis c virus infection with risk of ESRD : A population-based study. / Su, Fu Hsiung; Su, Chien Tien; Chang, Shih Ni; Chen, Pei Chun; Sung, Fung Chang; Lin, Cheng Chieh; Yeh, Chih Ching.

In: American Journal of Kidney Diseases, Vol. 60, No. 4, 10.2012, p. 553-560.

Research output: Contribution to journalArticle

Su, Fu Hsiung ; Su, Chien Tien ; Chang, Shih Ni ; Chen, Pei Chun ; Sung, Fung Chang ; Lin, Cheng Chieh ; Yeh, Chih Ching. / Association of hepatitis c virus infection with risk of ESRD : A population-based study. In: American Journal of Kidney Diseases. 2012 ; Vol. 60, No. 4. pp. 553-560.
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abstract = "Background: The association between chronic hepatitis C virus (HCV) infection and end-stage renal disease (ESRD) has been widely debated. Study Design: National population-based cohort study. Setting & Participants: Insurance claims data from the Taiwan National Health Insurance Research Database in 2000-2005. Predictor: Chronic HCV infection as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Outcomes: ESRD as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification. Results: We identified 6,291 adults with chronic HCV infection. The control group included 31,455 sex- and age-matched individuals without evidence of chronic hepatitis. The incidence of ESRD was 2.14-fold higher in patients with chronic HCV infection (HR, 1.53; 95{\%} CI, 1.17-2.01; P = 0.002) than in patients without HCV infection. Age stratification analysis showed that patients aged 50-59 years with chronic HCV infection (HR, 7.77; 95{\%} CI, 4.23-14.3; P <0.001) had the highest risk of developing ESRD relative to patients aged 20-49 years without chronic HCV infection (interaction P <0.001). Limitations: Lack of clinical data. Conclusions: Patients with chronic HCV infection are at greater risk of developing ESRD than individuals without chronic HCV infection. In addition, the risk of developing ESRD is highest in younger patients with HCV infection. Early renal screening programs should be initiated for this high-risk group of young individuals with chronic HCV infection.",
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