Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals

Meei Maan Wu, Hung Yi Chiou, Chi Ling Chen, Ling I. Hsu, Li Ming Lien, Chih Hao Wang, Yi Chen Hsieh, Yuan Hung Wang, Yu Mei Hsueh, Te Chang Lee, Wen Fang Cheng, Chien Jen Chen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: Heme oxygenase (HO)-1 is up-regulated as a cellular defense responding to stressful stimuli in experimental studies. A GT-repeat length polymorphism in the HO-1 gene promoter was inversely correlated to HO-1 induction. Here, we reported the association of GT-repeat polymorphism with blood pressure (BP) phenotypes, and their interaction on cardiovascular (CV) mortality risk in arsenic-exposed cohorts. Methods: Associations of GT-repeat polymorphism with BP phenotypes were investigated at baseline in a cross-sectional design. Effect of GT-repeat polymorphism on CV mortality was investigated in a longitudinal design stratified by hypertension. GT-repeat variants were grouped by S (

Original languageEnglish
Pages (from-to)704-708
Number of pages5
JournalAtherosclerosis
Volume219
Issue number2
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Blood pressure
  • Cardiovascular mortality
  • Genetic polymorphism
  • Heme oxygenase-1
  • Population study
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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