Association of fungal colonization and invasive disease in very low birth weight infants

Yhu Chering Huang, Chung Chen Li, Tzou Yien Lin, Rey In Lien, Yi Hong Chou, Jue Lan Wu, Chuen Hsueh

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Background. Fungi are common pathogens of nosocomial infections in the very low birth weight (VLBW) infants. The purpose of this study was to investigate the fungal colonization rate in VLBW infants and the association between fungal colonization and systemic fungal diseases. Materials. Between January 1, 1996, and December 31, 1996, 116 infants with birth weight <1500 g admitted to the neonatal intensive care unit of Chang Gung Children's Hospital in the first day of life were included in this prospective study. Methods. Cultures from oropharynx, rectum, skin (groin and axilla), bag urine and endotracheal aspirates were obtained in the first 24 h after birth and weekly thereafter throughout their neonatal intensive care unit stay. Medical records were reviewed weekly. Results. Fungal colonization was detected in 25 infants, among whom 17 infants developed colonization by 2 weeks of life. Candida albicans (61%) and Candida parapsilosis (29%) were the 2 most common organisms. The rectum (76%) was the most frequent site of colonization. Factors significantly associated with colonization were prolonged administration of antibiotic therapy, parenteral nutrition and intralipid emulsion. Three of 116 infants developed fungemia. The association between colonization and subsequent fungemia was demonstrated in 1 infant, representing 4% of colonized infants. Conclusion. Fungal colonization was detected in one-fifth of VLBW infants and represents a risk factor for fungemia. Because disease occurred in the absence of apparent colonization, factors other than colonization may contribute to invasive candidiasis.

Original languageEnglish
Pages (from-to)819-822
Number of pages4
JournalPediatric Infectious Disease Journal
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 1998
Externally publishedYes

Fingerprint

Very Low Birth Weight Infant
Fungemia
Neonatal Intensive Care Units
Rectum
Invasive Candidiasis
Oropharynx
Axilla
Mycoses
Groin
Parenteral Nutrition
Cross Infection
Emulsions
Candida albicans
Candida
Birth Weight
Medical Records
Fungi
Urine
Parturition
Prospective Studies

Keywords

  • Fungal colonization
  • Invasive candidiasis
  • Very low birth weight infants

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Association of fungal colonization and invasive disease in very low birth weight infants. / Huang, Yhu Chering; Li, Chung Chen; Lin, Tzou Yien; Lien, Rey In; Chou, Yi Hong; Wu, Jue Lan; Hsueh, Chuen.

In: Pediatric Infectious Disease Journal, Vol. 17, No. 9, 09.1998, p. 819-822.

Research output: Contribution to journalArticle

Huang, Yhu Chering ; Li, Chung Chen ; Lin, Tzou Yien ; Lien, Rey In ; Chou, Yi Hong ; Wu, Jue Lan ; Hsueh, Chuen. / Association of fungal colonization and invasive disease in very low birth weight infants. In: Pediatric Infectious Disease Journal. 1998 ; Vol. 17, No. 9. pp. 819-822.
@article{cee56940fdad4d908498f181603b004d,
title = "Association of fungal colonization and invasive disease in very low birth weight infants",
abstract = "Background. Fungi are common pathogens of nosocomial infections in the very low birth weight (VLBW) infants. The purpose of this study was to investigate the fungal colonization rate in VLBW infants and the association between fungal colonization and systemic fungal diseases. Materials. Between January 1, 1996, and December 31, 1996, 116 infants with birth weight <1500 g admitted to the neonatal intensive care unit of Chang Gung Children's Hospital in the first day of life were included in this prospective study. Methods. Cultures from oropharynx, rectum, skin (groin and axilla), bag urine and endotracheal aspirates were obtained in the first 24 h after birth and weekly thereafter throughout their neonatal intensive care unit stay. Medical records were reviewed weekly. Results. Fungal colonization was detected in 25 infants, among whom 17 infants developed colonization by 2 weeks of life. Candida albicans (61{\%}) and Candida parapsilosis (29{\%}) were the 2 most common organisms. The rectum (76{\%}) was the most frequent site of colonization. Factors significantly associated with colonization were prolonged administration of antibiotic therapy, parenteral nutrition and intralipid emulsion. Three of 116 infants developed fungemia. The association between colonization and subsequent fungemia was demonstrated in 1 infant, representing 4{\%} of colonized infants. Conclusion. Fungal colonization was detected in one-fifth of VLBW infants and represents a risk factor for fungemia. Because disease occurred in the absence of apparent colonization, factors other than colonization may contribute to invasive candidiasis.",
keywords = "Fungal colonization, Invasive candidiasis, Very low birth weight infants",
author = "Huang, {Yhu Chering} and Li, {Chung Chen} and Lin, {Tzou Yien} and Lien, {Rey In} and Chou, {Yi Hong} and Wu, {Jue Lan} and Chuen Hsueh",
year = "1998",
month = "9",
doi = "10.1097/00006454-199809000-00014",
language = "English",
volume = "17",
pages = "819--822",
journal = "Pediatric Infectious Disease Journal",
issn = "0891-3668",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Association of fungal colonization and invasive disease in very low birth weight infants

AU - Huang, Yhu Chering

AU - Li, Chung Chen

AU - Lin, Tzou Yien

AU - Lien, Rey In

AU - Chou, Yi Hong

AU - Wu, Jue Lan

AU - Hsueh, Chuen

PY - 1998/9

Y1 - 1998/9

N2 - Background. Fungi are common pathogens of nosocomial infections in the very low birth weight (VLBW) infants. The purpose of this study was to investigate the fungal colonization rate in VLBW infants and the association between fungal colonization and systemic fungal diseases. Materials. Between January 1, 1996, and December 31, 1996, 116 infants with birth weight <1500 g admitted to the neonatal intensive care unit of Chang Gung Children's Hospital in the first day of life were included in this prospective study. Methods. Cultures from oropharynx, rectum, skin (groin and axilla), bag urine and endotracheal aspirates were obtained in the first 24 h after birth and weekly thereafter throughout their neonatal intensive care unit stay. Medical records were reviewed weekly. Results. Fungal colonization was detected in 25 infants, among whom 17 infants developed colonization by 2 weeks of life. Candida albicans (61%) and Candida parapsilosis (29%) were the 2 most common organisms. The rectum (76%) was the most frequent site of colonization. Factors significantly associated with colonization were prolonged administration of antibiotic therapy, parenteral nutrition and intralipid emulsion. Three of 116 infants developed fungemia. The association between colonization and subsequent fungemia was demonstrated in 1 infant, representing 4% of colonized infants. Conclusion. Fungal colonization was detected in one-fifth of VLBW infants and represents a risk factor for fungemia. Because disease occurred in the absence of apparent colonization, factors other than colonization may contribute to invasive candidiasis.

AB - Background. Fungi are common pathogens of nosocomial infections in the very low birth weight (VLBW) infants. The purpose of this study was to investigate the fungal colonization rate in VLBW infants and the association between fungal colonization and systemic fungal diseases. Materials. Between January 1, 1996, and December 31, 1996, 116 infants with birth weight <1500 g admitted to the neonatal intensive care unit of Chang Gung Children's Hospital in the first day of life were included in this prospective study. Methods. Cultures from oropharynx, rectum, skin (groin and axilla), bag urine and endotracheal aspirates were obtained in the first 24 h after birth and weekly thereafter throughout their neonatal intensive care unit stay. Medical records were reviewed weekly. Results. Fungal colonization was detected in 25 infants, among whom 17 infants developed colonization by 2 weeks of life. Candida albicans (61%) and Candida parapsilosis (29%) were the 2 most common organisms. The rectum (76%) was the most frequent site of colonization. Factors significantly associated with colonization were prolonged administration of antibiotic therapy, parenteral nutrition and intralipid emulsion. Three of 116 infants developed fungemia. The association between colonization and subsequent fungemia was demonstrated in 1 infant, representing 4% of colonized infants. Conclusion. Fungal colonization was detected in one-fifth of VLBW infants and represents a risk factor for fungemia. Because disease occurred in the absence of apparent colonization, factors other than colonization may contribute to invasive candidiasis.

KW - Fungal colonization

KW - Invasive candidiasis

KW - Very low birth weight infants

UR - http://www.scopus.com/inward/record.url?scp=0031670303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031670303&partnerID=8YFLogxK

U2 - 10.1097/00006454-199809000-00014

DO - 10.1097/00006454-199809000-00014

M3 - Article

C2 - 9779769

AN - SCOPUS:0031670303

VL - 17

SP - 819

EP - 822

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 9

ER -