Association of environmental arsenic exposure, genetic polymorphisms of susceptible genes, and skin cancers in Taiwan

Ling I. Hsu, Meei Maan Wu, Yuan Hung Wang, Cheng Yeh Lee, Tse Yen Yang, Bo Yu Hsiao, Chien Jen Chen

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18 Citations (Scopus)

Abstract

Deficiency in the capability of xenobiotic detoxification and arsenic methylation may be correlated with individual susceptibility to arsenic-related skin cancers. We hypothesized that glutathione S-transferase (GST M1, T1, and P1), reactive oxygen species (ROS) related metabolic genes (NQO1, EPHX1, and HO-1), and DNA repair genes (XRCC1, XPD, hOGG1, and ATM) together may play a role in arsenic-induced skin carcinogenesis. We conducted a case-control study consisting of 70 pathologically confirmed skin cancer patients and 210 age and gender matched participants with genotyping of 12 selected polymorphisms. The skin cancer risks were estimated by odds ratio (OR) and 95% confidence interval (CI) using logistic regression. EPHX1 Tyr113His, XPD C156A, and GSTT1 null genotypes were associated with skin cancer risk (OR = 2.99, 95% CI = 1.01-8.83; OR = 2.04, 95% CI = 0.99-4.27; OR = 1.74, 95% CI = 1.00-3.02, resp.). However, none of these polymorphisms showed significant association after considering arsenic exposure status. Individuals carrying three risk polymorphisms of EPHX1 Tyr113His, XPD C156A, and GSTs presented a 400% increased skin cancer risk when compared to those with less than or equal to one polymorphism. In conclusion, GSTs, EPHX1, and XPD are potential genetic factors for arsenic-induced skin cancers. The roles of these genes for arsenic-induced skin carcinogenesis need to be further evaluated.

Original languageEnglish
Article number892579
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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Environmental Exposure
Arsenic
Skin Neoplasms
Genetic Polymorphisms
Polymorphism
Taiwan
Skin
Genes
Odds Ratio
Confidence Intervals
Carcinogenesis
Xenobiotics
DNA Repair
Detoxification
Methylation
Case-Control Studies
Reactive Oxygen Species
Automatic teller machines
Glutathione Transferase
Logistic Models

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Association of environmental arsenic exposure, genetic polymorphisms of susceptible genes, and skin cancers in Taiwan. / Hsu, Ling I.; Wu, Meei Maan; Wang, Yuan Hung; Lee, Cheng Yeh; Yang, Tse Yen; Hsiao, Bo Yu; Chen, Chien Jen.

In: BioMed Research International, Vol. 2015, 892579, 2015.

Research output: Contribution to journalArticle

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