Association of endometrial blood flow as determined by a modified colour Doppler technique with subsequent outcome of in-vitro fertilization

Jehn Hsiahn Yang, Ming Yih Wu, Chin Der Chen, Mau Chaio Jiang, Hong Nerng Ho, Yu Shih Yang

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An endometrial thickness of 10 mm or more has been reported to be favourable for embryo implantation. Nevertheless, many women participating in in-vitro fertilization (IVF) programmes have adequate endometrial thickness but do not achieve satisfactory implantation. With the aid of power Doppler sonography, we examined the association between intra-endometrial vascularity and reproductive outcome. For this study, we enrolled only women with endometrial thickness ≥ 10 mm and excluded those with apparent endometrial pathologies. Of 95 women undergoing IVF cycles, there resulted 37 intrauterine pregnancies. The women were of similar age, body mass index, peak oestradiol concentration and endometrial thickness, and a similar number of embryos were transferred. Those women with an intra-endometrial power Doppler area (EPDA) < 5 mm2 achieved a significantly lower pregnancy rate (23.5 versus 47.5%, P = 0.021) and implantation rate (8.1 versus 20.2%, P = 0.003) than those with an EPDA ≥ 5 mm2. We conclude that, in addition to endometrial thickness, EPDA may serve as a factor indicative of endometrial receptivity. Women with adequate endometrial thickness but a small EPDA tended to have an unfavourable reproductive outcome.

Original languageEnglish
Pages (from-to)1606-1610
Number of pages5
JournalHuman Reproduction
Issue number6
Publication statusPublished - Jan 1 1999
Externally publishedYes



  • Implantation
  • In-vitro fertilization
  • Intra-endometrial power Doppler area (EPDA)
  • Power Doppler

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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