Association of complete blood cell counts with metabolic syndrome in an elderly population

Peng Fei Li, Jin Shuen Chen, Jin Biou Chang, Hsiao Wen Chang, Chung Ze Wu, Tsung Ju Chuang, Chia Luen Huang, Dee Pei, Chang Hsun Hsieh, Yen Lin Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Metabolic syndrome's (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in many different age groups. However, little is known about its role among the elderly. Methods: We enrolled 18,907 subjects over the age of 65 years who underwent regular health examinations. They were divided into three groups according to age: young old (YO: ≥ 65 and <74 years old), old old (OO: ≥ 75 and <84 years old), and oldest old (ODO: ≥ 85 years old). The MetS components were determined, and correlations between MetS and hematogram components were evaluated using Pearson and multivariate linear regression analyses. The hematogram components were the independent variables evaluated separately against the dependent variable (MetS components). Results: While SBP and HDL-C increased, most other MetS and hematogram parameters decreased in men with age. Fewer significant differences were noted among the women. In the YO and OO groups for both genders, the subjects with MetS had higher WBC and Hb. None of the hematogram components were different for subjects with or without MetS in the ODO group. Multiple regression results show that most of the relationships between hematogram and MetS components disappeared in the ODO groups. The WBC levels were mainly correlated with WC and TG. At the same time, Hb was associated with BP, FPG, and LDL-C. Compared to WBC and Hb, PLT was least related to MetS, except in the cases of LDL-C and TG. Among the MetS components, BMI, LDL-C, and TG were consistently related to all the hematogram components in YO and OO men. However, only TG had the same consistency among YO and OO women. Conclusions: This study's three major findings are as follows: WBC and Hb are associated with MetS, even among the YO and OO groups, regardless of gender; among the three hematogram components, Hb had the strongest and PLT had the weakest correlation with MetS; and TG is not the only component with relatively higher r values, and it is related to all hematogram components.

Original languageEnglish
JournalBMC Geriatrics
DOIs
Publication statusAccepted/In press - Jan 13 2016

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Blood Cell Count
Population
Linear Models
Cohort Studies
Cardiovascular Diseases
Age Groups

Keywords

  • Elderly population
  • Hematogram parameters
  • Metabolic syndrome components

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Li, P. F., Chen, J. S., Chang, J. B., Chang, H. W., Wu, C. Z., Chuang, T. J., ... Chen, Y. L. (Accepted/In press). Association of complete blood cell counts with metabolic syndrome in an elderly population. BMC Geriatrics. https://doi.org/10.1186/s12877-016-0182-9

Association of complete blood cell counts with metabolic syndrome in an elderly population. / Li, Peng Fei; Chen, Jin Shuen; Chang, Jin Biou; Chang, Hsiao Wen; Wu, Chung Ze; Chuang, Tsung Ju; Huang, Chia Luen; Pei, Dee; Hsieh, Chang Hsun; Chen, Yen Lin.

In: BMC Geriatrics, 13.01.2016.

Research output: Contribution to journalArticle

Li, PF, Chen, JS, Chang, JB, Chang, HW, Wu, CZ, Chuang, TJ, Huang, CL, Pei, D, Hsieh, CH & Chen, YL 2016, 'Association of complete blood cell counts with metabolic syndrome in an elderly population', BMC Geriatrics. https://doi.org/10.1186/s12877-016-0182-9
Li, Peng Fei ; Chen, Jin Shuen ; Chang, Jin Biou ; Chang, Hsiao Wen ; Wu, Chung Ze ; Chuang, Tsung Ju ; Huang, Chia Luen ; Pei, Dee ; Hsieh, Chang Hsun ; Chen, Yen Lin. / Association of complete blood cell counts with metabolic syndrome in an elderly population. In: BMC Geriatrics. 2016.
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abstract = "Background: Metabolic syndrome's (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in many different age groups. However, little is known about its role among the elderly. Methods: We enrolled 18,907 subjects over the age of 65 years who underwent regular health examinations. They were divided into three groups according to age: young old (YO: ≥ 65 and <74 years old), old old (OO: ≥ 75 and <84 years old), and oldest old (ODO: ≥ 85 years old). The MetS components were determined, and correlations between MetS and hematogram components were evaluated using Pearson and multivariate linear regression analyses. The hematogram components were the independent variables evaluated separately against the dependent variable (MetS components). Results: While SBP and HDL-C increased, most other MetS and hematogram parameters decreased in men with age. Fewer significant differences were noted among the women. In the YO and OO groups for both genders, the subjects with MetS had higher WBC and Hb. None of the hematogram components were different for subjects with or without MetS in the ODO group. Multiple regression results show that most of the relationships between hematogram and MetS components disappeared in the ODO groups. The WBC levels were mainly correlated with WC and TG. At the same time, Hb was associated with BP, FPG, and LDL-C. Compared to WBC and Hb, PLT was least related to MetS, except in the cases of LDL-C and TG. Among the MetS components, BMI, LDL-C, and TG were consistently related to all the hematogram components in YO and OO men. However, only TG had the same consistency among YO and OO women. Conclusions: This study's three major findings are as follows: WBC and Hb are associated with MetS, even among the YO and OO groups, regardless of gender; among the three hematogram components, Hb had the strongest and PLT had the weakest correlation with MetS; and TG is not the only component with relatively higher r values, and it is related to all hematogram components.",
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AU - Chen, Jin Shuen

AU - Chang, Jin Biou

AU - Chang, Hsiao Wen

AU - Wu, Chung Ze

AU - Chuang, Tsung Ju

AU - Huang, Chia Luen

AU - Pei, Dee

AU - Hsieh, Chang Hsun

AU - Chen, Yen Lin

PY - 2016/1/13

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N2 - Background: Metabolic syndrome's (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in many different age groups. However, little is known about its role among the elderly. Methods: We enrolled 18,907 subjects over the age of 65 years who underwent regular health examinations. They were divided into three groups according to age: young old (YO: ≥ 65 and <74 years old), old old (OO: ≥ 75 and <84 years old), and oldest old (ODO: ≥ 85 years old). The MetS components were determined, and correlations between MetS and hematogram components were evaluated using Pearson and multivariate linear regression analyses. The hematogram components were the independent variables evaluated separately against the dependent variable (MetS components). Results: While SBP and HDL-C increased, most other MetS and hematogram parameters decreased in men with age. Fewer significant differences were noted among the women. In the YO and OO groups for both genders, the subjects with MetS had higher WBC and Hb. None of the hematogram components were different for subjects with or without MetS in the ODO group. Multiple regression results show that most of the relationships between hematogram and MetS components disappeared in the ODO groups. The WBC levels were mainly correlated with WC and TG. At the same time, Hb was associated with BP, FPG, and LDL-C. Compared to WBC and Hb, PLT was least related to MetS, except in the cases of LDL-C and TG. Among the MetS components, BMI, LDL-C, and TG were consistently related to all the hematogram components in YO and OO men. However, only TG had the same consistency among YO and OO women. Conclusions: This study's three major findings are as follows: WBC and Hb are associated with MetS, even among the YO and OO groups, regardless of gender; among the three hematogram components, Hb had the strongest and PLT had the weakest correlation with MetS; and TG is not the only component with relatively higher r values, and it is related to all hematogram components.

AB - Background: Metabolic syndrome's (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in many different age groups. However, little is known about its role among the elderly. Methods: We enrolled 18,907 subjects over the age of 65 years who underwent regular health examinations. They were divided into three groups according to age: young old (YO: ≥ 65 and <74 years old), old old (OO: ≥ 75 and <84 years old), and oldest old (ODO: ≥ 85 years old). The MetS components were determined, and correlations between MetS and hematogram components were evaluated using Pearson and multivariate linear regression analyses. The hematogram components were the independent variables evaluated separately against the dependent variable (MetS components). Results: While SBP and HDL-C increased, most other MetS and hematogram parameters decreased in men with age. Fewer significant differences were noted among the women. In the YO and OO groups for both genders, the subjects with MetS had higher WBC and Hb. None of the hematogram components were different for subjects with or without MetS in the ODO group. Multiple regression results show that most of the relationships between hematogram and MetS components disappeared in the ODO groups. The WBC levels were mainly correlated with WC and TG. At the same time, Hb was associated with BP, FPG, and LDL-C. Compared to WBC and Hb, PLT was least related to MetS, except in the cases of LDL-C and TG. Among the MetS components, BMI, LDL-C, and TG were consistently related to all the hematogram components in YO and OO men. However, only TG had the same consistency among YO and OO women. Conclusions: This study's three major findings are as follows: WBC and Hb are associated with MetS, even among the YO and OO groups, regardless of gender; among the three hematogram components, Hb had the strongest and PLT had the weakest correlation with MetS; and TG is not the only component with relatively higher r values, and it is related to all hematogram components.

KW - Elderly population

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