Association of body-mass index to circumference of body and limbs, inspiratory capacity, and inflammatory biomarker in emphysematous patients

Fu Tsai Chung, Wen Ching Joa, Li Fei Chen, Hao Chen Chen, Te Fang Sheng, Han Pin Kuo, Chun Hua Wang

Research output: Contribution to journalArticle

Abstract

Although emphysema primarily affects the lungs, it also has systemic manifestations. Low body mass index (BMI) is a poor prognostic indicator in patients with emphysema. Low BMI, reduced quadriceps muscle mass and elevated inflammatory biomarker may present in emphysema. This study aims to investigate whether BMI is related to airflow limitation, exercise capacity and inflammatory biomarker. Twenty-eight patients with clinically stable emphysema were evaluated for BMI, circumference of chest, abdomen, quadriceps muscle and upper arm, and right upper arm muscle power, airway obstruction, inspiratory capacity (IC), distance of 6-min walking distance (6MWD), oxygen saturation, and serum inflammatory biomarkers [C-reactive protein (CRP), TNF-a and IL-6]. BMI was significantly associated with circumference of chest (r = 0.716, p <0.01), abdomen(r = 0.783, p <0.01), quadriceps muscle (r = 0.565, p <0.01) and upper arm (r = 0.712, p <0.01), IC (r = 0.451, p <0.05), muscle power of right upper arm (r = 0.490, p <0.01) and oxygen saturation (r = 0.380, p <0.05). However, the levels of CRP (1467 ± 202 ug/ml) and IL-6 (8.5 ± 4.2 pg/ml) in emphysematous patients (n = 10) with lower BMI (<21 kg/m2) were significantly higher than those (CRP (911 ± 130 ug/ml, p <0.05) and IL-6 (2.1 ± 0.5 pg/ml, p <0.05)) of patients (n = 18) with higher BMI (>21 kg/m2). BMI associated circumference of limbs, inspiratory capacity, and inflammatory biomarker in emphysematous patients.

Original languageEnglish
Pages (from-to)277-284
Number of pages8
JournalJournal of Internal Medicine of Taiwan
Volume26
Issue number5
Publication statusPublished - Oct 1 2015
Externally publishedYes

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Inspiratory Capacity
Body Mass Index
Extremities
Biomarkers
Emphysema
Quadriceps Muscle
Arm
Thorax
Airway Obstruction
Abdomen
C-Reactive Protein
Walking
Interleukin-6
Exercise
Oxygen
Muscles
Lung
Serum

Keywords

  • Body mass index (BMI)
  • Circumference of body and limbs
  • Emphysema
  • Inspiratory capacity
  • Systemic inflammation

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Association of body-mass index to circumference of body and limbs, inspiratory capacity, and inflammatory biomarker in emphysematous patients. / Chung, Fu Tsai; Joa, Wen Ching; Chen, Li Fei; Chen, Hao Chen; Sheng, Te Fang; Kuo, Han Pin; Wang, Chun Hua.

In: Journal of Internal Medicine of Taiwan, Vol. 26, No. 5, 01.10.2015, p. 277-284.

Research output: Contribution to journalArticle

Chung, Fu Tsai ; Joa, Wen Ching ; Chen, Li Fei ; Chen, Hao Chen ; Sheng, Te Fang ; Kuo, Han Pin ; Wang, Chun Hua. / Association of body-mass index to circumference of body and limbs, inspiratory capacity, and inflammatory biomarker in emphysematous patients. In: Journal of Internal Medicine of Taiwan. 2015 ; Vol. 26, No. 5. pp. 277-284.
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AU - Chung, Fu Tsai

AU - Joa, Wen Ching

AU - Chen, Li Fei

AU - Chen, Hao Chen

AU - Sheng, Te Fang

AU - Kuo, Han Pin

AU - Wang, Chun Hua

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AB - Although emphysema primarily affects the lungs, it also has systemic manifestations. Low body mass index (BMI) is a poor prognostic indicator in patients with emphysema. Low BMI, reduced quadriceps muscle mass and elevated inflammatory biomarker may present in emphysema. This study aims to investigate whether BMI is related to airflow limitation, exercise capacity and inflammatory biomarker. Twenty-eight patients with clinically stable emphysema were evaluated for BMI, circumference of chest, abdomen, quadriceps muscle and upper arm, and right upper arm muscle power, airway obstruction, inspiratory capacity (IC), distance of 6-min walking distance (6MWD), oxygen saturation, and serum inflammatory biomarkers [C-reactive protein (CRP), TNF-a and IL-6]. BMI was significantly associated with circumference of chest (r = 0.716, p <0.01), abdomen(r = 0.783, p <0.01), quadriceps muscle (r = 0.565, p <0.01) and upper arm (r = 0.712, p <0.01), IC (r = 0.451, p <0.05), muscle power of right upper arm (r = 0.490, p <0.01) and oxygen saturation (r = 0.380, p <0.05). However, the levels of CRP (1467 ± 202 ug/ml) and IL-6 (8.5 ± 4.2 pg/ml) in emphysematous patients (n = 10) with lower BMI (<21 kg/m2) were significantly higher than those (CRP (911 ± 130 ug/ml, p <0.05) and IL-6 (2.1 ± 0.5 pg/ml, p <0.05)) of patients (n = 18) with higher BMI (>21 kg/m2). BMI associated circumference of limbs, inspiratory capacity, and inflammatory biomarker in emphysematous patients.

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