Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalJournal of the Neurological Sciences
Volume157
Issue number2
DOIs
Publication statusPublished - May 7 1998
Externally publishedYes

Fingerprint

Presenilin-1
Apolipoproteins E
Taiwan
Gene Frequency
Alzheimer Disease
Genotype
Genes
Control Groups

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Chinese
  • Dementia
  • Genetics
  • Presenilin- 1

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese. / Hu, Chaur Jong; Sung, Shing Ming; Liu, Hsing Cheng; Chang, Jan Gowth.

In: Journal of the Neurological Sciences, Vol. 157, No. 2, 07.05.1998, p. 158-161.

Research output: Contribution to journalArticle

@article{cc679b3cabb54c6a88521d58e397ccb7,
title = "Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese",
abstract = "We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P",
keywords = "Alzheimer's disease, Apolipoprotein E, Chinese, Dementia, Genetics, Presenilin- 1",
author = "Hu, {Chaur Jong} and Sung, {Shing Ming} and Liu, {Hsing Cheng} and Chang, {Jan Gowth}",
year = "1998",
month = "5",
day = "7",
doi = "10.1016/S0022-510X(98)00052-5",
language = "English",
volume = "157",
pages = "158--161",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

AU - Hu, Chaur Jong

AU - Sung, Shing Ming

AU - Liu, Hsing Cheng

AU - Chang, Jan Gowth

PY - 1998/5/7

Y1 - 1998/5/7

N2 - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

AB - We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

KW - Alzheimer's disease

KW - Apolipoprotein E

KW - Chinese

KW - Dementia

KW - Genetics

KW - Presenilin- 1

UR - http://www.scopus.com/inward/record.url?scp=0032493111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032493111&partnerID=8YFLogxK

U2 - 10.1016/S0022-510X(98)00052-5

DO - 10.1016/S0022-510X(98)00052-5

M3 - Article

VL - 157

SP - 158

EP - 161

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 2

ER -