Association of apolipoprotein E genotype and intronic polymorphism of the presenilin-1 gene with Alzheimer's disease in elderly Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We studied the apoliprotein E (apo-E) allele frequencies and intronic polymorphism of the presenilin-1 (PS-1) gene in 55 patients with late-onset Alzheimer's disease (AD) and 93 age- and sex-matched controls. The apoE ε4 allele frequency was significantly higher in the AD group than in the control group (0.255 versus 0.070, P

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalJournal of the Neurological Sciences
Volume157
Issue number2
DOIs
Publication statusPublished - May 7 1998
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Chinese
  • Dementia
  • Genetics
  • Presenilin- 1

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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