Association of Angiotensin Receptor Blockers with Incident Parkinson Disease in Patients with Hypertension: A Retrospective Cohort Study

Hsiu Chen Lin, Yuan Fu Tseng, Ai Ling Shen, Jane Chen Jui Chao, Chien Yeh Hsu, Hsiu Li Lin

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Angiotensin receptor blockers (ARBs), which are commonly used antihypertensives, have been proposed to lower the risk of Parkinson disease by reducing oxidative stress based on animal and in vitro studies. Thus, this study aimed to test this association in patients with newly diagnosed hypertension. Methods: This retrospective cohort study enrolled 107,207 patients with newly diagnosed hypertension between 2001 and 2013. The hazard ratios for Parkinson disease were calculated for ARB treatment compared with those who never used ARBs and among the 5 subgroups receiving different cumulative ARB dosages. Results: We identified 527 (1.1%) Parkinson disease cases among patients with ARB treatment in a median observation period of 8.4 years compared to the 1,255 (2.2%) Parkinson disease cases among those without ARB treatment in a median observation period of 6.8 years. Overall, risk for developing Parkinson disease was statistically lower in the ARB-treated group with a hazard ratio of 0.56 (95% confidence interval: 0.51-0.63) than those without ARB. Conclusions: ARB treatment was associated with a statistically important reduction of Parkinson disease risk in patients with newly diagnosed hypertension. Therefore, ARB may constitute an effective neuroprotective strategy to lower Parkinson disease risk in such patients.

Original languageEnglish
Pages (from-to)1001-1007
Number of pages7
JournalAmerican Journal of Medicine
Volume135
Issue number8
DOIs
Publication statusPublished - Aug 2022

Keywords

  • Angiotensin receptor blocker
  • Hypertension
  • National Health Insurance Research Dataset
  • Parkinson disease
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Medicine(all)

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