Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia

Ming Shun Chung, Albert C. Yang, Yu Chung Lin, Chieh Nan Lin, Fang Rong Chang, Shu hua Shen, Wen Chen Ouyang, El Wui Loh, Hsien Jane Chiu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.

Original languageEnglish
Pages (from-to)710-715
Number of pages6
JournalPsychiatry Research
Volume210
Issue number3
DOIs
Publication statusPublished - Dec 30 2013
Externally publishedYes

Fingerprint

Metabolome
Psychopathology
Schizophrenia
Heart Rate
Psychotic Disorders
Demography
LDL Lipoproteins
Physical Examination
Analysis of Variance
Electrocardiography
Triglycerides
Body Mass Index
Regression Analysis
Blood Pressure
Morbidity
Control Groups
Health

Keywords

  • Autonomic dysregulation
  • Heart rate variability
  • Metabolic syndrome
  • Psychopathology
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Chung, M. S., Yang, A. C., Lin, Y. C., Lin, C. N., Chang, F. R., Shen, S. H., ... Chiu, H. J. (2013). Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia. Psychiatry Research, 210(3), 710-715. https://doi.org/10.1016/j.psychres.2013.07.034

Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia. / Chung, Ming Shun; Yang, Albert C.; Lin, Yu Chung; Lin, Chieh Nan; Chang, Fang Rong; Shen, Shu hua; Ouyang, Wen Chen; Loh, El Wui; Chiu, Hsien Jane.

In: Psychiatry Research, Vol. 210, No. 3, 30.12.2013, p. 710-715.

Research output: Contribution to journalArticle

Chung, MS, Yang, AC, Lin, YC, Lin, CN, Chang, FR, Shen, SH, Ouyang, WC, Loh, EW & Chiu, HJ 2013, 'Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia', Psychiatry Research, vol. 210, no. 3, pp. 710-715. https://doi.org/10.1016/j.psychres.2013.07.034
Chung, Ming Shun ; Yang, Albert C. ; Lin, Yu Chung ; Lin, Chieh Nan ; Chang, Fang Rong ; Shen, Shu hua ; Ouyang, Wen Chen ; Loh, El Wui ; Chiu, Hsien Jane. / Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia. In: Psychiatry Research. 2013 ; Vol. 210, No. 3. pp. 710-715.
@article{59496b71369a461f93c0a2329dbadad3,
title = "Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia",
abstract = "Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.",
keywords = "Autonomic dysregulation, Heart rate variability, Metabolic syndrome, Psychopathology, Schizophrenia",
author = "Chung, {Ming Shun} and Yang, {Albert C.} and Lin, {Yu Chung} and Lin, {Chieh Nan} and Chang, {Fang Rong} and Shen, {Shu hua} and Ouyang, {Wen Chen} and Loh, {El Wui} and Chiu, {Hsien Jane}",
year = "2013",
month = "12",
day = "30",
doi = "10.1016/j.psychres.2013.07.034",
language = "English",
volume = "210",
pages = "710--715",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Association of altered cardiac autonomic function with psychopathology and metabolic profiles in schizophrenia

AU - Chung, Ming Shun

AU - Yang, Albert C.

AU - Lin, Yu Chung

AU - Lin, Chieh Nan

AU - Chang, Fang Rong

AU - Shen, Shu hua

AU - Ouyang, Wen Chen

AU - Loh, El Wui

AU - Chiu, Hsien Jane

PY - 2013/12/30

Y1 - 2013/12/30

N2 - Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.

AB - Schizophrenia has been associated with autonomic dysregulation and increased cardiovascular co-morbidity. We hypothesised that autonomic dysregulation in patients with schizophrenia is associated with psychopathology and metabolic profiles. In this study, we aimed to evaluate psychopathology, comprehensive metabolic profiles and cardiac autonomic function using heart-rate variability (HRV) analysis in patients with schizophrenia. A total of 94 patients with schizophrenia and 51 healthy controls were recruited. Each patient underwent a physical examination, laboratory tests and rating scale evaluation, and all subjects underwent a 1-h electrocardiogram monitoring. Analysis of variance was used to compare demographic and HRV variables between control and patient groups. We applied multiple regression analysis with backward selection to examine the association between HRV indices and demographic, metabolic and psychopathology profiles. A decreased HRV was found in patient groups, compared to controls. Reduced vagal-related and complexity domain of HRV indices in patient groups were correlated with increased body mass indices, diastolic pressure, triglycerides, high- and low-density lipoprotein and severity of psychosis mainly in the negative symptom domain. This study provides evidence that altered autonomic function is associated with both psychopathology and metabolic profiles in patients with schizophrenia. These findings may warrant future research in using HRV as objective markers to monitor cardiovascular health and the severity of psychosis in patients with schizophrenia.

KW - Autonomic dysregulation

KW - Heart rate variability

KW - Metabolic syndrome

KW - Psychopathology

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84888294811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888294811&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2013.07.034

DO - 10.1016/j.psychres.2013.07.034

M3 - Article

VL - 210

SP - 710

EP - 715

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 3

ER -