Association of ABO incompatibility with red blood cell indices of cord blood unit

Shu Huey Chen, Marie Lin, Kuo Liang Yang, Teng Yi Lin, His Hsiu Tsai, Shang Hsien Yang, Yu Hsun Chang, Yi Feng Wu, Tso Fu Wang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Maternal-fetal ABO incompatibility is one of the causes of neonatal hyperbilirubinemia. We postulate that hemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) values for cord blood units (CBUs) are lower and erythroblast values higher for maternal-fetal ABO incompatible dyads than for compatible dyads. Objective: We investigated the relationship between Hb, Hct, RBC, and erythroblast CBU values and maternal-fetal ABO blood type compatibility. Methods: Mothers having blood group O who gave birth to infants with blood group A, B, or AB were classified as Group I. According to baby's blood group, the members of Group I were further divided into AO (baby group A, mother group O), BO (baby group B, mother group O), and ABO (baby group AB, mother group O) subgroups. Mothers having blood group A who gave birth to infants with blood group B or AB and mothers having blood group B who gave birth to infants with blood group A or AB were classified as Group II. All other maternal-fetal blood type pairs were considered ABO compatible and were classified as Group III. We compared mean Hb, Hct, RBC, and erythroblast values for the infants' CBUs among these three groups including the subgroups of Group I. Results: Group I had lower mean Hb, Hct, and RBC values than Group II and Group III (both p <0.001). Although the mean Hb, Hct, and RBC values for Group II were lower than for Group III, the difference was not statistically significant. Mean Hb and RBC for the AO group were higher and nucleated RBC (nRBC) ratios were lower than for the BO group; however, these differences were also not statistically significant. Interestingly, the mean Hct value of the BO group was significantly lower than that of the AO group (p = 0.04). Conclusion: Group A or B neonates with a group O mother have lower mean Hb, Hct, and RBC values for CBUs than other neonates. The role of RBC indices in predicting neonatal hemolytic hyperbilirubinemia remains unclear and further studies are needed to identify the possible clinical association.

Original languageEnglish
Pages (from-to)138-143
Number of pages6
JournalPediatrics and Neonatology
Volume53
Issue number2
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Fingerprint

Erythrocyte Indices
Fetal Blood
Erythrocytes
Mothers
Blood Group Antigens
Hematocrit
Hemoglobins
Erythroblasts
Neonatal Hyperbilirubinemia
Parturition
Newborn Infant

Keywords

  • abo incompatibility
  • cord blood unit
  • hematocrit
  • hemoglobin
  • red blood cell

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Association of ABO incompatibility with red blood cell indices of cord blood unit. / Chen, Shu Huey; Lin, Marie; Yang, Kuo Liang; Lin, Teng Yi; Tsai, His Hsiu; Yang, Shang Hsien; Chang, Yu Hsun; Wu, Yi Feng; Wang, Tso Fu.

In: Pediatrics and Neonatology, Vol. 53, No. 2, 04.2012, p. 138-143.

Research output: Contribution to journalArticle

Chen, SH, Lin, M, Yang, KL, Lin, TY, Tsai, HH, Yang, SH, Chang, YH, Wu, YF & Wang, TF 2012, 'Association of ABO incompatibility with red blood cell indices of cord blood unit', Pediatrics and Neonatology, vol. 53, no. 2, pp. 138-143. https://doi.org/10.1016/j.pedneo.2012.01.012
Chen, Shu Huey ; Lin, Marie ; Yang, Kuo Liang ; Lin, Teng Yi ; Tsai, His Hsiu ; Yang, Shang Hsien ; Chang, Yu Hsun ; Wu, Yi Feng ; Wang, Tso Fu. / Association of ABO incompatibility with red blood cell indices of cord blood unit. In: Pediatrics and Neonatology. 2012 ; Vol. 53, No. 2. pp. 138-143.
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abstract = "Background: Maternal-fetal ABO incompatibility is one of the causes of neonatal hyperbilirubinemia. We postulate that hemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) values for cord blood units (CBUs) are lower and erythroblast values higher for maternal-fetal ABO incompatible dyads than for compatible dyads. Objective: We investigated the relationship between Hb, Hct, RBC, and erythroblast CBU values and maternal-fetal ABO blood type compatibility. Methods: Mothers having blood group O who gave birth to infants with blood group A, B, or AB were classified as Group I. According to baby's blood group, the members of Group I were further divided into AO (baby group A, mother group O), BO (baby group B, mother group O), and ABO (baby group AB, mother group O) subgroups. Mothers having blood group A who gave birth to infants with blood group B or AB and mothers having blood group B who gave birth to infants with blood group A or AB were classified as Group II. All other maternal-fetal blood type pairs were considered ABO compatible and were classified as Group III. We compared mean Hb, Hct, RBC, and erythroblast values for the infants' CBUs among these three groups including the subgroups of Group I. Results: Group I had lower mean Hb, Hct, and RBC values than Group II and Group III (both p <0.001). Although the mean Hb, Hct, and RBC values for Group II were lower than for Group III, the difference was not statistically significant. Mean Hb and RBC for the AO group were higher and nucleated RBC (nRBC) ratios were lower than for the BO group; however, these differences were also not statistically significant. Interestingly, the mean Hct value of the BO group was significantly lower than that of the AO group (p = 0.04). Conclusion: Group A or B neonates with a group O mother have lower mean Hb, Hct, and RBC values for CBUs than other neonates. The role of RBC indices in predicting neonatal hemolytic hyperbilirubinemia remains unclear and further studies are needed to identify the possible clinical association.",
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AU - Lin, Marie

AU - Yang, Kuo Liang

AU - Lin, Teng Yi

AU - Tsai, His Hsiu

AU - Yang, Shang Hsien

AU - Chang, Yu Hsun

AU - Wu, Yi Feng

AU - Wang, Tso Fu

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N2 - Background: Maternal-fetal ABO incompatibility is one of the causes of neonatal hyperbilirubinemia. We postulate that hemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) values for cord blood units (CBUs) are lower and erythroblast values higher for maternal-fetal ABO incompatible dyads than for compatible dyads. Objective: We investigated the relationship between Hb, Hct, RBC, and erythroblast CBU values and maternal-fetal ABO blood type compatibility. Methods: Mothers having blood group O who gave birth to infants with blood group A, B, or AB were classified as Group I. According to baby's blood group, the members of Group I were further divided into AO (baby group A, mother group O), BO (baby group B, mother group O), and ABO (baby group AB, mother group O) subgroups. Mothers having blood group A who gave birth to infants with blood group B or AB and mothers having blood group B who gave birth to infants with blood group A or AB were classified as Group II. All other maternal-fetal blood type pairs were considered ABO compatible and were classified as Group III. We compared mean Hb, Hct, RBC, and erythroblast values for the infants' CBUs among these three groups including the subgroups of Group I. Results: Group I had lower mean Hb, Hct, and RBC values than Group II and Group III (both p <0.001). Although the mean Hb, Hct, and RBC values for Group II were lower than for Group III, the difference was not statistically significant. Mean Hb and RBC for the AO group were higher and nucleated RBC (nRBC) ratios were lower than for the BO group; however, these differences were also not statistically significant. Interestingly, the mean Hct value of the BO group was significantly lower than that of the AO group (p = 0.04). Conclusion: Group A or B neonates with a group O mother have lower mean Hb, Hct, and RBC values for CBUs than other neonates. The role of RBC indices in predicting neonatal hemolytic hyperbilirubinemia remains unclear and further studies are needed to identify the possible clinical association.

AB - Background: Maternal-fetal ABO incompatibility is one of the causes of neonatal hyperbilirubinemia. We postulate that hemoglobin (Hb), hematocrit (Hct), and red blood cell (RBC) values for cord blood units (CBUs) are lower and erythroblast values higher for maternal-fetal ABO incompatible dyads than for compatible dyads. Objective: We investigated the relationship between Hb, Hct, RBC, and erythroblast CBU values and maternal-fetal ABO blood type compatibility. Methods: Mothers having blood group O who gave birth to infants with blood group A, B, or AB were classified as Group I. According to baby's blood group, the members of Group I were further divided into AO (baby group A, mother group O), BO (baby group B, mother group O), and ABO (baby group AB, mother group O) subgroups. Mothers having blood group A who gave birth to infants with blood group B or AB and mothers having blood group B who gave birth to infants with blood group A or AB were classified as Group II. All other maternal-fetal blood type pairs were considered ABO compatible and were classified as Group III. We compared mean Hb, Hct, RBC, and erythroblast values for the infants' CBUs among these three groups including the subgroups of Group I. Results: Group I had lower mean Hb, Hct, and RBC values than Group II and Group III (both p <0.001). Although the mean Hb, Hct, and RBC values for Group II were lower than for Group III, the difference was not statistically significant. Mean Hb and RBC for the AO group were higher and nucleated RBC (nRBC) ratios were lower than for the BO group; however, these differences were also not statistically significant. Interestingly, the mean Hct value of the BO group was significantly lower than that of the AO group (p = 0.04). Conclusion: Group A or B neonates with a group O mother have lower mean Hb, Hct, and RBC values for CBUs than other neonates. The role of RBC indices in predicting neonatal hemolytic hyperbilirubinemia remains unclear and further studies are needed to identify the possible clinical association.

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