Association between tumor necrosis factor α-308 G/A polymorphism and bladder cancer risk: A meta-analysis

Cheng Huang Shen, Wei Tang Kao, Min Che Tung, Kuan Chun Hsueh, Chia Chang Wu, Yuan Hung Wang

Research output: Contribution to journalArticle

Abstract

Previous studies have investigated the association between TNF-α -308 G/A polymorphism and bladder cancer risk in various populations. However, these findings remain inconclusive. Therefore, we performed a meta-analysis to explore the relationship between TNF-α -308 G/A polymorphism and bladder cancer risk. A literature search in PubMed was performed to select eligible studies regarding the association between TNF-α -308 G/A polymorphism and bladder cancer risk. The strength of risk under fixed- and random-effects models were estimated using the odds ratios (ORs) with 95% confidence intervals (CIs). We collected 7 case-control studies including 1153 cases and 1587 controls were included in the present meta-analysis. Compared with subjects carrying the G/G genotype of TNF-α -308 G/A polymorphism, those with the A/A and G/A genotypes had non-significant bladder cancer risks under the fixed effects model (OR=1.037) and the random effects model (OR=1.012). In the recessive model, subjects with the A/A genotype had an increased bladder cancer risk (OR=1.875) compared with those carrying the G/A and G/G genotypes of TNF-α -308 G/A polymorphism. The major finding of this meta-analysis suggests that TNF-α -308 G/A polymorphism is correlated with the risk of bladder cancer in Asian population under the recessive model. Further investigate of the joint effects of environmental risk factors and TNF-α -308 G/A polymorphism on bladder cancer risk should be considered.

Original languageEnglish
Pages (from-to)14205-14211
Number of pages7
JournalInternational Journal of Clinical and Experimental Medicine
Volume9
Issue number7
Publication statusPublished - Jul 30 2016

Keywords

  • Bladder cancer
  • Meta-analysis
  • Polymorphism
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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