Abstract

This population-based study in Taiwan aimed to investigate the risk of having a diagnosis of malignant brain tumors within 3 years after a traumatic brain injury (TBI). This study used data from the Traumatic Brain Injury Registry and the National Health Insurance Research Database. The study cohort comprised 5007 patients who had visited ambulatory care centers or had been hospitalized with a diagnosis of TBI between 2001 and 2002. The comparison cohort was 25,035 randomly selected enrollees. Each patient's brain cancer status was individually tracked for a 3-year period following their index date. Stratified Cox proportional hazards regressions were performed for analyses. During the 3 years of follow-up, nine patients in each cohort, both the TBI and the non-TBI cohort, were diagnosed with brain cancer. As compared to those patients without TBI, patients with TBI were more likely to receive a diagnosis of malignant brain tumors within the 3-year period following their index date: the incidence rate of malignant brain tumors was 6.28 (95% CI: 3.06-11.53) per 10,000 person-years in patients with TBI and 1.25 (95% CI: 0.61-2.29) per 10,000 person-years in patients without TBI. After adjusting for sociodemographic characteristics, the hazard of being diagnosed with malignant brain tumors during the 3-year follow-up period was 4.67 (95% CI: 1.84-11.83) times greater for those who sustained a TBI than for patients in the comparison cohort. In addition, we found an association between TBI severity and malignant brain tumor among patients with TBI (p=0.033). Our findings suggest a positive correlation between TBI and the relatively short-term development of malignant neoplasms of the brain.

Original languageEnglish
Pages (from-to)1328-1333
Number of pages6
JournalJournal of Neurotrauma
Volume29
Issue number7
DOIs
Publication statusPublished - May 1 2012

Fingerprint

Brain Neoplasms
Traumatic Brain Injury
National Health Programs
Ambulatory Care
Taiwan
Brain Injuries
Registries
Cohort Studies
Databases

Keywords

  • epidemiology
  • malignant brain tumors
  • TBI

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Association between traumatic brain injury and the subsequent risk of brain cancer. / Chen, Yi Hua; Keller, Joseph J.; Kang, Jiunn Horng; Lin, Herng Ching.

In: Journal of Neurotrauma, Vol. 29, No. 7, 01.05.2012, p. 1328-1333.

Research output: Contribution to journalArticle

@article{177f70a81021401baa200812a0894fd7,
title = "Association between traumatic brain injury and the subsequent risk of brain cancer",
abstract = "This population-based study in Taiwan aimed to investigate the risk of having a diagnosis of malignant brain tumors within 3 years after a traumatic brain injury (TBI). This study used data from the Traumatic Brain Injury Registry and the National Health Insurance Research Database. The study cohort comprised 5007 patients who had visited ambulatory care centers or had been hospitalized with a diagnosis of TBI between 2001 and 2002. The comparison cohort was 25,035 randomly selected enrollees. Each patient's brain cancer status was individually tracked for a 3-year period following their index date. Stratified Cox proportional hazards regressions were performed for analyses. During the 3 years of follow-up, nine patients in each cohort, both the TBI and the non-TBI cohort, were diagnosed with brain cancer. As compared to those patients without TBI, patients with TBI were more likely to receive a diagnosis of malignant brain tumors within the 3-year period following their index date: the incidence rate of malignant brain tumors was 6.28 (95{\%} CI: 3.06-11.53) per 10,000 person-years in patients with TBI and 1.25 (95{\%} CI: 0.61-2.29) per 10,000 person-years in patients without TBI. After adjusting for sociodemographic characteristics, the hazard of being diagnosed with malignant brain tumors during the 3-year follow-up period was 4.67 (95{\%} CI: 1.84-11.83) times greater for those who sustained a TBI than for patients in the comparison cohort. In addition, we found an association between TBI severity and malignant brain tumor among patients with TBI (p=0.033). Our findings suggest a positive correlation between TBI and the relatively short-term development of malignant neoplasms of the brain.",
keywords = "epidemiology, malignant brain tumors, TBI",
author = "Chen, {Yi Hua} and Keller, {Joseph J.} and Kang, {Jiunn Horng} and Lin, {Herng Ching}",
year = "2012",
month = "5",
day = "1",
doi = "10.1089/neu.2011.2235",
language = "English",
volume = "29",
pages = "1328--1333",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Association between traumatic brain injury and the subsequent risk of brain cancer

AU - Chen, Yi Hua

AU - Keller, Joseph J.

AU - Kang, Jiunn Horng

AU - Lin, Herng Ching

PY - 2012/5/1

Y1 - 2012/5/1

N2 - This population-based study in Taiwan aimed to investigate the risk of having a diagnosis of malignant brain tumors within 3 years after a traumatic brain injury (TBI). This study used data from the Traumatic Brain Injury Registry and the National Health Insurance Research Database. The study cohort comprised 5007 patients who had visited ambulatory care centers or had been hospitalized with a diagnosis of TBI between 2001 and 2002. The comparison cohort was 25,035 randomly selected enrollees. Each patient's brain cancer status was individually tracked for a 3-year period following their index date. Stratified Cox proportional hazards regressions were performed for analyses. During the 3 years of follow-up, nine patients in each cohort, both the TBI and the non-TBI cohort, were diagnosed with brain cancer. As compared to those patients without TBI, patients with TBI were more likely to receive a diagnosis of malignant brain tumors within the 3-year period following their index date: the incidence rate of malignant brain tumors was 6.28 (95% CI: 3.06-11.53) per 10,000 person-years in patients with TBI and 1.25 (95% CI: 0.61-2.29) per 10,000 person-years in patients without TBI. After adjusting for sociodemographic characteristics, the hazard of being diagnosed with malignant brain tumors during the 3-year follow-up period was 4.67 (95% CI: 1.84-11.83) times greater for those who sustained a TBI than for patients in the comparison cohort. In addition, we found an association between TBI severity and malignant brain tumor among patients with TBI (p=0.033). Our findings suggest a positive correlation between TBI and the relatively short-term development of malignant neoplasms of the brain.

AB - This population-based study in Taiwan aimed to investigate the risk of having a diagnosis of malignant brain tumors within 3 years after a traumatic brain injury (TBI). This study used data from the Traumatic Brain Injury Registry and the National Health Insurance Research Database. The study cohort comprised 5007 patients who had visited ambulatory care centers or had been hospitalized with a diagnosis of TBI between 2001 and 2002. The comparison cohort was 25,035 randomly selected enrollees. Each patient's brain cancer status was individually tracked for a 3-year period following their index date. Stratified Cox proportional hazards regressions were performed for analyses. During the 3 years of follow-up, nine patients in each cohort, both the TBI and the non-TBI cohort, were diagnosed with brain cancer. As compared to those patients without TBI, patients with TBI were more likely to receive a diagnosis of malignant brain tumors within the 3-year period following their index date: the incidence rate of malignant brain tumors was 6.28 (95% CI: 3.06-11.53) per 10,000 person-years in patients with TBI and 1.25 (95% CI: 0.61-2.29) per 10,000 person-years in patients without TBI. After adjusting for sociodemographic characteristics, the hazard of being diagnosed with malignant brain tumors during the 3-year follow-up period was 4.67 (95% CI: 1.84-11.83) times greater for those who sustained a TBI than for patients in the comparison cohort. In addition, we found an association between TBI severity and malignant brain tumor among patients with TBI (p=0.033). Our findings suggest a positive correlation between TBI and the relatively short-term development of malignant neoplasms of the brain.

KW - epidemiology

KW - malignant brain tumors

KW - TBI

UR - http://www.scopus.com/inward/record.url?scp=84860308056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860308056&partnerID=8YFLogxK

U2 - 10.1089/neu.2011.2235

DO - 10.1089/neu.2011.2235

M3 - Article

VL - 29

SP - 1328

EP - 1333

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 7

ER -