Abstract

Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 % CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 % CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 % CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.

Original languageEnglish
Pages (from-to)7147-7153
Number of pages7
JournalTumor Biology
Volume35
Issue number7
DOIs
Publication statusPublished - 2014

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Urinary Bladder Neoplasms
Meta-Analysis
Odds Ratio
Confidence Intervals
Genotype
Case-Control Studies
Population

Keywords

  • Bladder cancer
  • Meta-analysis
  • Polymorphisms
  • Sulfotransferase 1A1

ASJC Scopus subject areas

  • Cancer Research

Cite this

@article{825e8721635844baafcf4443190d3433,
title = "Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer: A meta-analysis",
abstract = "Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 {\%} confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 {\%} CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 {\%} CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 {\%} CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.",
keywords = "Bladder cancer, Meta-analysis, Polymorphisms, Sulfotransferase 1A1",
author = "Su, {Chih Ming} and Mei-Chieh Chen and I-Chan Lin and Chen, {Hsin An} and Ming-Te Huang and Chih-Hsiung Wu and Shen, {Kun Hung} and Yuan-Hung Wang",
year = "2014",
doi = "10.1007/s13277-014-1954-5",
language = "English",
volume = "35",
pages = "7147--7153",
journal = "Tumor Biology",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "7",

}

TY - JOUR

T1 - Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer

T2 - A meta-analysis

AU - Su, Chih Ming

AU - Chen, Mei-Chieh

AU - Lin, I-Chan

AU - Chen, Hsin An

AU - Huang, Ming-Te

AU - Wu, Chih-Hsiung

AU - Shen, Kun Hung

AU - Wang, Yuan-Hung

PY - 2014

Y1 - 2014

N2 - Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 % CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 % CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 % CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.

AB - Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR=1.218, 95 % CI=1.067-1.392, P=0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR=1.269, 95 % CI=1.069-1.506, P=0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR=1.428, 95 % CI=1.079-1.890, P=0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.

KW - Bladder cancer

KW - Meta-analysis

KW - Polymorphisms

KW - Sulfotransferase 1A1

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U2 - 10.1007/s13277-014-1954-5

DO - 10.1007/s13277-014-1954-5

M3 - Article

C2 - 24763827

AN - SCOPUS:84904875116

VL - 35

SP - 7147

EP - 7153

JO - Tumor Biology

JF - Tumor Biology

SN - 1010-4283

IS - 7

ER -