Association Between Survivin Gene Promoter -31 C/G Polymorphism and Urothelial Carcinoma Risk in Taiwanese Population

Yuan Hung Wang, Hung Yi Chiou, Chang Te Lin, Hsiao Yen Hsieh, Chia Chang Wu, Cheng Da Hsu, Cheng Huang Shen

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objectives: To investigate the association between survivin gene promoter -31 C/G polymorphism and urothelial carcinoma (UC) risk in a Taiwanese population. Methods: A total of 190 patients with pathologically confirmed UC and 210 unrelated controls without cancer were recruited at Chiayi Christian Hospital from August 2002 to May 2007. The -31 C/G polymorphism in the survivin gene promoter was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Results: Compared with study subjects carrying the G/G genotype, significantly increased UC risks were found for individuals carrying the C/G genotype (odds ratio 2.8; 95% confidence interval [CI] 1.7-4.6) and those with the C/C genotype (odds ratio 4.0; 95% CI 2.3-7.2). Those carrying the C/C or C/G genotype had a significantly increased UC risk of 3.2 (95% CI 1.9-5.2) compared with those with the G/G genotype. Among heavy smokers (≥30 pack-years), we found a significantly increased UC risk of 3.8 (95% CI 1.3-11.3) for individuals with the C/C or C/G genotype compared with those with the G/G genotype. Furthermore, patients with UC carrying the C/C genotype had a significantly greater prevalence of muscle-invasive (Stage T2-T4), high-grade (G3), or invasive, high-grade tumor compared with those carrying the G/G genotype. Conclusions: These findings suggest that the -31 C/G polymorphism of the survivin gene promoter is associated with both the clinical tumor stage and the pathologic tumor grade and might be involved in the development of UC.

Original languageEnglish
Pages (from-to)670-674
Number of pages5
JournalUrology
Volume73
Issue number3
DOIs
Publication statusPublished - Mar 2009
Externally publishedYes

Keywords

  • Transitional Cell
  • Carcinoma
  • Microtubule-Associated Proteins

ASJC Scopus subject areas

  • Urology

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