Association Between Statin Use and Bell’s Palsy: A Population-Based Study

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Methods: This case-control study identified 1,977 subjects with Bell’s palsy as cases and 5,931 sex- and age-matched subjects without Bell’s palsy as controls from the Taiwan Longitudinal Health Insurance Database 2000. Conditional logistic regressions was used to estimate the odds ratio (OR) and 95 % confidence interval (CI) for previous use of statins between the cases and controls. The associations of regular and irregular statin users with Bell’s palsy were further analyzed.

Background: Several reports mention that statin (HMG-CoA reductase inhibitor) use seems to be associated with several neurologic disorders and that the lipid-lowering effect of statins may contribute to some neural toxicity.

Objective: This study aimed to evaluate the association between statin use and Bell’s palsy using a population-based health insurance database.

Results: By Chi-square test, there was a significant difference in the prevalence of statin use between cases and controls (23.2 vs. 16.4 %, p 

Conclusions: Our present data suggest a potential association between regular statin use and Bell’s palsy.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalDrug Safety
Volume37
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Bell Palsy
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Population
Health insurance
Health Insurance
Databases
Chi-Square Distribution
Nervous System Diseases
Toxicity
Logistics
Taiwan
Case-Control Studies
Logistic Models
Lipids
Odds Ratio
Confidence Intervals

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Toxicology
  • Medicine(all)

Cite this

Association Between Statin Use and Bell’s Palsy : A Population-Based Study. / Hung, Shih-Han; Wang, Li-Hsuan; Lin, Herng-Ching; Chung, Shiu Dong.

In: Drug Safety, Vol. 37, No. 9, 2014, p. 735-742.

Research output: Contribution to journalArticle

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