Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever

Nguyen Thanh Hung, Nguyen Trong Lan, Huan Yao Lei, Yee Shin Lin, Le Bich Lien, Kao Jean Huang, Chiou Feng Lin, Do Quang Ha, Vu Thi Que Huong, Lam Thi My, Trai Ming Yeh, Jyh Hsiung Huang, Ching Chuan Liu, Scott B. Halstead

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Abstract

The association between sex, nutritional status, and the severity of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), and immune status was investigated in 245 Vietnamese infants with predominantly primary infections with dengue virus. Male and female infants were at equal risk of developing DHF/DSS. However, infants of low height and weight for age were under-represented among DHF/DSS cases compared with 533 healthy baby clinic infant controls. Acute illness phase blood levels of selected cytokines (interferon-γ and tumor necrosis factor-α) and serum levels of antibodies to dengue virus were elevated in the same range in male and female infants with DHF/DSS, as well as in infants with and without malnutrition.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume72
Issue number4
Publication statusPublished - Apr 2005
Externally publishedYes

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Hung, N. T., Lan, N. T., Lei, H. Y., Lin, Y. S., Lien, L. B., Huang, K. J., Lin, C. F., Ha, D. Q., Huong, V. T. Q., My, L. T., Yeh, T. M., Huang, J. H., Liu, C. C., & Halstead, S. B. (2005). Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene, 72(4), 370-374.