Association between sepsis and dementia

Li Ting Kao, Jau Jiuan Sheu, Herng Ching Lin, Ming Chieh Tsai, Shiu Dong Chung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study, we explored the association between sepsis and dementia using a population-based dataset in Taiwan and a case-control design. The relationship between severe systemic infections and dementia is still unclear. Data for this case-control study were taken from the Taiwan Longitudinal Health Insurance Database 2000. This study included 5955 patients with dementia and 5955 sex and age-matched healthy controls. We performed conditional logistic regressions to examine the association of dementia with previously diagnosed sepsis. We found that 168 (1.41%) of the sampled people had been hospitalized for treatment of sepsis before the index date, 122 patients (2.05%) and 46 controls (0.77%; p <0.001). The conditional logistic regression indicated that patients with dementia were more likely to have been previously diagnosed with sepsis than controls after adjusting for monthly income, urbanization level, hyperlipidemia, and diabetes (odds ratio [OR] 2.60; 95% confidence interval [CI] 1.84-3.66). We also found that dementia was associated with prior sepsis regardless of sex (males: adjusted OR 3.17; 95% CI 1.76-5.68; females: adjusted OR 2.27; 95% CI 1.48-3.47). We concluded that patients with dementia had a higher odds of previous sepsis compared to the control group.

Original languageEnglish
Pages (from-to)1430-1433
Number of pages4
JournalJournal of Clinical Neuroscience
Volume22
Issue number9
DOIs
Publication statusPublished - 2015

Fingerprint

Dementia
Sepsis
Odds Ratio
Confidence Intervals
Taiwan
Logistic Models
Urbanization
Health Insurance
Hyperlipidemias
Case-Control Studies
Databases
Control Groups
Infection
Population

Keywords

  • Case-control study
  • Dementia
  • Epidemiology
  • Infection
  • Sepsis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Association between sepsis and dementia. / Kao, Li Ting; Sheu, Jau Jiuan; Lin, Herng Ching; Tsai, Ming Chieh; Chung, Shiu Dong.

In: Journal of Clinical Neuroscience, Vol. 22, No. 9, 2015, p. 1430-1433.

Research output: Contribution to journalArticle

Kao, Li Ting ; Sheu, Jau Jiuan ; Lin, Herng Ching ; Tsai, Ming Chieh ; Chung, Shiu Dong. / Association between sepsis and dementia. In: Journal of Clinical Neuroscience. 2015 ; Vol. 22, No. 9. pp. 1430-1433.
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