Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan

Chih Ching Yeh, Fung Chang Sung, Reiping Tang, Chung Rong Chang-Chieh, Ling Ling Hsieh

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The relationship between diet and colorectal cancer has been previously demonstrated and supported with strong epidemiological evidence. The role of genetic polymorphisms has, however, been less well elaborated upon. We conducted a hospital-based case-control study including 727 cases and 736 healthy controls to evaluate the associations of the polymorphic phase-I and -II biotransformations (CYP1A1, CYP1A2, GSTM1, GSTT1, GSTP1, NAT1 and NAT2) and DNA-repair enzymes (XRCC1, XRCC3 and XPD) with the risk of contracting colorectal cancer. We found that men featuring the CYP1A1*2C G/G genotype, the GSTT1 null genotype and XPD 751 with the Gln allele were associated with an elevated risk of colorectal cancer than were men who did not exhibit such genetic features. Multivariate logistic regression analysis revealed that individuals featuring more than two high-risk genotypes increased the colorectal-cancer risk 3.1-fold (OR = 3.1, 95% CI = 1.8-5.2). For women, subjects featuring the CYP1A1*2C G/G genotype and the XRCC3 Thr/Thr genotype faced a 3.1-fold greater risk (95% CI = 1.3-7.0) of colorectal cancer when compared to those featuring the CYP1A1*2C A allele and the XRCC3 Met allele. Taken together, this study suggests that polymorphisms of genes involved in biotransformation and DNA repair could modulate colorectal-cancer risk in Taiwan.

Original languageEnglish
Pages (from-to)183-193
Number of pages11
JournalJournal of Biomedical Science
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

Fingerprint

Biotransformation
Polymorphism
Taiwan
DNA Repair
Colorectal Neoplasms
Cytochrome P-450 CYP1A1
Repair
Genes
Genotype
DNA
Alleles
DNA Repair Enzymes
Cytochrome P-450 CYP1A2
Genetic Polymorphisms
Nutrition
Regression analysis
Logistics
Case-Control Studies
Logistic Models
Regression Analysis

Keywords

  • Biotransformation
  • Colorectal cancer
  • DNA repair
  • Polymorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. / Yeh, Chih Ching; Sung, Fung Chang; Tang, Reiping; Chang-Chieh, Chung Rong; Hsieh, Ling Ling.

In: Journal of Biomedical Science, Vol. 14, No. 2, 03.2007, p. 183-193.

Research output: Contribution to journalArticle

Yeh, Chih Ching ; Sung, Fung Chang ; Tang, Reiping ; Chang-Chieh, Chung Rong ; Hsieh, Ling Ling. / Association between polymorphisms of biotransformation and DNA-repair genes and risk of colorectal cancer in Taiwan. In: Journal of Biomedical Science. 2007 ; Vol. 14, No. 2. pp. 183-193.
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