Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

Ching-Yu Lai, Ling-Ling Hsieh, Reiping Tang, Regina M Santella, Chung Rong Chang-Chieh, Chih-Ching Yeh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIM: To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.

METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses on the basis of sex, age at diagnosis, and tumor subsite and stage were performed.

RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype (OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage III + IV cancer (OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657G allele carriers had a 41% reduced CRC risk among stage 0-II patients (OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele (OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656G haplotype was also associated with a significant CRC risk in females (OR = 1.36, 95%CI: 1.03-1.78).

CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwanese population.

Original languageEnglish
Pages (from-to)3372-80
Number of pages9
JournalWorld Journal of Gastroenterology
Volume22
Issue number12
DOIs
Publication statusPublished - Mar 28 2016

Fingerprint

Taiwan
Colorectal Neoplasms
Haplotypes
Alleles
Genotype
Genetic Polymorphisms
Neoplasms
Adenocarcinoma
Software
Logistic Models
Polymerase Chain Reaction
DNA
Population

Keywords

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan. / Lai, Ching-Yu; Hsieh, Ling-Ling; Tang, Reiping; Santella, Regina M; Chang-Chieh, Chung Rong; Yeh, Chih-Ching.

In: World Journal of Gastroenterology, Vol. 22, No. 12, 28.03.2016, p. 3372-80.

Research output: Contribution to journalArticle

Lai, Ching-Yu ; Hsieh, Ling-Ling ; Tang, Reiping ; Santella, Regina M ; Chang-Chieh, Chung Rong ; Yeh, Chih-Ching. / Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan. In: World Journal of Gastroenterology. 2016 ; Vol. 22, No. 12. pp. 3372-80.
@article{6980aa4587944b7bb78bbd2838652593,
title = "Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan",
abstract = "AIM: To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95{\%}CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses on the basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype (OR = 1.38, 95{\%}CI: 1.03-1.85, P = 0.030), particularly high in patients with stage III + IV cancer (OR = 1.48, 95{\%}CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657G allele carriers had a 41{\%} reduced CRC risk among stage 0-II patients (OR = 0.59, 95{\%}CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele (OR = 1.41, 95{\%}CI: 1.02-1.96). The APE1 148Glu/-656G haplotype was also associated with a significant CRC risk in females (OR = 1.36, 95{\%}CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwanese population.",
keywords = "Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, APE1, Colorectal cancer, OGG1, Polymorphisms, Taiwan",
author = "Ching-Yu Lai and Ling-Ling Hsieh and Reiping Tang and Santella, {Regina M} and Chang-Chieh, {Chung Rong} and Chih-Ching Yeh",
year = "2016",
month = "3",
day = "28",
doi = "10.3748/wjg.v22.i12.3372",
language = "English",
volume = "22",
pages = "3372--80",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "12",

}

TY - JOUR

T1 - Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

AU - Lai, Ching-Yu

AU - Hsieh, Ling-Ling

AU - Tang, Reiping

AU - Santella, Regina M

AU - Chang-Chieh, Chung Rong

AU - Yeh, Chih-Ching

PY - 2016/3/28

Y1 - 2016/3/28

N2 - AIM: To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses on the basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype (OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage III + IV cancer (OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657G allele carriers had a 41% reduced CRC risk among stage 0-II patients (OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele (OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656G haplotype was also associated with a significant CRC risk in females (OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwanese population.

AB - AIM: To evaluate the effects of OGG1 (Ser326Cys, 11657A/G, and Arg154His) and APE1 (Asp148Glu, and T-656G) polymorphisms on colorectal cancer (CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses on the basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype (OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage III + IV cancer (OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657G allele carriers had a 41% reduced CRC risk among stage 0-II patients (OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele (OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656G haplotype was also associated with a significant CRC risk in females (OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwanese population.

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - APE1

KW - Colorectal cancer

KW - OGG1

KW - Polymorphisms

KW - Taiwan

U2 - 10.3748/wjg.v22.i12.3372

DO - 10.3748/wjg.v22.i12.3372

M3 - Article

VL - 22

SP - 3372

EP - 3380

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 12

ER -