Association between Parkinson's disease and inflammatory bowel disease

A nationwide Taiwanese retrospective cohort study

Jung Chun Lin, Chin Sheng Lin, Chin Wang Hsu, Cheng Li Lin, Chia Hung Kao

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Objectives: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that chronic systemic inflammation increases the risk of Parkinson's disease (PD). This study examined the effects of IBD on the development of PD. Methods: In a nationwide population-based cohort of 23.22 million insured residents of Taiwan aged ≥ 20 years, we compared people diagnosed with IBD during 2000 to 2011 (n 8373) with IBD-free individuals. Patients with PD were identified in the National Health Insurance Research Database. Using univariable and multivariable Cox proportion hazard regression models, we estimated the adjusted hazard ratio (aHR) for PD with a 95% confidence interval (CI) with adjustment for age, sex, and comorbidities. Results: In the cohort, IBD was associated with an increased incidence of PD (crude hazard ratio 1.43, 95% CI 1.15-1.79). The risk was highest among individuals with Crohn's disease (aHR 1.40, 95% CI 1.11-1.77). In the multivariable model, the risk of PD was increased for men (aHR 1.28, 95% CI 1.05-1.56) and higher for patients with hypertension (aHR 1.72, 95% CI 1.33-2.24), coronary artery disease (aHR 1.31, 95% CI 1.04-1.66), or depression (aHR 2.51, 95% CI 1.82-3.46). Conclusions: We suggest that IBD is associated with an increased risk of PD. Patients with IBD should be aware of the potential risk for PD development.

Original languageEnglish
Pages (from-to)1049-1055
Number of pages7
JournalInflammatory Bowel Diseases
Volume22
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Inflammatory Bowel Diseases
Parkinson Disease
Cohort Studies
Retrospective Studies
Confidence Intervals
National Health Programs
Taiwan
Proportional Hazards Models
Crohn Disease
Comorbidity
Coronary Artery Disease
Databases
Hypertension
Inflammation
Incidence
Research
Population

Keywords

  • cohort study
  • inflammatory bowel disease
  • Parkinson's disease

ASJC Scopus subject areas

  • Gastroenterology
  • Immunology and Allergy

Cite this

Association between Parkinson's disease and inflammatory bowel disease : A nationwide Taiwanese retrospective cohort study. / Lin, Jung Chun; Lin, Chin Sheng; Hsu, Chin Wang; Lin, Cheng Li; Kao, Chia Hung.

In: Inflammatory Bowel Diseases, Vol. 22, No. 5, 01.05.2016, p. 1049-1055.

Research output: Contribution to journalArticle

Lin, Jung Chun ; Lin, Chin Sheng ; Hsu, Chin Wang ; Lin, Cheng Li ; Kao, Chia Hung. / Association between Parkinson's disease and inflammatory bowel disease : A nationwide Taiwanese retrospective cohort study. In: Inflammatory Bowel Diseases. 2016 ; Vol. 22, No. 5. pp. 1049-1055.
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abstract = "Objectives: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that chronic systemic inflammation increases the risk of Parkinson's disease (PD). This study examined the effects of IBD on the development of PD. Methods: In a nationwide population-based cohort of 23.22 million insured residents of Taiwan aged ≥ 20 years, we compared people diagnosed with IBD during 2000 to 2011 (n 8373) with IBD-free individuals. Patients with PD were identified in the National Health Insurance Research Database. Using univariable and multivariable Cox proportion hazard regression models, we estimated the adjusted hazard ratio (aHR) for PD with a 95{\%} confidence interval (CI) with adjustment for age, sex, and comorbidities. Results: In the cohort, IBD was associated with an increased incidence of PD (crude hazard ratio 1.43, 95{\%} CI 1.15-1.79). The risk was highest among individuals with Crohn's disease (aHR 1.40, 95{\%} CI 1.11-1.77). In the multivariable model, the risk of PD was increased for men (aHR 1.28, 95{\%} CI 1.05-1.56) and higher for patients with hypertension (aHR 1.72, 95{\%} CI 1.33-2.24), coronary artery disease (aHR 1.31, 95{\%} CI 1.04-1.66), or depression (aHR 2.51, 95{\%} CI 1.82-3.46). Conclusions: We suggest that IBD is associated with an increased risk of PD. Patients with IBD should be aware of the potential risk for PD development.",
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