Abstract

This population-based analysis explored the association between osteoporosis and a previous diagnosis of psoriasis. We found that the adjusted odds ratio (OR) of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % confidence interval [CI], 1.42-1.94) when compared to controls. Introduction: Although previous studies have investigated this association between psoriasis and osteoporosis, significant controversy remains regarding its presence. Therefore, this study set out to explore the association between osteoporosis and a previous diagnosis of psoriasis through a population-based case-control study in Taiwan. Methods: We identified 17,507 cases with a diagnosis of osteoporosis and randomly extracted 52,521 controls without a history of osteoporosis. We used conditional logistic regression analyses to calculate the OR for having been previously diagnosed with psoriasis. Results: Subjects with osteoporosis had a significantly higher prevalence of previously diagnosed psoriasis (1.50 % vs. 0.87 %, p <0.001) compared to controls. Conditional logistic regression analysis revealed that the OR of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % CI, 1.42-1.94) when compared to controls after adjusting for monthly income, hypertension, diabetes, coronary heart disease, hyperlipidemia, rheumatoid arthritis, stroke, renal disease, Parkinson's disease, hyperthyroidism, chronic hepatopathy, Cushing's syndrome, malabsorption, tobacco use disorder, obesity, alcohol abuse/alcohol dependence syndrome, the use of SSRIs, and the use of systemic glucocorticoids. Furthermore, osteoporosis was significantly associated with a previous diagnosis of psoriasis in both sexes; the adjusted OR of prior psoriasis for cases when compared to controls was 1.52 (95 % CI, 1.16-1.99) and 1.73 (95 % CI, 1.44-2.13) for males and females, respectively. We also found that the adjusted OR of prior severe psoriasis for cases was 1.96 (95 % CI, 1.37-2.81) that of controls. Conclusions: This investigation succeeded in detecting an association between osteoporosis and prior psoriasis among both men and women.

Original languageEnglish
Pages (from-to)1835-1841
Number of pages7
JournalOsteoporosis International
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Health Insurance
Taiwan
Psoriasis
Osteoporosis
Databases
Odds Ratio
Confidence Intervals
Alcoholism
Logistic Models
Regression Analysis
Tobacco Use Disorder
Cushing Syndrome
Hyperthyroidism
Hyperlipidemias
Glucocorticoids
Population
Coronary Disease
Parkinson Disease
Case-Control Studies
Rheumatoid Arthritis

Keywords

  • Osteoporosis
  • Psoriasis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Association between osteoporosis and psoriasis : Results from the Longitudinal Health Insurance Database in Taiwan. / Keller, J. J.; Kang, J. H.; Lin, H. C.

In: Osteoporosis International, Vol. 24, No. 6, 06.2013, p. 1835-1841.

Research output: Contribution to journalArticle

@article{71a1aa79baf849df80ad08cb993ccfd6,
title = "Association between osteoporosis and psoriasis: Results from the Longitudinal Health Insurance Database in Taiwan",
abstract = "This population-based analysis explored the association between osteoporosis and a previous diagnosis of psoriasis. We found that the adjusted odds ratio (OR) of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 {\%} confidence interval [CI], 1.42-1.94) when compared to controls. Introduction: Although previous studies have investigated this association between psoriasis and osteoporosis, significant controversy remains regarding its presence. Therefore, this study set out to explore the association between osteoporosis and a previous diagnosis of psoriasis through a population-based case-control study in Taiwan. Methods: We identified 17,507 cases with a diagnosis of osteoporosis and randomly extracted 52,521 controls without a history of osteoporosis. We used conditional logistic regression analyses to calculate the OR for having been previously diagnosed with psoriasis. Results: Subjects with osteoporosis had a significantly higher prevalence of previously diagnosed psoriasis (1.50 {\%} vs. 0.87 {\%}, p <0.001) compared to controls. Conditional logistic regression analysis revealed that the OR of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 {\%} CI, 1.42-1.94) when compared to controls after adjusting for monthly income, hypertension, diabetes, coronary heart disease, hyperlipidemia, rheumatoid arthritis, stroke, renal disease, Parkinson's disease, hyperthyroidism, chronic hepatopathy, Cushing's syndrome, malabsorption, tobacco use disorder, obesity, alcohol abuse/alcohol dependence syndrome, the use of SSRIs, and the use of systemic glucocorticoids. Furthermore, osteoporosis was significantly associated with a previous diagnosis of psoriasis in both sexes; the adjusted OR of prior psoriasis for cases when compared to controls was 1.52 (95 {\%} CI, 1.16-1.99) and 1.73 (95 {\%} CI, 1.44-2.13) for males and females, respectively. We also found that the adjusted OR of prior severe psoriasis for cases was 1.96 (95 {\%} CI, 1.37-2.81) that of controls. Conclusions: This investigation succeeded in detecting an association between osteoporosis and prior psoriasis among both men and women.",
keywords = "Osteoporosis, Psoriasis",
author = "Keller, {J. J.} and Kang, {J. H.} and Lin, {H. C.}",
year = "2013",
month = "6",
doi = "10.1007/s00198-012-2185-5",
language = "English",
volume = "24",
pages = "1835--1841",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "6",

}

TY - JOUR

T1 - Association between osteoporosis and psoriasis

T2 - Results from the Longitudinal Health Insurance Database in Taiwan

AU - Keller, J. J.

AU - Kang, J. H.

AU - Lin, H. C.

PY - 2013/6

Y1 - 2013/6

N2 - This population-based analysis explored the association between osteoporosis and a previous diagnosis of psoriasis. We found that the adjusted odds ratio (OR) of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % confidence interval [CI], 1.42-1.94) when compared to controls. Introduction: Although previous studies have investigated this association between psoriasis and osteoporosis, significant controversy remains regarding its presence. Therefore, this study set out to explore the association between osteoporosis and a previous diagnosis of psoriasis through a population-based case-control study in Taiwan. Methods: We identified 17,507 cases with a diagnosis of osteoporosis and randomly extracted 52,521 controls without a history of osteoporosis. We used conditional logistic regression analyses to calculate the OR for having been previously diagnosed with psoriasis. Results: Subjects with osteoporosis had a significantly higher prevalence of previously diagnosed psoriasis (1.50 % vs. 0.87 %, p <0.001) compared to controls. Conditional logistic regression analysis revealed that the OR of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % CI, 1.42-1.94) when compared to controls after adjusting for monthly income, hypertension, diabetes, coronary heart disease, hyperlipidemia, rheumatoid arthritis, stroke, renal disease, Parkinson's disease, hyperthyroidism, chronic hepatopathy, Cushing's syndrome, malabsorption, tobacco use disorder, obesity, alcohol abuse/alcohol dependence syndrome, the use of SSRIs, and the use of systemic glucocorticoids. Furthermore, osteoporosis was significantly associated with a previous diagnosis of psoriasis in both sexes; the adjusted OR of prior psoriasis for cases when compared to controls was 1.52 (95 % CI, 1.16-1.99) and 1.73 (95 % CI, 1.44-2.13) for males and females, respectively. We also found that the adjusted OR of prior severe psoriasis for cases was 1.96 (95 % CI, 1.37-2.81) that of controls. Conclusions: This investigation succeeded in detecting an association between osteoporosis and prior psoriasis among both men and women.

AB - This population-based analysis explored the association between osteoporosis and a previous diagnosis of psoriasis. We found that the adjusted odds ratio (OR) of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % confidence interval [CI], 1.42-1.94) when compared to controls. Introduction: Although previous studies have investigated this association between psoriasis and osteoporosis, significant controversy remains regarding its presence. Therefore, this study set out to explore the association between osteoporosis and a previous diagnosis of psoriasis through a population-based case-control study in Taiwan. Methods: We identified 17,507 cases with a diagnosis of osteoporosis and randomly extracted 52,521 controls without a history of osteoporosis. We used conditional logistic regression analyses to calculate the OR for having been previously diagnosed with psoriasis. Results: Subjects with osteoporosis had a significantly higher prevalence of previously diagnosed psoriasis (1.50 % vs. 0.87 %, p <0.001) compared to controls. Conditional logistic regression analysis revealed that the OR of having been previously diagnosed with psoriasis for subjects with osteoporosis was 1.65 (95 % CI, 1.42-1.94) when compared to controls after adjusting for monthly income, hypertension, diabetes, coronary heart disease, hyperlipidemia, rheumatoid arthritis, stroke, renal disease, Parkinson's disease, hyperthyroidism, chronic hepatopathy, Cushing's syndrome, malabsorption, tobacco use disorder, obesity, alcohol abuse/alcohol dependence syndrome, the use of SSRIs, and the use of systemic glucocorticoids. Furthermore, osteoporosis was significantly associated with a previous diagnosis of psoriasis in both sexes; the adjusted OR of prior psoriasis for cases when compared to controls was 1.52 (95 % CI, 1.16-1.99) and 1.73 (95 % CI, 1.44-2.13) for males and females, respectively. We also found that the adjusted OR of prior severe psoriasis for cases was 1.96 (95 % CI, 1.37-2.81) that of controls. Conclusions: This investigation succeeded in detecting an association between osteoporosis and prior psoriasis among both men and women.

KW - Osteoporosis

KW - Psoriasis

UR - http://www.scopus.com/inward/record.url?scp=84878813908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878813908&partnerID=8YFLogxK

U2 - 10.1007/s00198-012-2185-5

DO - 10.1007/s00198-012-2185-5

M3 - Article

C2 - 23052942

AN - SCOPUS:84878813908

VL - 24

SP - 1835

EP - 1841

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 6

ER -