Association between neovascular age-related macular degeneration and dementia: A population-based case-control study in Taiwan

Shiu Dong Chung, Cha Ze Lee, Li Ting Kao, Herng Ching Lin, Ming Chieh Tsai, Jau Jiuan Sheu

Research output: Contribution to journalArticle

6 Citations (Scopus)


Most available studies focusing on the association between neovascular age-related macular degeneration (AMD) and dementia have conflicting results. This study aimed to investigate the association between previously diagnosed AMD and dementia using a populationbased dataset in Taiwan. Methods Data for this case-control study were retrospectively collected from the Taiwan National Health Insurance Research Database. We identified 13,402 subjects who had a diagnosis of dementia as cases, and 40,206 subjects without dementia as controls. A conditional logistic regression was used to examine the association of dementia with previously diagnosed neovascular AMD. Results We found that of the study sample of 53,608 subjects, 1.01% had previously diagnosed neovascular AMD, 1.35%and 0.90% for cases and the controls, respectively (p

Original languageEnglish
Article numbere0120003
JournalPLoS One
Issue number3
Publication statusPublished - Mar 6 2015


ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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